KEGG   DISEASE: Attention deficit hyperactivity disorder (ADHD)
Entry
H01895                      Disease                                

Name
Attention deficit hyperactivity disorder (ADHD)
Description
Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder first diagnosed in childhood and frequently persistent throughout adult life. The disorder is classically characterized by symptoms of inattention, impulsivity, and hyperactivity. Many children with ADHD go on to have problems related to education, social functioning, and/or other mental illness as adolescents and young adults. Although heritability estimates are consistently high, ADHD is a genetically complex disorder characterized by multifactorial inheritance involving numerous genes of moderate effect. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD. And interaction between the dopamine and serotonin systems has been implicated in both the pathophysiology of ADHD and the mechanism of action of widely used stimulant compounds.
Category
Mental and behavioural disorder
Brite
Human diseases [BR:br08402]
 Other diseases
  Mental and behavioural disorders
   H01895  Attention deficit hyperactivity disorder (ADHD)
Human diseases in ICD-11 classification [BR:br08403]
 06 Mental, behavioural or neurodevelopmental disorders
  Neurodevelopmental disorders
   6A05  Attention deficit hyperactivity disorder
    H01895  Attention deficit hyperactivity disorder (ADHD)
Pathway
hsa04728  Dopaminergic synapse
hsa04726  Serotonergic synapse
hsa04080 Neuroactive ligand-receptor interaction   
Gene
DRD4 [HSA:1815] [KO:K04147]
DRD5 [HSA:1816] [KO:K05840]
TPH2 [HSA:121278] [KO:K00502]
Drug
Guanfacine hydrochloride [DR:D00606]
Amfetamine [DR:D07445]
Amphetamine sulfate [DR:D02074]
Dextroamphetamine sulfate [DR:D02078]
Methamphetamine hydrochloride [DR:D02242]
Methylphenidate [DR:D04999]
Methylphenidate hydrochloride [DR:D01296]
Atomoxetine hydrochloride [DR:D02574]
Dexmethylphenidate hydrochloride [DR:D03721]
Lisdexamfetamine dimesylate [DR:D04747]
Amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate and dextroamphetamine sulfate [DR:D11624]
Other DBs
ICD-11: 6A05
ICD-10: F90.0
MeSH: D001289
OMIM: 143465 613003
Reference
  Authors
Matthews M, Nigg JT, Fair DA
  Title
Attention deficit hyperactivity disorder.
  Journal
Curr Top Behav Neurosci 16:235-66 (2014)
DOI:10.1007/7854_2013_249
Reference
  Authors
Kustanovich V, Ishii J, Crawford L, Yang M, McGough JJ, McCracken JT, Smalley SL, Nelson SF
  Title
Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5.
  Journal
Mol Psychiatry 9:711-7 (2004)
DOI:10.1038/sj.mp.4001466
Reference
  Authors
Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Smidt J, Linder M, Flierl L, Knolker U, Friedel S, Schafer H, Gross C, Hebebrand J, Warnke A, Lesch KP
  Title
Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.
  Journal
Mol Psychiatry 10:1126-32 (2005)
DOI:10.1038/sj.mp.4001734
Reference
  Authors
Roskell NS, Setyawan J, Zimovetz EA, Hodgkins P
  Title
Systematic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine.
  Journal
Curr Med Res Opin 30:1673-85 (2014)
DOI:10.1185/03007995.2014.904772
Reference
PMID:26170637 (drug)
  Authors
Bello NT
  Title
Clinical utility of guanfacine extended release in the treatment of ADHD in children and adolescents.
  Journal
Patient Prefer Adherence 9:877-85 (2015)
DOI:10.2147/PPA.S73167
LinkDB

» Japanese version

DBGET integrated database retrieval system