KEGG   DISEASE: 外陰癌
エントリ  
H00029                                                             

名称    
外陰癌
概要    
Vulvar cancer is a relatively uncommon malignancy, occurring at a rate of 2.2 per 100,000 women per year. Squamous cell carcinoma (SCC) is the most common type of vulvar cancer and is observed in 80% to 90% of cases. There are at least two quite different types of SCC of the vulva. The less common, accounting for about one-third of cases, occurs in relatively young women, is usually preceded by the undifferentiated form of vulvar squamous intraepithelial neoplasia (VIN) and is associated with high-risk human papillomavirus (HPV) infection; the more frequent form develops in elderly patients, is not commonly associated with undifferentiated VIN but is frequently associated with differentiated VIN, lichen sclerosus or squamous hyperplasia, and is generally not linked to HPV infection. Relatively little is known about molecular changes in the genesis of vulvar cancer. Some studies suggest that early p53 mutation may be a defining step only in HPV-negative tumors. A rather small study suggests that mutation in phosphatase and tensin homologue (PTEN) is an early change in a substantial subset of vulvar carcinomas.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  乳房および女性生殖器のがん
   H00029  外陰癌
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍, 原発性と確定または推定されるもの, 明示された部位のもの, ただしリンパ, 造血, 中枢神経系, 関連組織を除く
    女性生殖器の悪性腫瘍
     2C70  外陰の悪性腫瘍
      H00029  外陰癌
関連パスウェイ
hsa05200  Pathways in cancer
hsa05165  Human papillomavirus infection
病因遺伝子 
PTEN (mutation) [HSA:5728] [KO:K01110]
p53 (mutation) [HSA:7157] [KO:K04451]
発癌物質  
Azathioprine [CPD:C06837]
Tobacco smoking and tobacco smoke
病原体   
Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]
治療薬   
組換え沈降4価ヒトパピローマウイルス様粒子ワクチン [DR:D10192]
コメント  
ICD-O: 8070/3, Tumor type: Squamous cell carcinoma
リンク   
ICD-11: 2C70
ICD-10: C51
MeSH: D014846
文献    
PMID:12605639 (description, gene, carcinogen, tumor type)
  著者
Fox H, Wells M
  タイトル
Recent advances in the pathology of the vulva.
  雑誌
Histopathology 42:209-16 (2003)
DOI:10.1046/j.1365-2559.2003.01578.x
文献    
PMID:19286150 (description, carcinogen)
  著者
Lanneau GS, Argenta PA, Lanneau MS, Riffenburgh RH, Gold MA, McMeekin DS, Webster N, Judson PL
  タイトル
Vulvar cancer in young women: demographic features and outcome evaluation.
  雑誌
Am J Obstet Gynecol 200:645.e1-5 (2009)
DOI:10.1016/j.ajog.2009.01.014
文献    
PMID:10955808 (gene, tumor type)
  著者
Holway AH, Rieger-Christ KM, Miner WR, Cain JW, Dugan JM, Pezza JA, Silverman ML, Shapter A, McLellan R, Summerhayes IC.
  タイトル
Somatic mutation of PTEN in vulvar cancer.
  雑誌
Clin Cancer Res 6:3228-35 (2000)
文献    
PMID:11156383 (gene, tumor type)
  著者
Brooks LA, Tidy JA, Gusterson B, Hiller L, O'Nions J, Gasco M, Marin MC, Farrell PJ, Kaelin WG Jr, Crook T.
  タイトル
Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus.
  雑誌
Cancer Res 60:6875-7 (2000)
文献    
PMID:15203746 (marker, tumor type)
  著者
Marjoniemi VM.
  タイトル
Immunohistochemistry in gynaecological pathology: a review.
  雑誌
Pathology 36:109-19 (2004)
DOI:10.1080/00313020410001671948
文献    
PMID:11281434 (carcinogen)
  著者
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.
  タイトル
Human papillomavirus infections: epidemiology, pathogenesis, and therapy.
  雑誌
J Cutan Med Surg 5:43-60 (2001)
DOI:10.1177/120347540100500110
文献    
PMID:1311142 (carcinogen)
  著者
Daling JR, Sherman KJ, Hislop TG, Maden C, Mandelson MT, Beckmann AM, Weiss NS.
  タイトル
Cigarette smoking and the risk of anogenital cancer.
  雑誌
Am J Epidemiol 135:180-9 (1992)
DOI:10.1093/oxfordjournals.aje.a116270
文献    
PMID:16062089 (carcinogen)
  著者
Patel P, Moazzam N, Potti A, Mehdi SA.
  タイトル
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  雑誌
Am J Clin Oncol 28:427-8 (2005)
DOI:10.1097/01.coc.0000168670.28659.8d
文献    
PMID:12605088 (marker)
  著者
Nucci MR, Castrillon DH, Bai H, Quade BJ, Ince TA, Genest DR, Lee KR, Mutter GL, Crum CP.
  タイトル
Biomarkers in diagnostic obstetric and gynecologic pathology: a review.
  雑誌
Adv Anat Pathol 10:55-68 (2003)
DOI:10.1097/00125480-200303000-00001
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