KEGG   DISEASE: Gastroesophageal reflux disease
Entry
H01602                      Disease                                

Name
Gastroesophageal reflux disease
  Subgroup
Non-erosive reflux disease (NERD)
Erosive reflux disease (ERD)
Description
Gastro-oesophageal reflux disease (GERD) is a condition in which reflux of the stomach contents into the oesophagus results in symptoms or, occasionally, complications. GERD can be classified as non-erosive reflux disease (NERD) or erosive reflux disease (ERD) based on the presence or absence of esophageal mucosal damage seen on endoscopy. ERD can manifest in a wide range of symptoms which can be subdivided into typical, atypical, and extraesophageal symptoms. Typical symptoms include heartburn and acid regurgitation which have high specificity but low sensitivity for GERD. Atypical symptoms such as epigastric pain, dyspepsia, nausea, bloating, and belching may be suggestive of GERD but may overlap with other conditions in the differential diagnosis. Lastly, there are various extraesophageal symptoms including chronic cough, asthma, laryngitis, and dental erosions. In a small but important minority, complications of peptic oesophagitis may occur including oesophageal strictures, Barrett's oesophagus, and rarely oesophageal adenocarcinoma. Hiatus hernia is statistically associated with GERD, the presence of which is relevant to surgical treatment. The diagnosis is typically made by a combination of clinical symptoms, response to acid suppression, as well as objective testing with upper endoscopy and esophageal pH monitoring. GERD is a chronic disease that typically requires long term management in the form of lifestyle modification, medical therapy and, for a subset of patients, surgical therapy. The mainstay of treatment is acid suppression which can be achieved with several classes of medications including antacids, histamine-receptor antagonists (H2RAs), or proton-pump inhibitors (PPIs).
Category
Digestive system disease
Brite
Human diseases [BR:br08402]
 Digestive system diseases
  Gastrointestinal diseases
   H01602  Gastroesophageal reflux disease
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases of oesophagus
   DA22  Gastro-oesophageal reflux disease
    H01602  Gastroesophageal reflux disease
Drug
Cimetidine [DR:D00295]
Cimetidine hydrochloride [DR:D03503]
Ranitidine hydrochloride [DR:D00673]
Famotidine [DR:D00318]
Nizatidine [DR:D00440]
Omeprazole [DR:D00455]
Omeprazole magnesium [DR:D05259]
Pantoprazole sodium [DR:D02593]
Lansoprazole [DR:D00355]
Rabeprazole sodium [DR:D00724]
Esomeprazole magnesium [DR:D01984]
Esomeprazole sodium [DR:D04056]
Esomeprazole strontium [DR:D10120]
Esomeprazole magnesium dihydrate [DR:D11114]
Dexlansoprazole [DR:D08903]
Metoclopramide hydrochloride [DR:D05008]
Omeprazole and sodium bicarbonate [DR:D11706]
Other DBs
ICD-11: DA22
ICD-10: K21
MeSH: D005764
Reference
  Authors
Patrick L
  Title
Gastroesophageal reflux disease (GERD): a review of conventional and alternative treatments.
  Journal
Altern Med Rev 16:116-33 (2011)
Reference
PMID:25133039 (description, drug)
  Authors
Badillo R, Francis D
  Title
Diagnosis and treatment of gastroesophageal reflux disease.
  Journal
World J Gastrointest Pharmacol Ther 5:105-12 (2014)
DOI:10.4292/wjgpt.v5.i3.105
Reference
  Authors
Keung C, Hebbard G
  Title
The management of gastro-oesophageal reflux disease.
  Journal
Aust Prescr 39:6-10 (2016)
DOI:10.18773/austprescr.2016.003
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