Entry |
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Name |
Schizophrenia |
Description |
Schizophrenia is a common serious psychotic illness that typically emerges in late adolescence and early adulthood. It is characterized by hallucinations and delusions (commonly known as positive symptoms), social withdrawal, alogia, and flat affect (negative symptoms), and cognitive disabilities. While treatments exist for the psychotic symptoms of schizophrenia, there is no effective therapy to prevent the cognitive impairments. The disorder is substantially heritable, but expression of the clinical phenotype is likely to involve the interplay of multiple susceptibility variants, epigenetic factors, and environmental influences. Although it has been suggested that many of the promising candidate genes are involved in the development and maintenance of synaptic function, the most of them remains to be identified. The pathogenic mechanisms underlying schizophrenia are unknown, but observers have repeatedly noted pathological features involving excessive loss of gray matter and reduced numbers of synaptic structures on neurons. Recently, it has been found that alleles of the C4 genes are associated with schizophrenia in proportion to their tendency to promote greater expression of C4A in the brain.
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Category |
Mental and behavioural disorder
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Brite |
Human diseases [BR:br08402]
Other diseases
Mental and behavioural disorders
H01649 Schizophrenia
Human diseases in ICD-11 classification [BR:br08403]
06 Mental, behavioural or neurodevelopmental disorders
Schizophrenia or other primary psychotic disorders
6A20 Schizophrenia
H01649 Schizophrenia
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Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
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Gene |
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Drug |
Chlorpromazine hydrochloride [DR: D00789]
Fluphenazine decanoate [DR: D00793]
Perphenazine [DR: D00503]
Prochlorperazine maleate [DR: D00479]
Trifluoperazine hydrochloride [DR: D00799]
Thioridazine hydrochloride [DR: D00798]
Haloperidol decanoate [DR: D01898]
Haloperidol lactate [DR: D08035]
Molindone hydrochloride [DR: D00796]
Ziprasidone hydrochloride [DR: D01939]
Ziprasidone mesylate [DR: D02100]
Lurasidone hydrochloride [DR: D04820]
Thiothixene [DR: D00374]
Loxapine [DR: D02340]
Loxapine succinate [DR: D00794]
Clozapine [DR: D00283]
Olanzapine [DR: D00454]
Olanzapine pamoate [DR: D06623]
Quetiapine fumarate [DR: D00458]
Asenapine [DR: D11769]
Asenapine maleate [DR: D02995]
Risperidone [DR: D00426]
Aripiprazole [DR: D01164]
Aripiprazole lauroxil [DR: D10364]
Aripiprazole hydrate [DR: D10516]
Paliperidone [DR: D05339]
Paliperidone palmitate [DR: D05340]
Cariprazine hydrochloride [DR: D09876]
Brexpiprazole [DR: D10309]
Lumateperone tosylate [DR: D11170]
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Other DBs |
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Reference |
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Authors |
Austin J |
Title |
Schizophrenia: an update and review. |
Journal |
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Reference |
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Authors |
Cacabelos R, Martinez-Bouza R |
Title |
Genomics and pharmacogenomics of schizophrenia. |
Journal |
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Reference |
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Authors |
Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, Daly MJ, Carroll MC, Stevens B, McCarroll SA |
Title |
Schizophrenia risk from complex variation of complement component 4. |
Journal |
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Reference |
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Authors |
Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RL, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S |
Title |
Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. |
Journal |
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Reference |
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Authors |
Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ |
Title |
Disruption of two novel genes by a translocation co-segregating with schizophrenia. |
Journal |
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Reference |
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Authors |
Sinibaldi L, De Luca A, Bellacchio E, Conti E, Pasini A, Paloscia C, Spalletta G, Caltagirone C, Pizzuti A, Dallapiccola B |
Title |
Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. |
Journal |
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Reference |
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Authors |
Li T, Ma X, Sham PC, Sun X, Hu X, Wang Q, Meng H, Deng W, Liu X, Murray RM, Collier DA |
Title |
Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population. |
Journal |
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Reference |
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Authors |
Thiselton DL, Webb BT, Neale BM, Ribble RC, O'Neill FA, Walsh D, Riley BP, Kendler KS |
Title |
No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). |
Journal |
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LinkDB |
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