KEGG   DISEASE: Soft tissue sarcomas
Entry
H02427                      Disease                                

Name
Soft tissue sarcomas;
Soft-tissue sarcomas
  Subgroup
Fibrosarcoma
Rhabdomyosarcoma [DS:H00037]
Leiomyosarcoma
Well-differentiated liposarcoma
Myxoid liposarcoma [DS:H00049]
Round-cell liposarcoma
Pleomorphic liposarcoma
Hemangiosarcoma
Epithelioid hemangiosarcoma
Kaposi sarcoma [DS:H00041]
Neurofibrosarcoma
Malignant peripheral nerve sheath tumor
Synovial sarcoma [DS:H00050]
Extraskeletal osteosarcoma
Extraskeletal myxoid chondrosarcoma [DS:H00053]
Ewing sarcoma [DS:H00035]
Alveolar soft part sarcoma [DS:H00051]
Epithelioid sarcoma
Clear cell sarcoma of soft tissue [DS:H00052]
Angiosarcoma [DS:H01666]
Undifferentiated high-grade pleomorphic sarcoma
Description
Soft-tissue sarcomas (STS) are a rare and heterogeneous group of tumors with mesenchymal origin, including muscle, endothelium, cartilage. Several common STSs have recognized translocations, which represent clinical targets. In addition to translocations, other genomic changes and epigenetic mechanisms have been shown to be involved in the histogenesis of STS as well as other cancers.
Category
Cancer
Brite
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant mesenchymal neoplasms
     2B55  Rhabdomyosarcoma, primary site
      H02427  Soft tissue sarcomas
     2B5A  Synovial sarcoma, primary site
      H02427  Soft tissue sarcomas
Drug
Trabectedin [DR:D06199]
Doxorubicin hydrochloride [DR:D01275]
Olaratumab [DR:D09939]
Pazopanib hydrochloride [DR:D05380]
Eribulin mesylate [DR:D08914]
Tazemetostat hydrobromide [DR:D11485]
Other DBs
ICD-11: 2B55 2B5A
ICD-10: C22.3 C46.1
MeSH: D012509
Reference
  Authors
Vodanovich DA, M Choong PF
  Title
Soft-tissue Sarcomas.
  Journal
Indian J Orthop 52:35-44 (2018)
DOI:10.4103/ortho.IJOrtho_220_17
Reference
  Authors
Soini Y
  Title
Epigenetic and genetic changes in soft tissue sarcomas: a review.
  Journal
APMIS 124:925-934 (2016)
DOI:10.1111/apm.12600
Reference
  Authors
Moley JF, Eberlein TJ
  Title
Soft-tissue sarcomas.
  Journal
Surg Clin North Am 80:687-708 (2000)
DOI:10.1016/s0039-6109(05)70207-3
Reference
  Authors
Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H
  Title
Soft tissue sarcomas: From a morphological to a molecular biological approach.
  Journal
Pathol Int 67:435-446 (2017)
DOI:10.1111/pin.12565
Reference
  Authors
Ratan R, Patel SR
  Title
Chemotherapy for soft tissue sarcoma.
  Journal
Cancer 122:2952-60 (2016)
DOI:10.1002/cncr.30191
Reference
  Authors
Meyer M, Seetharam M
  Title
First-Line Therapy for Metastatic Soft Tissue Sarcoma.
  Journal
Curr Treat Options Oncol 20:6 (2019)
DOI:10.1007/s11864-019-0606-9
Reference
  Authors
Walczak BE, Irwin RB
  Title
Sarcoma chemotherapy.
  Journal
J Am Acad Orthop Surg 21:480-91 (2013)
DOI:10.5435/JAAOS-21-08-480
Reference
  Authors
Wustrack R, Cooper K, Weber K
  Title
Molecular Markers in Bone and Soft-Tissue Tumors.
  Journal
JBJS Rev 4:01874474-201608000-00005 (2016)
DOI:10.2106/JBJS.RVW.15.00092
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