KEGG   DISEASE: 二次性副甲状腺機能亢進症
エントリ  
H01669                                                             

名称    
二次性副甲状腺機能亢進症;
続発性副甲状腺機能亢進症
概要    
Secondary hyperparathyroidism (SHPT) is a chronic and progressive disorder characterized by elevated serum parathyroid hormone (PTH), parathyroid gland hyperplasia, and disturbances in mineral metabolism, mainly calcium and phosphorus. SHPT is generally caused by diffuse parathyroid hyperplasia in response to prolonged reduced levels of extracellular calcium from various secondary aetiologies. Although it is initially and adaptive response to a variety of stimuli resulting mainly in extracellular hypocalcaemia (vitamin D deficiency, chronic kidney disease, idiopathic hypercalciuria, calcium malabsorption), long-standing SHPT may eventually develop into autonomous HPT (ie, tertiary HPT). Because SHPT is a compensatory mechanism of the parathyroid glands, it commonly resolves with normalization of calcium and phosphorus homeostasis. After excluding reversible secondary aetiologies, first-line treatment of irreversible SHPT (often related to chronic kidney disease) mainly involves medical therapies.
カテゴリ  
内分泌系疾患
階層分類  
ヒト疾患 [BR:jp08402]
 内分泌代謝疾患
  副甲状腺疾患
   H01669  二次性副甲状腺機能亢進症
ICD-11 による疾患分類 [BR:jp08403]
 05 Endocrine, nutritional or metabolic diseases
  Endocrine diseases
   Disorders of the parathyroids or parathyroid hormone system
    5A51  Hyperparathyroidism
     H01669  二次性副甲状腺機能亢進症
治療薬   
マキサカルシトール [DR:D01098]
カルシトリオール [DR:D00129]
ファレカルシトリオール [DR:D01662]
シナカルセト塩酸塩 [DR:D03505]
エテルカルセチド塩酸塩 [DR:D10677]
エボカルセト [DR:D11063]
リンク   
ICD-11: 5A51.1
ICD-10: E21.1
MeSH: D006962
文献    
  著者
Cozzolino M, Tomlinson J, Walsh L, Bellasi A
  タイトル
Emerging drugs for secondary hyperparathyroidism.
  雑誌
Expert Opin Emerg Drugs 20:197-208 (2015)
DOI:10.1517/14728214.2015.1018177
文献    
  著者
Duan K, Gomez Hernandez K, Mete O
  タイトル
Clinicopathological correlates of hyperparathyroidism.
  雑誌
J Clin Pathol 68:771-87 (2015)
DOI:10.1136/jclinpath-2015-203186
文献    
PMID:27479950 (description, drug)
  著者
Yuen NK, Ananthakrishnan S, Campbell MJ
  タイトル
Hyperparathyroidism of Renal Disease.
  雑誌
Perm J 20:78-83 (2016)
DOI:10.7812/TPP/15-127
文献    
PMID:28277829 (drug)
  著者
Hamano N, Komaba H, Fukagawa M
  タイトル
Etelcalcetide for the treatment of secondary hyperparathyroidism.
  雑誌
Expert Opin Pharmacother 18:529-534 (2017)
DOI:10.1080/14656566.2017.1303482
文献    
PMID:9708607 (drug)
  著者
Akiba T, Marumo F, Owada A, Kurihara S, Inoue A, Chida Y, Ando R, Shinoda T, Ishida Y, Ohashi Y
  タイトル
Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.
  雑誌
Am J Kidney Dis 32:238-46 (1998)
DOI:10.1053/ajkd.1998.v32.pm9708607
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