Entry |
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Name |
hydroxyphenylpyruvate reductase;
HPPR
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase
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Reaction(IUBMB) |
(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN: R03337 R03339];
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+ [RN: R03373 R12252]
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Reaction(KEGG) |
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Substrate |
(R)-3-(4-hydroxyphenyl)lactate [CPD: C03964];
NAD+ [CPD: C00003];
NADP+ [CPD: C00006];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD: C22038]
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Product |
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Comment |
The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
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History |
EC 1.1.1.237 created 1992, modified 2018
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Pathway |
ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
ec00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K13574 | hydroxycarboxylate dehydrogenase B |
K18606 | hydroxyphenylpyruvate reductase |
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Genes |
» show all
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Reference |
1 |
Authors |
Petersen, M. and Alfermann, A.W. |
Title |
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase. |
Journal |
Z Naturforsch C: Biosci 43:501-504 (1988) |
Reference |
|
Authors |
Kim KH, Janiak V, Petersen M |
Title |
Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei. |
Journal |
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Sequence |
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Reference |
|
Authors |
Kim YB, Uddina MR, Kim Y, Park CG, Park SU |
Title |
Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis. |
Journal |
Nat Prod Commun 9:1311-4 (2014) |
Reference |
|
Authors |
Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS |
Title |
HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.237 |
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LinkDB |
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