Entry |
|
Name |
prostaglandin-F synthase;
prostaglandin-D2 11-reductase;
reductase, 15-hydroxy-11-oxoprostaglandin;
PGD2 11-ketoreductase;
PGF2alpha synthetase;
prostaglandin 11-ketoreductase;
prostaglandin D2-ketoreductase;
prostaglandin F synthase;
prostaglandin F synthetase;
synthetase, prostaglandin F2alpha;
PGF synthetase;
NADPH-dependent prostaglandin D2 11-keto reductase;
prostaglandin 11-keto reductase
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase
|
Reaction(IUBMB) |
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ [RN: R02684]
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Reaction(KEGG) |
|
Substrate |
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD: C00639];
NADP+ [CPD: C00006]
|
Product |
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD: C00696];
NADPH [CPD: C00005];
H+ [CPD: C00080]
|
Comment |
Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
|
History |
EC 1.1.1.188 created 1984, modified 1989, modified 1990
|
Pathway |
ec00590 | Arachidonic acid metabolism |
|
Orthology |
K04119 | aldo-keto reductase family 1 member C3 |
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Genes |
» show all
|
Reference |
|
Authors |
Reingold DF, Kawasaki A, Needleman P. |
Title |
A novel prostaglandin 11-keto reductase found in rabbit liver. |
Journal |
|
Reference |
2 |
Authors |
Watanabe, K., Shimizu, T. and Hayaishi, O. |
Title |
Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung. |
Journal |
Biochem Int 2:603-610 (1981) |
Reference |
|
Authors |
Watanabe K, Yoshida R, Shimizu T, Hayaishi O. |
Title |
Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. |
Journal |
J Biol Chem 260:7035-41 (1985) |
Reference |
|
Authors |
Wong PY. |
Title |
Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver. |
Journal |
|
Reference |
|
Authors |
Wong PY. |
Title |
Purification of PGD2 11-ketoreductase from rabbit liver. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.188 |
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LinkDB |
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