EC 188.8.131.521 Enzyme
phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase (decarboxylating)
6-phospho-D-gluconate + NAD(P)+ = D-ribulose 5-phosphate + CO2 + NAD(P)H + H+ [RN:
D-ribulose 5-phosphate [CPD:
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC
, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC
, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating].
EC 184.108.40.2061 created 2013
Ben-Bassat A, Goldberg I
Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C.
Biochim Biophys Acta 611:1-10 (1980)
Stournaras C, Maurer P, Kurz G
6-phospho-D-gluconate dehydrogenase from Pseudomonas fluorescens. Properties and subunit structure.
Eur J Biochem 130:391-6 (1983)
Levy HR, Vought VE, Yin X, Adams MJ
Identification of an arginine residue in the dual coenzyme-specific glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides that plays a key role in binding NADP+ but not NAD+.
Arch Biochem Biophys 326:145-51 (1996)
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