心房細動

心房細動は最もよくみられる不整脈であり、一般的には弧発性、後天性の疾患であるとみなされているが、近年、カリウムチャネル遺伝子等の異常による遺伝性の家族性心房細動の研究が進められている。

心疾患

(ATFB3) KCNQ1 [HSA:3784] [KO:K04926]
(ATFB4) KCNE2 [HSA:9992] [KO:K04896]
(ATFB6) NPPA [HSA:4878] [KO:K12334]
(ATFB7) KCNA5 [HSA:3741] [KO:K04878]
(ATFB9) KCNJ2 [HSA:3759] [KO:K04996]
(ATFB10) SCN5A [HSA:6331] [KO:K04838]
(ATFB11) GJA5 [HSA:2702] [KO:K07614]
(ATFB12) ABCC9 [HSA:10060] [KO:K05033]
(ATFB13) SCN1B [HSA:6324] [KO:K04845]
(ATFB14) SCN2B [HSA:6327] [KO:K04846]
(ATFB15) NUP155 [HSA:9631] [KO:K14312]
(ATFB16) SCN3B [HSA:55800] [KO:K04847]
(ATFB17) SCN4B [HSA:6330] [KO:K04848]
(ATFB18) MYL4 [HSA:4635] [KO:K12750]

プロカインアミド塩酸塩 [DR:D00477]
キニジン硫酸塩水和物 [DR:D02272]
プロプラノロール塩酸塩 [DR:D00483]
アセブトロール塩酸塩 [DR:D00597]
ビソプロロールフマル酸塩 [DR:D00634]
ランジオロール塩酸塩 [DR:D01847]
ジソピラミド [DR:D00303]
フレカイニド酢酸塩 [DR:D00638]
アミオダロン塩酸塩 [DR:D00636]
ベラパミル塩酸塩 [DR:D00619]
ベプリジル塩酸塩水和物 [DR:D00631]
ビソプロロール [DR:D02342]
カルベジロール [DR:D00255]

PMID:18634977

Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT

Molecular genetics of atrial fibrillation.

J Am Coll Cardiol 52:241-50 (2008)
DOI:10.1016/j.jacc.2008.02.072

PMID:17768091

Otway R, Vandenberg JI, Fatkin D

Atrial fibrillation--a new cardiac channelopathy.

Heart Lung Circ 16:356-60 (2007)
DOI:10.1016/j.hlc.2007.07.003

PMID:19808477

Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM

Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.

Circ Arrhythm Electrophysiol 2:268-75 (2009)
DOI:10.1161/CIRCEP.108.779181

PMID:19070573

Zhang X, Chen S, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, Wang QK

Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death.

Cell 135:1017-27 (2008)
DOI:10.1016/j.cell.2008.10.022

PMID:21051419

Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH

Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation.

Cardiovasc Res 89:786-93 (2011)
DOI:10.1093/cvr/cvq348

PMID:27066836

Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH

A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.

Nat Commun 7:11303 (2016)
DOI:10.1038/ncomms11303