KEGG   ENZYME: 1.1.1.146
Entry
EC 1.1.1.146                Enzyme                                 

Name
11beta-hydroxysteroid dehydrogenase;
corticosteroid 11beta-dehydrogenase;
beta-hydroxysteroid dehydrogenase;
11beta-hydroxy steroid dehydrogenase;
corticosteroid 11-reductase;
dehydrogenase, 11beta-hydroxy steroid
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
11beta-hydroxysteroid:NADP+ 11-oxidoreductase
Reaction(IUBMB)
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ [RN:R03203]
Reaction(KEGG)
R03203 > R02836 R03848 R04758 R04840;
(other) R09420
Substrate
11beta-hydroxysteroid [CPD:C01058];
NADP+ [CPD:C00006]
Product
11-oxosteroid [CPD:C01985];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.146 created 1972
Pathway
ec00140  Steroid hormone biosynthesis
ec00980  Metabolism of xenobiotics by cytochrome P450
ec01100  Metabolic pathways
Orthology
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1
K22418  11beta/17beta-hydroxysteroid dehydrogenase
Genes
HSA: 3290(HSD11B1) 374875(HSD11B1L)
PTR: 455621(HSD11B1L) 457698(HSD11B1)
PPS: 100978384(HSD11B1L) 100981291(HSD11B1)
GGO: 101147766(HSD11B1)
PON: 100453076(HSD11B1) 100460111(HSD11B1L)
NLE: 100585349(HSD11B1L) 100593811(HSD11B1)
MCC: 574322(HSD11B1) 696612(HSD11B1L)
MCF: 101867467(HSD11B1) 102133758(HSD11B1L)
CSAB: 103230154(HSD11B1) 103233739(HSD11B1L)
RRO: 104664165(HSD11B1) 104665396(HSD11B1L)
RBB: 108512097(HSD11B1L) 108539553(HSD11B1)
CJC: 100396148(HSD11B1L) 100401212(HSD11B1)
SBQ: 101040472(HSD11B1)
MMU: 15483(Hsd11b1)
MCAL: 110305040(Hsd11b1)
MPAH: 110322100(Hsd11b1)
RNO: 25116(Hsd11b1)
MUN: 110553509(Hsd11b1)
CGE: 100762502(Hsd11b1)
NGI: 103727028(Hsd11b1) 103737207(Hsd11b1l)
HGL: 101716800(Hsd11b1)
CCAN: 109681612(Hsd11b1) 109688202(Hsd11b1l)
OCU: 100342395(HSD11B1) 103346788(HSD11B1L)
TUP: 102468477(HSD11B1L) 102502602(HSD11B1)
CFA: 449023(HSD11B1) 485027(HSD11B1L)
VVP: 112907163(HSD11B1) 112935555(HSD11B1L)
AML: 100466840(HSD11B1) 100468195(HSD11B1L)
UMR: 103672488(HSD11B1) 103681853(HSD11B1L)
UAH: 113262645(HSD11B1)
ORO: 101367811(HSD11B1L) 101369340(HSD11B1)
ELK: 111162366
FCA: 100529248(HSD11B1) 101092746(HSD11B1L)
PTG: 102967279(HSD11B1)
PPAD: 109255094(HSD11B1) 109255928(HSD11B1L)
AJU: 106975451(HSD11B1L) 106981789(HSD11B1)
BTA: 282589(HSD11B1) 404546(HSD11B1L)
BOM: 102270204(HSD11B1L) 102275244(HSD11B1)
BIU: 109561722(HSD11B1L) 109570467(HSD11B1)
BBUB: 102409054(HSD11B1) 102409560(HSD11B1L)
CHX: 102168375(HSD11B1) 102182297(HSD11B1L)
OAS: 101109443(HSD11B1L) 443409(HSD11B1)
SSC: 100512268(HSD11B1L) 397480(HSD11B1)
CFR: 102503994(HSD11B1)
CDK: 105091757(HSD11B1L) 105099329(HSD11B1)
BACU: 103004239(HSD11B1)
LVE: 103076014(HSD11B1L) 103086619(HSD11B1)
OOR: 101274286(HSD11B1L) 101284098(HSD11B1)
DLE: 111165962(HSD11B1L) 111184723(HSD11B1)
PCAD: 102979045(HSD11B1L) 102992666(HSD11B1)
ECB: 100056429(HSD11B1)
EPZ: 103548673(HSD11B1)
EAI: 106827175(HSD11B1) 106832397(HSD11B1L)
MYB: 102260050(HSD11B1)
MYD: 102755655(HSD11B1L) 102771648(HSD11B1)
MNA: 107532934(HSD11B1)
HAI: 109388583(HSD11B1L)
DRO: 112297497(HSD11B1) 112312415(HSD11B1L)
PALE: 102882377(HSD11B1) 102898543(HSD11B1L)
RAY: 107510916(HSD11B1L) 107517624(HSD11B1)
MJV: 108396749(HSD11B1) 108404622(HSD11B1L)
LAV: 100667019(HSD11B1)
SHR: 100923255(HSD11B1)
PCW: 110222669(HSD11B1)
OAA: 100079059(HSD11B1) 103165340(HSD11B1L)
GGA: 408034(HSD11B1L) 419861(HSD11B1b) 771930(HSD11B1a)
MGP: 100540872(HSD11B1L) 100550364(HSD11B1) 100550517
CJO: 107324848 107324849(HSD11B1) 107325408(HSD11B1L)
NMEL: 110388207 110388337(HSD11B1) 110388940(HSD11B1L)
APLA: 101803228(HSD11B1) 101803565(HSD11B1L) 101804020
ACYG: 106041293 106041294 106049558(HSD11B1L)
LSR: 110475377 110475385 110475766(HSD11B1L)
SCAN: 103821934(HSD11B1L) 103823273 103823329
GFR: 102037915 102038088 102042869(HSD11B1L)
FAB: 101815030 101815431 101816480(HSD11B1L)
PHI: 102101549 102103573(HSD11B1L) 102113769
PMAJ: 107214842 107214843(HSD11B1) 107215575(HSD11B1L)
CCAE: 111922428 111939805(HSD11B1) 111940332(HSD11B1L)
CCW: 104692327 104692500 104696996(HSD11B1L)
ETL: 114063124(HSD11B1) 114063139 114066353(HSD11B1L)
FPG: 101918372 101922906(HSD11B1L) 101924921
FCH: 102051959 102052853(HSD11B1L) 102053319(HSD11B1)
CLV: 102086357(HSD11B1) 102090135 102093278(HSD11B1L)
EGZ: 104124375(HSD11B1L) 104126798 104126829
NNI: 104010310 104010345 104016278(HSD11B1L)
PADL: 103923460(HSD11B1L) 103923566 103923602
AMJ: 102560317(HSD11B1L) 102568341(HSD11B1)
ACS: 100555338(hsd11b1) 100555943 100565341(hsd11b1l)
PVT: 110072366(HSD11B1) 110079276(HSD11B1L) 110081926
PBI: 103052790 103059600(HSD11B1)
PMUR: 107292272(HSD11B1) 107301624
TSR: 106539582(HSD11B1)
PMUA: 114586681 114587149 114599353(HSD11B1)
GJA: 107126071(HSD11B1) 107126084
XLA: 108709376(hsd11b1.S) 379494(hsd11b1l.2.L) 379497(hsd11b1.L) 399012(hsd11b1l.L) 733357(hsd11b1l.S)
XTR: 100037875(hsd11b1l) 100038278(hsd11b1l.2) 100489345(hsd11b1)
DRE: 100006793 100333777(hsd11b1lb) 393293(hsd11b1la)
CCAR: 109094152
IPU: 108271267(hsd11b1l)
PHYP: 113534521(hsd11b1l)
AMEX: 103039071(hsd11b1l)
EEE: 113576173(hsd11b1l)
TRU: 101065468(hsd11b1l)
LCO: 104920644(hsd11b1l)
NCC: 104940951
OLA: 100049405(hsd11b1l)
XCO: 114150802(hsd11b1l) 114150803
PRET: 103463669 103463670(hsd11b1l)
NFU: 107393308 107393309(hsd11b1l)
AOCE: 111578536(hsd11b1l)
CSEM: 103399936(hsd11b1l)
POV: 109625538(hsd11b1l)
LCF: 108877326(hsd11b1l)
SDU: 111232186(hsd11b1l)
SLAL: 111657468(hsd11b1l)
HCQ: 109532027(hsd11b1l)
MALB: 109965675
ELS: 105011540(hsd11b1l) 105020762
PKI: 111836680(hsd11b1l)
LCM: 102345616(HSD11B1) 102353052(HSD11B1L)
CMK: 103181944(hsd11b1l) 103182506(hsd11b1)
SPU: 764876
PCAN: 112558142
CRG: 105339932
OBI: 106874424
EPA: 110252440
ADF: 107340777
PDAM: 113664253
SPIS: 111336520
AQU: 100631443
ATH: AT3G47350(HSD2) AT4G10020(HSD5) AT5G50600(HSD1) AT5G50700(HSD1)
LJA: Lj4g3v2883370.1(Lj4g3v2883370.1) Lj4g3v2894400.1(Lj4g3v2894400.1)
DOSA: Os02t0511100-00(Os02g0511100) Os02t0511400-01(Os02g0511400) Os03t0842900-01(Os03g0842900) Os04t0390700-01(Os04g0390700) Os04t0390800-01(Os04g0390800) Os11t0499600-01(Os11g0499600) Os12t0464400-01(Os12g0464400)
ATS: 109743639(LOC109743639) 109747869(LOC109747869) 109752621(LOC109752621) 109752622(LOC109752622) 109764613(LOC109764613)
CNE: CNF01570
CNB: CNBF3140
ABP: AGABI1DRAFT122304(AGABI1DRAFT_122304)
ABV: AGABI2DRAFT229948(AGABI2DRAFT_229948)
POL: Bpro_3168
MXA: MXAN_0817
CCX: COCOR_00702(yqjQ)
RUL: UC8_26440
GAU: GAU_3589
DORI: FH5T_00195
PHE: Phep_3027
SLI: Slin_1686
 » show all
Reference
1  [PMID:2808402]
  Authors
Agarwal AK, Monder C, Eckstein B, White PC.
  Title
Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.
  Journal
J Biol Chem 264:18939-43 (1989)
  Sequence
[rno:25116]
Reference
2  [PMID:4384445]
  Authors
Bush IE, Hunter SA, Meigs RA.
  Title
Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver.
  Journal
Biochem J 107:239-58 (1968)
DOI:10.1042/bj1070239
Reference
3  [PMID:3139396]
  Authors
Lakshmi V, Monder C.
  Title
Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex.
  Journal
Endocrinology 123:2390-8 (1988)
DOI:10.1210/endo-123-5-2390
Reference
4  [PMID:2661206]
  Authors
Phillips DM, Lakshmi V, Monder C.
  Title
Corticosteroid 11 beta-dehydrogenase in rat testis.
  Journal
Endocrinology 125:209-16 (1989)
DOI:10.1210/endo-125-1-209
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.146
IUBMB Enzyme Nomenclature: 1.1.1.146
ExPASy - ENZYME nomenclature database: 1.1.1.146
BRENDA, the Enzyme Database: 1.1.1.146
CAS: 9041-46-7
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