KEGG   ENZYME: 1.1.1.315
Entry
EC 1.1.1.315                Enzyme                                 

Name
11-cis-retinol dehydrogenase;
RDH5 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
11-cis-retinol:NAD+ oxidoreductase
Reaction(IUBMB)
11-cis-retinol---[retinal-binding-protein] + NAD+ = 11-cis-retinal---[retinol-binding-protein] + NADH + H+
Reaction(KEGG)
(other) R03048 R08382
Substrate
11-cis-retinol---[retinal-binding-protein];
NAD+ [CPD:C00003]
Product
11-cis-retinal---[retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2].
History
EC 1.1.1.315 created 2011
Orthology
K00061  11-cis-retinol dehydrogenase
Genes
HSA: 5959(RDH5)
PTR: 467029(RDH5)
PPS: 100988391(RDH5)
GGO: 101125878(RDH5)
PON: 100437933(RDH5)
NLE: 100598708(RDH5)
MCC: 709644(RDH5)
MCF: 107126391(RDH5)
CSAB: 103238482(RDH5)
RRO: 104673711(RDH5)
RBB: 108516026(RDH5)
CJC: 100402026(RDH5)
SBQ: 101051979(RDH5)
MMU: 19682(Rdh5)
MCAL: 110303548(Rdh5)
MPAH: 110327089(Rdh5)
RNO: 366791(Rdh5)
MUN: 110563162(Rdh5)
CGE: 100772460(Rdh5)
NGI: 103738827(Rdh5)
HGL: 101701578(Rdh5)
CCAN: 109696229(Rdh5)
OCU: 100346443(RDH5)
TUP: 102492697(RDH5)
CFA: 481098(RDH5)
VVP: 112922414(RDH5)
AML: 100477613(RDH5)
UMR: 103682388(RDH5)
UAH: 113256460(RDH5)
ORO: 101378842(RDH5)
ELK: 111160231
FCA: 101090450(RDH5)
PTG: 102955802(RDH5)
PPAD: 109270294(RDH5)
AJU: 106986902(RDH5)
BTA: 281448(RDH5)
BOM: 102281461(RDH5)
BIU: 109559397(RDH5)
BBUB: 102405059(RDH5)
CHX: 102179453(RDH5)
OAS: 101115199(RDH5)
SSC: 100517586(RDH5)
CFR: 102522460(RDH5)
CDK: 105086399(RDH5)
BACU: 103013640(RDH5)
LVE: 103070515(RDH5)
OOR: 101272361(RDH5)
DLE: 111173906(RDH5)
PCAD: 102981003(RDH5)
ECB: 100051379(RDH5)
EPZ: 103560206(RDH5)
EAI: 106841311(RDH5)
MYB: 102250054(RDH5)
MYD: 102752637(RDH5)
MNA: 107538219(RDH5)
HAI: 109396898(RDH5)
DRO: 112319078(RDH5)
PALE: 102890960(RDH5)
RAY: 107521261(RDH5)
MJV: 108395935(RDH5)
LAV: 100665758(RDH5)
TMU: 101359207
SHR: 100926680(RDH5)
PCW: 110210897(RDH5)
OAA: 100077776(RDH5)
GGA: 395452(RDH5)
CJO: 107316746 107325819(RDH5)
NMEL: 110391116(RDH5)
LSR: 110483543
PHI: 102110114(RDH5)
ETL: 114070099(RDH5)
FPG: 101913547(DHRS9)
CLV: 102088293(RDH5)
ACUN: 113482107
ASN: 102385802(RDH5)
AMJ: 102572099(RDH5)
PSS: 102452664(RDH5)
CPIC: 101937595(RDH5)
ACS: 100557709 100561257(rdh5)
PVT: 110073773(RDH5) 110076901
PBI: 103065660(RDH5)
PMUR: 107294926(RDH5)
TSR: 106544310(RDH5)
PMUA: 114587482(RDH5) 114606043
GJA: 107121726(RDH5)
XLA: 444623(rdh5.L) 447549(rdh5.S)
XTR: 100124842 496830(rdh5)
NPR: 108796498(RDH5) 108796978
DRE: 556528(rdh5)
SANH: 107653177
IPU: 108281000(rdh5)
PHYP: 113538008(rdh5)
AMEX: 103030619
EEE: 113580614
TRU: 101069778
LCO: 104922032(rdh5) 104931041
NCC: 104964277
ONL: 100699208 100710882(rdh5)
OLA: 100125503(rdh5)
CVG: 107103450(rdh5)
NFU: 107385384(rdh5) 107390047
KMR: 108231532(rdh5) 108240756
ALIM: 106512921 106517650(rdh5)
AOCE: 111576058(rdh5)
CSEM: 103386710(rdh5)
POV: 109635450(rdh5)
SDU: 111233581(rdh5)
SLAL: 111653059 111655098(rdh5)
HCQ: 109521663(rdh5) 109526951
BPEC: 110173750(rdh5)
MALB: 109969798(rdh5)
LCM: 102353642(DHRS9) 102365116
CMK: 103176390 103180707(rdh5)
BMY: Bm1_16425
PDAM: 113684761
SPIS: 111327939
 » show all
Reference
1  [PMID:7836368]
  Authors
Simon A, Hellman U, Wernstedt C, Eriksson U
  Title
The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases.
  Journal
J Biol Chem 270:1107-12 (1995)
DOI:10.1074/jbc.270.3.1107
  Sequence
[bta:281448]
Reference
2  [PMID:9931293]
  Authors
Wang J, Chai X, Eriksson U, Napoli JL
  Title
Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.
  Journal
Biochem J 338 ( Pt 1):23-7 (1999)
  Sequence
[hsa:5959]
Reference
3  [PMID:11675386]
  Authors
Liden M, Romert A, Tryggvason K, Persson B, Eriksson U
  Title
Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.
  Journal
J Biol Chem 276:49251-7 (2001)
DOI:10.1074/jbc.M107337200
  Sequence
[hsa:5959]
Reference
4  [PMID:12536149]
  Authors
Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW
  Title
Mapping the ligand binding pocket in the cellular retinaldehyde binding protein.
  Journal
J Biol Chem 278:12390-6 (2003)
DOI:10.1074/jbc.M212775200
  Sequence
[hsa:5959]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.315
IUBMB Enzyme Nomenclature: 1.1.1.315
ExPASy - ENZYME nomenclature database: 1.1.1.315
BRENDA, the Enzyme Database: 1.1.1.315
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