KEGG ENZYME: 1.1.1.188

ENZYME: 1.1.1.188

Entry

EC 1.1.1.188 Enzyme

Name

prostaglandin-F synthase;
prostaglandin-D2 11-reductase;
reductase, 15-hydroxy-11-oxoprostaglandin;
PGD2 11-ketoreductase;
PGF2alpha synthetase;
prostaglandin 11-ketoreductase;
prostaglandin D2-ketoreductase;
prostaglandin F synthase;
prostaglandin F synthetase;
synthetase, prostaglandin F2alpha;
PGF synthetase;
NADPH-dependent prostaglandin D2 11-keto reductase;
prostaglandin 11-keto reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase

Reaction(IUBMB)

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02684]

Reaction(KEGG)

R02684;
(other) R02799

Substrate

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]

Product

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.

History

EC 1.1.1.188 created 1984, modified 1989, modified 1990

Pathway

ec00590

Arachidonic acid metabolism

Orthology

K04119

aldo-keto reductase family 1 member C3

Genes

HSA:	8644(AKR1C3)

PTR:	100612718(AKR1C3)

PPS:	100986388(AKR1C3)

GGO:

101144878

PON:	100174617(AKR1C3)

NLE:

100604844

MCC:

711440

MCF:	102142023(HSD17B5)

RBB:

108532990

SBQ:

101041594

MUN:

110560700

CFA:	497070(AKR1C3)

FCA:	100510801(AKR1C3)

PTG:

102963188

PPAD:

109273789

AJU:

106988139

BTA:	100139386(20ALPHA-HSD) 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884 785762

BOM:

102269337

BIU:

109568087

BBUB:

102395293

SSC:	733634(AKR1C1)

BACU:

LVE:

PCAD:

ECB:

MYB:

MYD:

TMU:

OAA:

PSS:

PVT:

XLA:	100049750(LOC100490956.L) 443571(akr1c3.L)

XTR:	105946859 779627(akr1c3)

» show all

Reference

1 [PMID:7248318]

Authors

Reingold DF, Kawasaki A, Needleman P.

Title

A novel prostaglandin 11-keto reductase found in rabbit liver.

Journal

Biochim Biophys Acta 659:179-88 (1981)
DOI:10.1016/0005-2744(81)90282-5

Reference

Authors

Watanabe, K., Shimizu, T. and Hayaishi, O.

Title

Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung.

Journal

Biochem Int 2:603-610 (1981)

Reference

3 [PMID:3858278]

Authors

Watanabe K, Yoshida R, Shimizu T, Hayaishi O.

Title

Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.

Journal

J Biol Chem 260:7035-41 (1985)

Reference

4 [PMID:7248317]

Authors

Wong PY.

Title

Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.

Journal

Biochim Biophys Acta 659:169-78 (1981)
DOI:10.1016/0005-2744(81)90281-3

Reference

5 [PMID:7132748]