| Entry |
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| Name |
Major depressive disorder |
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| Description |
Major depressive disorder (MDD) is the most common psychiatric disorder mainly characterized by depressed mood, loss of interest, feelings of worthlessness, and a high risk of suicide. Accumulated evidence suggests that both environmental and genetic factors are involved in the etiology of MDD although the pathogenesis of MDD remains unknown. Mutations in genes involved in brain serotonin synthesis, have been identified in patients. Brain serotonin deficiency has been hypothesized to play a role in a wide range of psychiatric diseases, including MDD. Several efficacious treatments for MDD are available, including different forms of psychotherapy and antidepressant medication. Recently, selective reuptake inhibitors (SSRIs, SNRIs,) have become the first-line antidepressant drug treatment of depression and replaced tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOI) due to fewer side-effects and ease of use.
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| Category |
Mental and behavioural disorder
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| Brite |
Human diseases [BR:br08402]
Other diseases
Mental and behavioural disorders
H01646 Major depressive disorder
Human diseases in ICD-11 classification [BR:br08403]
06 Mental, behavioural or neurodevelopmental disorders
Mood disorders
Depressive disorders
6A70 Single episode depressive disorder
H01646 Major depressive disorder
6A71 Recurrent depressive disorder
H01646 Major depressive disorder
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| Gene |
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| Drug |
Selegiline [DR: D03731]
Aripiprazole [DR: D01164]
Brexpiprazole [DR: D10309]
Desipramine hydrochloride [DR: D00812]
Imipramine hydrochloride [DR: D00815]
Imipramine pamoate [DR: D08071]
Trimipramine maleate [DR: D02408]
Amitriptyline hydrochloride [DR: D00809]
Nortriptyline hydrochloride [DR: D00816]
Protriptyline hydrochloride [DR: D00484]
Amoxapine [DR: D00228]
Maprotiline hydrochloride [DR: D00818]
Fluoxetine hydrochloride [DR: D00823]
Citalopram hydrobromide [DR: D00822]
Paroxetine hydrochloride hemihydrate [DR: D02260]
Paroxetine hydrochloride [DR: D05374]
Paroxetine mesylate [DR: D05375]
Sertraline hydrochloride [DR: D00825]
Escitalopram oxalate [DR: D02567]
Isocarboxazid [DR: D02580]
Tranylcypromine sulfate [DR: D00826]
Trazodone hydrochloride [DR: D00820]
Nefazodone hydrochloride [DR: D00819]
Mirtazapine [DR: D00563]
Bupropion hydrochloride [DR: D00817]
Bupropion hydrobromide [DR: D07938]
Venlafaxine hydrochloride [DR: D00821]
Duloxetine hydrochloride [DR: D01179]
Desvenlafaxine [DR: D07793]
Desvenlafaxine succinate [DR: D02570]
Desvenlafaxine succinate anhydrous [DR: D11619]
Vilazodone hydrochloride [DR: D09699]
Vortioxetine hydrobromide [DR: D10185]
Perphenazine and amitriptyline hydrochloride [DR: D10294]
Olanzapine and fluoxetine hydrochloride [DR: D10206]
Levomilnacipran hydrochloride [DR: D10133]
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| Other DBs |
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| Reference |
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| Authors |
Hou Z, Song X, Jiang W, Yue Y, Yin Y, Zhang Y, Liu Y, Yuan Y |
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| Title |
Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder. |
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| Journal |
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| Reference |
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| Authors |
Sachs BD, Rodriguiz RM, Tran HL, Iyer A, Wetsel WC, Caron MG |
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| Title |
Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. |
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| Journal |
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| Reference |
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| Authors |
Lin CX, Hu Z, Yan ZM, Li W, Chen YS, Zhao JH, Zhang LQ, Zhao B, Zhong WT, Feng D |
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| Title |
Association between HTR2A T102C polymorphism and major depressive disorder: a meta-analysis in the Chinese population. |
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| Journal |
Int J Clin Exp Med 8:20897-903 (2015) |
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| Reference |
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| Authors |
Szczepankiewicz A, Leszczynska-Rodziewicz A, Pawlak J, Narozna B, Rajewska-Rager A, Wilkosc M, Zaremba D, Maciukiewicz M, Twarowska-Hauser J |
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| Title |
FKBP5 polymorphism is associated with major depression but not with bipolar disorder. |
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| Journal |
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| Reference |
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| Authors |
Zhang Y, Becker T, Ma Y, Koesters M |
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| Title |
A systematic review of Chinese randomized clinical trials of SSRI treatment of depression. |
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| Journal |
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| Reference |
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| Authors |
Cuijpers P, Sijbrandij M, Koole SL, Andersson G, Beekman AT, Reynolds CF 3rd |
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| Title |
The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons. |
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| Journal |
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| Reference |
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| Authors |
Bruno A, Morabito P, Spina E, Muscatello MR |
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| Title |
The Role of Levomilnacipran in the Management of Major Depressive Disorder: A Comprehensive Review. |
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| Journal |
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| LinkDB |
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