Entry |
|
Name |
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+);
tll (gene name)
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
|
Reaction(IUBMB) |
dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ [RN: R10190]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.
|
History |
EC 1.1.1.339 created 2012
|
Pathway |
ec00523 | Polyketide sugar unit biosynthesis |
ec00541 | O-Antigen nucleotide sugar biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K19180 | dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) |
|
Genes |
|
Reference |
|
Authors |
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T |
Title |
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. |
Journal |
|
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.339 |
|
LinkDB |
|