KEGG   DISEASE: Head and neck cancer
Entry
H02420                      Disease                                

Name
Head and neck cancer
  Subgroup
Oral cancer [DS:H00016]
Salivary gland cancer [DS:H01508]
Oropharyngeal cancer [DS:H01559]
Laryngeal cancer [DS:H00055]
Tonsillar cancer [DS:H01509]
  Supergrp
Solid tumor [DS:H02421]
Description
Head and neck cancers are a heterogeneous collection of malignancies of the upper aerodigestive tract, salivary glands and thyroid. The most common type of cancer in the head and neck is squamous cell carcinoma. It mainly originates from the mucosal space, which extends from the skull base to the proximal esophagus. The head and neck region is subdivided in the oral cavity, pharynx and larynx. The pharyngeal space contains the nasopharynx, oropharynx and hypopharynx and includes the tonsils, the floor of the mouth and the soft palate. Although head and neck squamous cell carcinoma (HNSCC) is traditionally associated with smoking and alcohol drinking, a growing proportion of head and neck tumors, mainly of the oropharynx, are associated with human papilloma virus (HPV).
Category
Cancer
Brite
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of lip, oral cavity or pharynx
     2B68  Malignant neoplasms of submandibular or sublingual glands
      H02420  Head and neck cancer
     2B69  Malignant neoplasms of tonsil
      H02420  Head and neck cancer
     2B6A  Malignant neoplasms of oropharynx
      H02420  Head and neck cancer
     2B6E  Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx
      H02420  Head and neck cancer
    Malignant neoplasms of middle ear, respiratory or intrathoracic organs
     2C23  Malignant neoplasms of larynx
      H02420  Head and neck cancer
Drug
Methotrexate sodium [DR:D02115]
Docetaxel [DR:D07866]
Docetaxel [DR:D02165]
Cetuximab [DR:D03455]
Nivolumab [DR:D10316]
Pembrolizumab [DR:D10574] (PD-L1 expressed)
Hydroxyurea [DR:D00341]
Other DBs
ICD-11: 2B6E.Z 2B68.Z 2B6A.Z 2B69.0 2C23
ICD-10: C76.0
MeSH: D000077195
Reference
  Authors
Sadick M, Schoenberg SO, Hoermann K, Sadick H
  Title
Current oncologic concepts and emerging techniques for imaging of head and neck squamous cell cancer.
  Journal
GMS Curr Top Otorhinolaryngol Head Neck Surg 11:Doc08 (2012)
DOI:10.3205/cto000090
Reference
  Authors
Economopoulou P, de Bree R, Kotsantis I, Psyrri A
  Title
Diagnostic Tumor Markers in Head and Neck Squamous Cell Carcinoma (HNSCC) in the Clinical Setting.
  Journal
Front Oncol 9:827 (2019)
DOI:10.3389/fonc.2019.00827
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