| Entry |
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| Name |
hydroxymethylglutaryl-CoA reductase (NADPH);
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate);
3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl CoA reductase (NADPH);
S-3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
NADPH-hydroxymethylglutaryl-CoA reductase;
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA);
3-hydroxy-3-methylglutaryl CoA reductase (NADPH);
hydroxymethylglutaryl-CoA reductase (NADPH2)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
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| Reaction(IUBMB) |
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [RN: R02082]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
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| History |
EC 1.1.1.34 created 1961
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00021 | hydroxymethylglutaryl-CoA reductase (NADPH) |
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| Genes |
» show all
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| Reference |
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| Authors |
BUCHER NL, OVERATH P, LYNEN F |
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| Title |
beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver. |
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| Journal |
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| Reference |
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| Authors |
DURR IF, RUDNEY H. |
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| Title |
The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. |
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| Journal |
J Biol Chem 235:2572-8 (1960) |
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| Reference |
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| Authors |
Kawachi T, Rudney H. |
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| Title |
Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.34 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.34 |
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| LinkDB |
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