KEGG ENZYME: 1.1.1.237

ENZYME: 1.1.1.237

Entry

EC 1.1.1.237 Enzyme

Name

hydroxyphenylpyruvate reductase;
HPPR

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase

Reaction(IUBMB)

(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03337 R03339];
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03373 R12252]

Reaction(KEGG)

R03337 R03339 R03373 R12252;
(other) R01370 R01371

Substrate

(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:C22038]

Product

3-(4-hydroxyphenyl)pyruvate [CPD:C01179];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-(3,4-dihydroxyphenyl)pyruvate [CPD:C04045]

Comment

The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.

History

EC 1.1.1.237 created 1992, modified 2018

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec00350

Tyrosine metabolism

ec00360

Phenylalanine metabolism

ec00960

Tropane, piperidine and pyridine alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K18606

hydroxyphenylpyruvate reductase

Genes

GRA:

105767921

GHI:	107906523 107941083

EGR:

CSV:

CMAX:

CMOS:

CPEP:

SOT:

CANN:

NTA:	107815351 107815507

NSY:

NTO:

NAU:

INI:

SIND:

OEU:	111367158 111370835

HAN:

110894224

LSV:	111910276 111910278

DCR:

BVG:

NNU:

Reference

Authors

Petersen, M. and Alfermann, A.W.

Title

Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.

Journal

Z Naturforsch C: Biosci 43:501-504 (1988)

Reference

2 [PMID:15284489]

Authors

Kim KH, Janiak V, Petersen M

Title

Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei.

Journal

Plant Mol Biol 54:311-23 (2004)
DOI:10.1023/B:PLAN.0000036367.03056.b2

Sequence

[ag:CAD47810]

Reference

3 [PMID:25918800]

Authors

Kim YB, Uddina MR, Kim Y, Park CG, Park SU

Title

Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis.

Journal

Nat Prod Commun 9:1311-4 (2014)

Reference

4 [PMID:29329649]

Authors

Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS

Title

HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza.

Journal

Chin J Nat Med 15:917-927 (2017)
DOI:10.1016/S1875-5364(18)30008-6

Sequence

[ag:AAZ67354]