KEGG   DISEASE: Peptic ulcer
Entry
H01634                      Disease                                

Name
Peptic ulcer
Description
Peptic ulcer is a common disorder of gastrointestinal system characterized by mucosal damage secondary to pepsin and gastric acid secretion. It usually occurs in the stomach and proximal duodenum. Typical symptoms include episodic burning epigastric pain, loss of appetite, and weight loss. Pain usually occurs two to five hours after meals or on an empty stomach. The most common causes of peptic ulcer are Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Smoking increases the risk of ulcer recurrence and slows healing. Most patients are treated successfully with eradication of H. pylori and/or avoidance of NSAIDs, along with the appropriate use of antisecretory therapy. About 25 percent of patients with peptic ulcer have a serious complication such as hemorrhage, perforation, or gastric outlet obstruction. Administration of proton pump inhibitors (PPIs) and endoscopic therapy control most bleeds.
Category
Digestive system disease
Brite
Human diseases [BR:br08402]
 Digestive system diseases
  Gastrointestinal diseases
   H01634  Peptic ulcer
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases of the stomach or the duodenum
   Ulcer of stomach or duodenum
    DA60  Gastric ulcer
     H01634  Peptic ulcer
    DA61  Peptic ulcer, site unspecified
     H01634  Peptic ulcer
    DA62  Anastomotic ulcer
     H01634  Peptic ulcer
    DA63  Duodenal ulcer
     H01634  Peptic ulcer
Env factor
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Smoking
Pathogen
Drug
Cimetidine [DR:D00295]
Cimetidine hydrochloride [DR:D03503]
Ranitidine hydrochloride [DR:D00673]
Famotidine [DR:D00318]
Nizatidine [DR:D00440]
Misoprostol [DR:D00419]
Omeprazole [DR:D00455]
Omeprazole magnesium [DR:D05259]
Lansoprazole [DR:D00355]
Rabeprazole sodium [DR:D00724]
Esomeprazole magnesium [DR:D01984]
Esomeprazole sodium [DR:D04056]
Esomeprazole strontium [DR:D10120]
Esomeprazole magnesium dihydrate [DR:D11114]
Sucralfate [DR:D00446]
Glycopyrrolate [DR:D00540]
Propantheline bromide [DR:D00481]
Hyoscyamine sulfate [DR:D00719]
Chlordiazepoxide hydrochloride and clidinium bromide [DR:D10247]
Ibuprofen and famotidine [DR:D11575]
Naproxen and esomeprazole magnesium [DR:D11576]
Methscopolamine bromide [DR:D00715]
Omeprazole and sodium bicarbonate [DR:D11706]
Comment
See also H00320 Helicobacter pylori infection.
Other DBs
ICD-11: DA60 DA61 DA62 DA63
ICD-10: K25 K26 K27 K28
MeSH: D010437
Reference
  Authors
Ramakrishnan K, Salinas RC
  Title
Peptic ulcer disease.
  Journal
Am Fam Physician 76:1005-12 (2007)
Reference
  Authors
Fashner J, Gitu AC
  Title
Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection.
  Journal
Am Fam Physician 91:236-42 (2015)
Reference
PMID:2892567 (drug)
  Authors
Weir DG
  Title
Peptic ulceration.
  Journal
Br Med J (Clin Res Ed) 296:195-200 (1988)
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