KEGG   DISEASE: 前立腺癌
エントリ  
H00024                                                             

名称    
前立腺癌
概要    
Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  男性生殖器のがん
   H00024  前立腺癌
ICD-11 による疾患分類 [BR:jp08403]
 02 Neoplasms
  Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of male genital organs
     2C82  Malignant neoplasms of prostate
      H00024  前立腺癌
パスウェイ 
hsa05215  前立腺癌
関連パスウェイ
hsa05202  Transcriptional misregulation in cancer
hsa05206  MicroRNAs in cancer
ネットワーク
nt06272  Prostate cancer
  エレメント
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00082  Loss of NKX3-1 to PI3K signaling pathway
N00084  Amplified AR to androgen receptor signaling pathway
N00085  Mutation-activated AR to androgen receptor signaling pathway
N00093  Loss of CDKN1B to p27-cell cycle G1/S
N00128  TMPRSS2-ERG fusion to transcriptional activation
N00129  TMPRSS2-ERG fusion to transcriptional repression
N00130  TMPRSS2-ETV5 fusion to transcriptional activation
病因遺伝子 
AR (amplification, mutation) [HSA:367] [KO:K08557]
CDKN1B (allelic loss) [HSA:1027] [KO:K06624]
NKX3.1 (allelic loss) (decreased expression) [HSA:4824] [KO:K09348]
PTEN (allelic loss) [HSA:5728] [KO:K01110]
GSTP1 (hypermethylation) [HSA:2950] [KO:K23790]
TMPRSS2-ERG (translocation) [HSA:2078] [KO:K09435]
TMPRSS2-ETV1 (translocation) [HSA:2115] [KO:K09431]
TMPRSS2-ETV4 (translocation) [HSA:2118] [KO:K15592]
TMPRSS2-ETV5 (translocation) [HSA:2119] [KO:K15593]
SLC45A3-ETV1 (translocation) [HSA:2115] [KO:K09431]
SLC45A3-ELK4 (translocation) [HSA:2005] [KO:K04376]
DDX5-ETV4 (translocation) [HSA:2118] [KO:K15592]
発癌物質  
Cadmium and cadmium compounds [CPD:C01413]
Chimney sweeping
治療薬   
デキサメタゾン [DR:D00292]
デキサメタゾンリン酸エステルナトリウム [DR:D00975]
ベタメタゾンリン酸エステルナトリウム [DR:D00972]
トリアムシノロンアセトニド [DR:D00983]
ヒドロコルチゾンコハク酸エステルナトリウム [DR:D00978]
トリアムシノロン [DR:D00385]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
プレドニゾロンコハク酸エステルナトリウム [DR:D01239]
メチルプレドニゾロン [DR:D00407]
メチルプレドニゾロン酢酸エステル [DR:D00979]
エチニルエストラジオール [DR:D00554]
クロルマジノン酢酸エステル [DR:D01299]
リュープロレリン酢酸塩 [DR:D00989]
ゴセレリン酢酸塩 [DR:D00573]
デガレリクス酢酸塩 [DR:D09400]
イホスファミド [DR:D00343]
エストラムスチンリン酸エステルナトリウム水和物 [DR:D06397]
テガフール・ウラシル [DR:D02131]
ペプロマイシン硫酸塩 [DR:D02063]
ドセタキセル水和物 [DR:D02165]
ドセタキセル [DR:D07866]
カバジタキセルアセトン付加物 [DR:D10452]
シスプラチン [DR:D00275]
オラパリブ [DR:D09730] (BRCA遺伝子変異陽性)
フルタミド [DR:D00586]
ビカルタミド [DR:D00961]
エンザルタミド [DR:D10218]
アパルタミド [DR:D11040]
ダロルタミド [DR:D11045]
アビラテロン酢酸エステル [DR:D09701]
塩化ラジウム [DR:D10398]
コメント  
ICD-O: 8140/3, Tumor type: Adenocarcinoma (acinar)
ICD-O: 8148/2, Tumor type: Prostatic intraepithelial neoplasia, glade III (PIN III)
リンク   
ICD-11: 2C82
ICD-10: C61
文献    
PMID:12878745 (gene, tumor type)
  著者
Nelson WG, De Marzo AM, Isaacs WB.
  タイトル
Prostate cancer.
  雑誌
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
文献    
PMID:17384581 (gene, tumor type)
  著者
De Marzo AM, Platz EA, Sutcliffe S, Xu J, Gronberg H, Drake CG, Nakai Y, Isaacs WB, Nelson WG.
  タイトル
Inflammation in prostate carcinogenesis.
  雑誌
Nat Rev Cancer 7:256-69 (2007)
DOI:10.1038/nrc2090
文献    
PMID:11018010 (tumor type)
  著者
Abate-Shen C, Shen MM.
  タイトル
Molecular genetics of prostate cancer.
  雑誌
Genes Dev 14:2410-34 (2000)
DOI:10.1101/gad.819500
文献    
  著者
Porkka KP, Visakorpi T.
  タイトル
Molecular mechanisms of prostate cancer.
  雑誌
Eur Urol 45:683-91 (2004)
DOI:10.1016/j.eururo.2004.01.012
文献    
  著者
Brenner JC, Chinnaiyan AM
  タイトル
Translocations in epithelial cancers.
  雑誌
Biochim Biophys Acta 1796:201-15 (2009)
DOI:10.1016/j.bbcan.2009.04.005
文献    
PMID:15660110 (carcinogen)
  著者
Luch A.
  タイトル
Nature and nurture - lessons from chemical carcinogenesis.
  雑誌
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
文献    
PMID:9498904 (carcinogen)
  著者
Boffetta P, Jourenkova N, Gustavsson P.
  タイトル
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.
  雑誌
Cancer Causes Control 8:444-72 (1997)
DOI:10.1023/a:1018465507029
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