KEGG   DISEASE: Erythema multiforme
Entry
H01695                      Disease                                

Name
Erythema multiforme
Description
Erythema multiforme (EM) is an immune-mediated, mucocutaneous condition characterized by "target" lesions. Classically, EM has been separated into 2 subgroups, EM minor and EM major. In EM minor, lesions often present as papules, which might enlarge and eventually form the typical target lesion with erythema surrounding an area of central clearing. The rash in EM minor preferentially affects the limbs, specifically the extensor surfaces, however, it can also be seen throughout the body, excluding mucous membranes. EM major has mucous membrane involvement. The oral mucosa is most commonly affected, initially with edema that progresses to superficial erosions. Other surfaces that might be involved include the anogenital, ocular, and nasal mucosa. Although previously thought to be on a similar continuum of EM, and histologically appearing the same, Stevens-Johnson syndrome (SJS) is increasingly being considered a separate disease process. It is currently believed that EM is a result of an immune reaction to an inciting infectious or pharmacologic antigen. The most common infectious organisms in EM are herpes simplex virus types 1 and 2, as well as Mycoplasma pneumonia. The first line of treatment for EM is removal of the inciting factor when possible. Systemic steroids have been suggested as adjuvant therapy based on their immunosuppressant effects. To date, their use has been limited to EM major, as EM minor is self-limited.
Category
Skin and connective tissue disease
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H01695  Erythema multiforme
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Inflammatory dermatoses
   Inflammatory erythemas and other reactive inflammatory dermatoses
    EB12  Erythema multiforme
     H01695  Erythema multiforme
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Corticotropin [DR:D00146]
Cortisone acetate [DR:D00973]
Comment
See also H01694 Stevens-Johnson syndrome and Toxic epidermal necrolysis, H00365 Herpes simplex infection, and H00341 Mycoplasma pneumonia.
Other DBs
ICD-11: EB12
ICD-10: L51.9
MeSH: D004892
Reference
  Authors
Chan M, Goldman RD
  Title
Erythema multiforme in children: the steroid debate.
  Journal
Can Fam Physician 59:635-6 (2013)
DOI:10.1111/j.1600-0714.2010.00912.x
Reference
PMID:26627523 (drug)
  Authors
AlFar MY, AlRousan M, Almajali Z, Batarseh E, Alsaddi R
  Title
The use of corticosteroids in management of Herpes associated Erythema Multiforme.
  Journal
J Pak Med Assoc 65:1351-3 (2015)
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