KEGG   DISEASE: 乳児発症性 STING 関連血管炎
エントリ  
H01746                                                             

名称    
乳児発症性 STING 関連血管炎
概要    
STING (stimulator of interferon genes)-associated basculopathy with onset in infancy (SAVI) is a rare hereditary autoinflammatory disorder caused by gain-of-function mutations in TMEM173, the gene encoding the STING protein. It is considered that the mutations in the TMEM173 gene confer constitutive activation of STING and hypersensitivity to ligand stimulation, resulting in chronic activation of the STING-interferon pathway. Patients with SAVI have severe neonatal-onset small vessel vasculitis, which is expressed by telangiectatic ulcerative rashes in the limbs, earlobes, or nose, leading to microangiopathic thrombosis, vessel occlusion, and even risk of gangrene. Some SAVI patients may present chronic interstitial lung disease, which can be severe and lethal.
カテゴリ  
免疫系疾患
階層分類  
ヒト疾患 [BR:jp08402]
 免疫系疾患
  その他の免疫系疾患
   H01746  乳児発症性 STING 関連血管炎
パスウェイ 
hsa04621  NOD 様レセプターシグナル伝達経路
hsa04622  RIG-I 様レセプターシグナル伝達経路
hsa04623  細胞内 DNA センサーパスウェイ
病因遺伝子 
TMEM173 [HSA:340061] [KO:K12654]
リンク   
ICD-10: M35.8
OMIM: 615934
文献    
  著者
Tarantino G, Esposito S, Andreozzi L, Bracci B, D'Errico F, Rigante D
  タイトル
Lung Involvement in Children with Hereditary Autoinflammatory Disorders.
  雑誌
Int J Mol Sci 17:E2111 (2016)
DOI:10.3390/ijms17122111
文献    
  著者
Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CC, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R
  タイトル
Activated STING in a vascular and pulmonary syndrome.
  雑誌
N Engl J Med 371:507-18 (2014)
DOI:10.1056/NEJMoa1312625
文献    
  著者
Jeremiah N, Neven B, Gentili M, Callebaut I, Maschalidi S, Stolzenberg MC, Goudin N, Fremond ML, Nitschke P, Molina TJ, Blanche S, Picard C, Rice GI, Crow YJ, Manel N, Fischer A, Bader-Meunier B, Rieux-Laucat F
  タイトル
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations.
  雑誌
J Clin Invest 124:5516-20 (2014)
DOI:10.1172/JCI79100
LinkDB    

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