KEGG   DISEASE: Seborrheic dermatitis
Entry
H01652                      Disease                                

Name
Seborrheic dermatitis
Description
Seborrheic dermatitis (SD) is a common inflammatory dermatological disorder. The characteristic symptoms include scaling, erythema, and itching, which occur most often on the scalp, face, chest, back, axilla, and groin. Its incidence peaks during three age periods: in the first three months of life, during puberty, and in adulthood with an apex at 40 to 60 years of age. The cause of SD is unknown and the disease seems to be multifactorial. Malassezia yeasts are considered to play an important role. They cause an inflammatory reaction that seems to be mediated by free fatty acids, released from sebaceous triglycerides by fungal enzymes such as lipases. The lipid layer of Malassezia can also modulate pro-inflammatory cytokine production by keratinocytes. Although it can be associated with human immunodeficiency virus infection and neurologic disease (e.g., cerebrovascular event, Parkinson disease), SD typically occurs in healthy persons. Its prevalence is 1% to 3% in the general population and 34% to 83% in immunocompromised persons. Topical antifungal agents are the first-line therapy for acute and long-term treatment of SD of the face and body. Treatment includes over-the-counter shampoos and topical antifungals, calcineurin inhibitors, and corticosteroids.
Category
Skin and connective tissue disease
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H01652  Seborrheic dermatitis
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Inflammatory dermatoses
   Dermatitis and eczema
    EA81  Seborrhoeic dermatitis and related conditions
     H01652  Seborrheic dermatitis
Pathogen
Malassezia globosa [GN:mgl]
Malassezia restricta [GN:mrt]
Drug
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone butyrate [DR:D01619]
Prednisolone [DR:D00472]
Ketoconazole [DR:D00351]
Ciclopirox [DR:D03488]
Methylprednisolone [DR:D00407]
Cortisone acetate [DR:D00973]
Other DBs
ICD-11: EA81
ICD-10: L21
MeSH: D012628
Reference
  Authors
Borda LJ, Wikramanayake TC
  Title
Seborrheic Dermatitis and Dandruff: A Comprehensive Review.
  Journal
J Clin Investig Dermatol 3 (2015)
DOI:10.13188/2373-1044.1000019
Reference
  Authors
Naldi L, Diphoorn J
  Title
Seborrhoeic dermatitis of the scalp.
  Journal
BMJ Clin Evid 2015:1713 (2015)
Reference
  Authors
Clark GW, Pope SM, Jaboori KA
  Title
Diagnosis and treatment of seborrheic dermatitis.
  Journal
Am Fam Physician 91:185-90 (2015)
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