KEGG   DISEASE: 心房細動
エントリ  
H00731                                                             
名称    
心房細動
概要    
Atrial fibrillation (AF, ATFB) is the most common cardiac arrhythmia and is regarded generally as a sporadic, acquired disorder. Nevertheless, recent growing evidence points to an important heritable basis for AF. By linkage analysis, several loci have been mapped for monogenetic AF. Some of these loci encode for subunits of potassium channels.
カテゴリ  
心疾患
階層分類  
ヒト疾患 [BR:jp08402]
 循環器系疾患
  心疾患
   H00731  心房細動
ICD-11 による疾患分類 [BR:jp08403]
 11 循環器系の疾患
  不整脈
   上室性調律異常
    BC81  上室頻脈性不整脈
     H00731  心房細動
関連パスウェイ
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04921  Oxytocin signaling pathway
hsa04725  Cholinergic synapse
hsa04924  Renin secretion
病因遺伝子 
(ATFB3) KCNQ1 [HSA:3784] [KO:K04926]
(ATFB4) KCNE2 [HSA:9992] [KO:K04896]
(ATFB6) NPPA [HSA:4878] [KO:K12334]
(ATFB7) KCNA5 [HSA:3741] [KO:K04878]
(ATFB9) KCNJ2 [HSA:3759] [KO:K04996]
(ATFB10) SCN5A [HSA:6331] [KO:K04838]
(ATFB11) GJA5 [HSA:2702] [KO:K07614]
(ATFB12) ABCC9 [HSA:10060] [KO:K05033]
(ATFB13) SCN1B [HSA:6324] [KO:K04845]
(ATFB14) SCN2B [HSA:6327] [KO:K04846]
(ATFB15) NUP155 [HSA:9631] [KO:K14312]
(ATFB16) SCN3B [HSA:55800] [KO:K04847]
(ATFB17) SCN4B [HSA:6330] [KO:K04848]
(ATFB18) MYL4 [HSA:4635] [KO:K12750]
治療薬   
プロカインアミド塩酸塩 [DR:D00477]
キニジン硫酸塩水和物 [DR:D02272]
プロプラノロール塩酸塩 [DR:D00483]
アセブトロール塩酸塩 [DR:D00597]
ビソプロロールフマル酸塩 [DR:D00634]
ランジオロール塩酸塩 [DR:D01847]
ジソピラミド [DR:D00303]
フレカイニド酢酸塩 [DR:D00638]
アミオダロン塩酸塩 [DR:D00636]
ベラパミル塩酸塩 [DR:D00619]
ベプリジル塩酸塩水和物 [DR:D00631]
ビソプロロール [DR:D02342]
カルベジロール [DR:D00255]
リンク   
ICD-11: BC81.3
ICD-10: I48
OMIM: 608583 607554 611493 612201 612240 613980 614022 614049 614050 615377 615378 615770 613120 611819 617280
文献    
PMID:18634977
  著者
Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT
  タイトル
Molecular genetics of atrial fibrillation.
  雑誌
J Am Coll Cardiol 52:241-50 (2008)
DOI:10.1016/j.jacc.2008.02.072
文献    
PMID:17768091
  著者
Otway R, Vandenberg JI, Fatkin D
  タイトル
Atrial fibrillation--a new cardiac channelopathy.
  雑誌
Heart Lung Circ 16:356-60 (2007)
DOI:10.1016/j.hlc.2007.07.003
文献    
PMID:19808477
  著者
Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM
  タイトル
Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.
  雑誌
Circ Arrhythm Electrophysiol 2:268-75 (2009)
DOI:10.1161/CIRCEP.108.779181
文献    
PMID:19070573
  著者
Zhang X, Chen S, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, Wang QK
  タイトル
Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death.
  雑誌
Cell 135:1017-27 (2008)
DOI:10.1016/j.cell.2008.10.022
文献    
PMID:21051419
  著者
Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH
  タイトル
Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation.
  雑誌
Cardiovasc Res 89:786-93 (2011)
DOI:10.1093/cvr/cvq348
文献    
PMID:27066836
  著者
Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH
  タイトル
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
  雑誌
Nat Commun 7:11303 (2016)
DOI:10.1038/ncomms11303
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