Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

L-quinate:NAD(P)+ 3-oxidoreductase

(1) L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+ [RN:R01872 R06846];
(2) shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+ [RN:R02413 R06847]

R01872 R02413 R06846 R06847
Reaction

L-quinate [CPD:C00296];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
shikimate [CPD:C00493]

This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, shikimate dehydrogenase, in that it can use both quinate and shikimate as substrate and either NAD+ or NADP+ as acceptor.

EC 1.1.1.282 created 2004

1  [PMID:12637497]

Michel G, Roszak AW, Sauve V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ.

Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.

J Biol Chem 278:19463-72 (2003)
DOI:10.1074/jbc.M300794200

[eco:b1692]

2  [PMID:12624088]

Benach J, Lee I, Edstrom W, Kuzin AP, Chiang Y, Acton TB, Montelione GT, Hunt JF.

The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase.

J Biol Chem 278:19176-82 (2003)
DOI:10.1074/jbc.M301348200

[eco:b1692]