Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase

(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03337 R03339];
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03373 R12252]

R03337 R03339 R03373 R12252;
(other) R01370 R01371
Reaction

(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:C22038]

The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.

EC 1.1.1.237 created 1992, modified 2018

1

Petersen, M. and Alfermann, A.W.

Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.

Z Naturforsch C: Biosci 43:501-504 (1988)

2  [PMID:15284489]

Kim KH, Janiak V, Petersen M

Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei.

Plant Mol Biol 54:311-23 (2004)
DOI:10.1023/B:PLAN.0000036367.03056.b2

[ag:CAD47810]

3  [PMID:25918800]

Kim YB, Uddina MR, Kim Y, Park CG, Park SU

Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria  baicalensis.

Nat Prod Commun 9:1311-4 (2014)

4  [PMID:29329649]

Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS

HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza.

Chin J Nat Med 15:917-927 (2017)
DOI:10.1016/S1875-5364(18)30008-6

[ag:AAZ67354]