KEGG   ENZYME: 1.1.1.188
Entry
EC 1.1.1.188                Enzyme                                 

Name
prostaglandin-F synthase;
prostaglandin-D2 11-reductase;
reductase, 15-hydroxy-11-oxoprostaglandin;
PGD2 11-ketoreductase;
PGF2alpha synthetase;
prostaglandin 11-ketoreductase;
prostaglandin D2-ketoreductase;
prostaglandin F synthase;
prostaglandin F synthetase;
synthetase, prostaglandin F2alpha;
PGF synthetase;
NADPH-dependent prostaglandin D2 11-keto reductase;
prostaglandin 11-keto reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02684]
Reaction(KEGG)
R02684;
(other) R02799
Substrate
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]
Product
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
History
EC 1.1.1.188 created 1984, modified 1989, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K04119  aldo-keto reductase family 1 member C3
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3) 100612887 746545
PPS: 100971300 100986388(AKR1C3) 100987632 100988315
GGO: 101144878 101147265 101152195
PON: 100174617(AKR1C3) 100432652 100461633 100462259
NLE: 100593325 100604844 100606512
MCC: 100430336 722485 722496
MCF: 102116465(AKR1C2) 102143072 102144231
CSAB: 103237812 103237813 103237816
RRO: 104674747
RBB: 108521036 108532990
CJC: 100406962 100409025 100409384
SBQ: 101041594 101042225 101049957
MCAL: 110308148
MPAH: 110321514 110333839 110333848
RNO: 361267(Akr1cl)
MUN: 110560700
CGE: 100768090 100768376
NGI: 103725884 103725890 103725892 103746652
HGL: 101702106
CCAN: 109678869 109680334 109680482 109680990
TUP: 102478063 102478495 102491222 102491650
CFA: 497070(AKR1C3)
VVP: 112933725
AML: 100483758
UMR: 103676234
UAH: 113241124
ORO: 101377633 101379669
ELK: 111158636
FCA: 100510801(AKR1C3)
PTG: 102963188
PPAD: 109273789
AJU: 106988139
BTA: 100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
BOM: 102267155 102269337 102271037 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205
BIU: 109567627 109567629 109568074 109568076 109568077 109568079 109568080 109568087
BBUB: 102389138 102395293 102395635 102396460 102396772 102397840 102398476 102398800 102399119 102400645 102404780 102415550 102416534
CHX: 102176340 102176622 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498
OAS: 101106610 101107119 101107541 101107809 101109111 101109377 101109633 101110434 101110693 105614315 106990122 114108656 443108(PGFS)
SSC: 654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
CFR: 102511678 116656624 116661570
CDK: 105104488 105104489 105105880
BACU: 103002145 103003050
LVE: 103069218
OOR: 101273575 101281536
DLE: 111170128 111170129
PCAD: 102978533
ECB: 100057212 100070491 100070501 100070509 100070616 111771771 111771772
EPZ: 103541472 103541473 103542048
EAI: 106824650 106827241 106827468 106846832 106846833 106846834
MYB: 102254990 102255491
MYD: 102751586 102763642
MNA: 107542430 107542432
HAI: 109378613
DRO: 112321159 112323007
MJV: 108383288 108384939 108393830 108407235 108407237 108407238
LAV: 100659630 100659914
TMU: 101342771 101360332
OAA: 100085065 100085965 100085983
PSS: 102446010 102446253 102446483
CMY: 102946053
CPIC: 101940001 101940260 101940524
PVT: 110070400 110071420 110088827
PMUA: 114590236 114604979 114604980 114604981 114605230 114605592
GJA: 107108026
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 734139 779627(akr1c3)
NPR: 108789947 108789949 108799287 108799288 108799289 108799290 108799291
 » show all
Reference
1  [PMID:7248318]
  Authors
Reingold DF, Kawasaki A, Needleman P.
  Title
A novel prostaglandin 11-keto reductase found in rabbit liver.
  Journal
Biochim Biophys Acta 659:179-88 (1981)
DOI:10.1016/0005-2744(81)90282-5
Reference
2
  Authors
Watanabe, K., Shimizu, T. and Hayaishi, O.
  Title
Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung.
  Journal
Biochem Int 2:603-610 (1981)
Reference
3  [PMID:3858278]
  Authors
Watanabe K, Yoshida R, Shimizu T, Hayaishi O.
  Title
Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.
  Journal
J Biol Chem 260:7035-41 (1985)
Reference
4  [PMID:7248317]
  Authors
Wong PY.
  Title
Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.
  Journal
Biochim Biophys Acta 659:169-78 (1981)
DOI:10.1016/0005-2744(81)90281-3
Reference
5  [PMID:7132748]
  Authors
Wong PY.
  Title
Purification of PGD2 11-ketoreductase from rabbit liver.
  Journal
Methods Enzymol 86:117-25 (1982)
DOI:10.1016/0076-6879(82)86179-x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.188
IUBMB Enzyme Nomenclature: 1.1.1.188
ExPASy - ENZYME nomenclature database: 1.1.1.188
BRENDA, the Enzyme Database: 1.1.1.188
CAS: 55976-95-9
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