KEGG   ENZYME: 1.1.1.338
Entry
EC 1.1.1.338                Enzyme                                 
Name
(2R)-3-sulfolactate dehydrogenase (NADP+);
(R)-sulfolactate:NADP+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R)-3-sulfolactate:NADP+ oxidoreductase
Reaction(IUBMB)
(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+ [RN:R07137]
Reaction(KEGG)
R07137
Substrate
(2R)-3-sulfolactate [CPD:C11537];
NADP+ [CPD:C00006]
Product
3-sulfopyruvate [CPD:C05528];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.
History
EC 1.1.1.338 created 2012
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K16844  (2R)-3-sulfolactate dehydrogenase (NADP+)
Genes
ASUB: NLZ15_10115
GKD: K6Q96_17400 K6Q96_22195
PAQM: E0F26_07615
SSAL: SPISAL_05330
SHAI: LMH63_10855
APRS: BI364_08720
GAI: IMCC3135_02485(dpkA)
CSA: Csal_1771
HBE: BEI_0839(comC)
HCAM: I4484_16840
HSX: HNO51_16740
LLP: GH975_02520
SVA: SVA_1861
TSN: W908_08240
THIN: CRN91_01900
RPJ: N234_02640
CUH: BJN34_26765
REU: Reut_B3531
CTI: RALTA_B0842
CBW: RR42_m0457
CGD: CR3_0184(comC)
COX: E0W60_13295
CCAX: KZ686_04920
CNAN: A2G96_27600
BGE: BC1002_3744
BFN: OI25_4405
PARA: BTO02_21280
PGIS: I6I06_21475
PACS: FAZ98_25220
PEW: KZJ38_22635
PDQ: CL55_00014430
PANI: DCO16_07890
PWU: A8O14_02440
PTX: ABW99_10900
PAND: DRB87_03425
CABA: SBC2_17590(comC)
BUO: BRPE64_DCDS09650
CABK: NK8_49320 NK8_54730
TVL: FAZ95_15400
BPAR: BN117_4156
BPA: BPP4084
BBH: BN112_3867
BBR: BB4555
BBM: BN115_4232
BBX: BBS798_4332
BPT: Bpet0408
BHO: D560_1789
BHM: D558_1780
BHZ: ACR54_04291(comC)
BBRO: BAU06_18085
BFZ: BAU07_08195
BPDZ: BBN53_01625
BOH: AKI39_17280
BGM: CAL15_02260
BGV: CAL12_19025
AXY: AXYL_00470
AXO: NH44784_017151
AXN: AX27061_0476
AXX: ERS451415_00470(allD_1)
ADT: APT56_02485
AIS: BUW96_28010
ASW: CVS48_03845
ACHR: C2U31_07135
ACHB: DVB37_02035
ADY: HLG70_19615
ACHO: H4P35_02075
AMUI: PE062_26085
APES: FOC84_10150
AAEG: RA224_02310
ASEL: RAS12_19645
AKA: TKWG_24430
AMIM: MIM_c39390
PARK: LSG25_12715
VEI: Veis_0890
VAP: Vapar_3821
VPD: VAPA_1c39340
HYN: F9K07_27970
HGR: DW355_01255
RGE: RGE_25200
ATER: MW290_05755 MW290_18650
HAR: HEAR3341
ACTB: RHM62_14990
URU: DSM104443_03883(comC)
UPL: DSM104440_03444(comC)
ACOM: CEW83_08345
BPRC: D521_1333
BEBA: BWI17_07600
MESW: A9K65_032710
NIY: FQ775_22310
MESO: BSQ44_12895
CHEA: PVE73_02260
AAK: AA2016_5548
AMIS: Amn_pa00430
PHT: BLM14_27990
KMN: HW532_06425
SME: SMa1459
SMK: Sinme_5990
SMQ: SinmeB_6310
SMX: SM11_pC0853
SMI: BN406_04533
SMEG: C770_GR4pC0580
SMEL: SM2011_a1459
SMER: DU99_22025
SMD: Smed_5101
SIX: BSY16_4749
EMX: FKV68_25165
SKM: PZL22_004997
ATU: Atu0164
ATA: AWN88_20420
AGR: AGROH133_03129(mdh)
ATF: Ach5_01490(comC)
AGC: BSY240_4080
AGT: EYD00_13065
ALF: CFBP5473_00210
ARUI: G6M88_08520
AVQ: HRR99_00325
ASAL: CFBP5507_13745
RIR: BN877_I0162(comC)
RPUS: CFBP5875_13395
ACUC: KZ699_13560
ALEG: CFBP4996_13765
RTR: RTCIAT899_CH17445
RHL: LPU83_4041
RGA: RGR602_CH03906
RHV: BA939_09550
RJG: CCGE525_20485
RHR: CKA34_00710
ROY: G3A56_10685
RLS: HB780_24490
RROS: D4A92_00210
ARA: Arad_4516
ARO: B0909_12670
NGL: RG1141_CH42250
NGG: RG540_CH42620
NEO: CYG48_15725
NEN: NCHU2750_38690(comC)
NPM: QEO92_25520
OCA: OCAR_7551
OCG: OCA5_c05890
OCO: OCA4_c05880
PCAX: AFIC_002273
VGO: GJW-30_1_00128(comC_1)
BVV: BHK69_06980 BHK69_18045
BVES: QO058_00760
BOP: AXW83_05590 AXW83_16725 AXW83_22765
BOS: BSY19_2613
BOI: BLM15_06695
BOF: FQV39_06440
BOSE: RMR04_15905
AZC: AZC_1795
ANC: GBB76_08720
APRA: G3A50_05870
APOL: K9D25_10450
MRD: Mrad2831_5976
MNO: Mnod_3707
METI: DK427_02125
MMES: MMSR116_04760
RVA: Rvan_2276
RLAC: QMO75_13565
FIL: BN1229_v1_1880(comC)
FIY: BN1229_v1_1883(comC)
RHZ: RHPLAN_09770
CMET: K6K41_04855
HDI: HDIA_2769(comC)
MEY: TM49_04085
AUZ: Sa4125_38850
AUB: LXB15_20880
JIE: OH818_06315 OH818_14910
PSF: PSE_2587
PPHR: APZ00_23875
LABR: CHH27_12015
LABP: FJ695_09900
RPOP: K1718_07225
SIW: GH266_22245
PHR: C6569_06525
PSTG: E8M01_21820
PAQT: E8L99_13580
SIL: SPO3187(comC)
SIT: TM1040_3386
RUA: D1823_14280
RUT: FIU92_16940(comC2)
RCON: K3740_15190
RUY: NOR97_15850
JAN: Jann_2141
RDE: RD1_2049
RLI: RLO149_c011950
RPON: G3256_04620
RFU: ROLI_028910(comC)
DSH: Dshi_2039
PGL: PGA2_239p1590
PGD: Gal_03878
PHP: PhaeoP97_03708
PPIC: PhaeoP14_03602
PHQ: D1820_17760
OAT: OAN307_c11640
OAR: OA238_c06130
OTM: OSB_22100(comC)
OCT: FTO60_04615
LMD: METH_04595
LEJ: ETW24_05715
LAQU: R2C4_12835
LEV: ETW23_13980
LCAE: K3721_04360
RED: roselon_00573
MALG: MALG_01235
TPRO: Ga0080559_TMP3622
SUAM: BOO69_05270
SULZ: C1J03_16430
SULI: C1J05_05125 C1J05_17400
SMED: JNX03_07670
SUAL: KDD17_03365
TOM: BWR18_04315
RMM: ROSMUCSMR3_03370(comC)
ROK: RAK1035_2264
RID: RIdsm_03387(comC)
ROM: EI983_05780
RPEL: N7U68_05250
AHT: ANTHELSMS3_02624(comC)
THAA: CFI11_16630
MALU: KU6B_15290
LALG: LentiSH36_01702
TRY: QF118_17585
MARU: FIU81_03610(comC)
FYT: QF092_19375
PSEW: JHW44_18575
PAEX: JHW48_16235
PFEO: E3U26_14695
PTP: RCA23_c28070
RSU: NHU_04237
RHM: B5V46_17735
TSCO: R1T40_21520
DON: BSK21_09390
SEDI: EBB79_05885
PPSO: QPJ95_17495
BOO: E2K80_00685
PPRU: FDP22_15055
PAED: G5B38_00025
MON: G8E03_11005
POZ: I0K15_17265
PALW: PSAL_021170(comC_1) PSAL_028040(comC_2)
PSHQ: F3W81_14630
PGV: SL003B_2798
CACT: HZ995_04875 HZ995_04905
CMAG: CBW24_05865
GCE: KYE46_09860
GYJ: AADW23_12735
ACRO: K3J57_06480
AMYL: QBD29_10025
AMAQ: GO499_07050
RHOC: QTA57_02755
RBG: BG454_07280 BG454_15345
BOSG: GKR98_15060
FAQ: G5B39_15425
RBX: I3V23_00805 I3V23_10955
RGI: RGI145_14315
ROS: CTJ15_21625
RMUC: FOB66_16340
RFL: Rmf_46700
RCV: PFY06_00200
SRF: LHU95_02160
ACIM: GT370_19980
SHUM: STHU_20860
SVC: STVA_23970
STEL: STAQ_18750
NAO: Y958_25125
NCB: C0V82_01495
RCE: RC1_0266
TXI: TH3_01035
THAC: CSC3H3_12430
TII: DY252_20595
THAI: IT893_00945
TLU: R1T41_09430
TTB: MACH01_01820
THGO: M9H61_12040
VSU: P3M64_05640
ELIO: KO353_01265 KO353_13150
NACI: NUH88_09415
THAR: T8K17_05770
APC: HIMB59_00001300
SNEA: NBZ79_15985
DVM: DvMF_1995
CLIH: KPS_002235
TMUR: JBF11_07055
DALK: DSCA_63910
DMP: FAK_06050
CGY: CGLY_02555
CFK: CFRA_01855
CEE: CENDO_00120(comC)
CSAN: E3227_04380
CRL: NCTC7448_00063(allD)
CYZ: C3B44_10085
CLIA: C3E79_10890
CGF: CGUA_08970(comC)
RHA: RHA1_ro08843
RKO: JWS14_29120 JWS14_47740
GPD: GII33_21655
SARM: DVA86_02085
SATK: SA2016_2196
BKI: M4486_12640
BHH: Bra3105_09810
CET: B8281_12080
CCEU: CBR64_19660
BLIN: BLSMQ_0125
BSPO: L1F31_00710
MPH: MLP_09960 MLP_21640
AMAZ: LUW76_22380
ACTQ: OG417_30930
PLAN: A1s21148_06275
PVN: A7sIIA15_00855
MRB: Mrub_2460
MRE: K649_10230
MTAI: Mtai_v1c20750
MSV: Mesil_1014
 » show all
Reference
1  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0
  Sequence
[csa:Csal_1771]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.338
IUBMB Enzyme Nomenclature: 1.1.1.338
ExPASy - ENZYME nomenclature database: 1.1.1.338
BRENDA, the Enzyme Database: 1.1.1.338
CAS: 81210-65-3
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