| Entry |
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| Name |
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+);
tll (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
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| Reaction(IUBMB) |
dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ [RN: R10190]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.
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| History |
EC 1.1.1.339 created 2012
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| Pathway |
| ec00523 | Polyketide sugar unit biosynthesis |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K19180 | dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) |
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| Genes |
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| Reference |
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| Authors |
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T |
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| Title |
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.339 |
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| LinkDB |
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