KEGG   ENZYME: 1.1.1.360Help
Entry
EC 1.1.1.360                Enzyme                                 

Name
glucose/galactose 1-dehydrogenase;
GdhA;
dual-specific glucose/galactose dehydrogenase;
glucose (galactose) dehydrogenase;
glucose/galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glucose/D-galactose 1-dehydrogenase (NADPH)
Reaction(IUBMB)
(1) D-glucopyranose + NADP+ = D-glucono-1,5-lactone + NADPH + H+ [RN:R07147];
(2) D-galactopyranose + NADP+ = D-galactono-1,5-lactone + NADPH + H+ [RN:R01096]
Reaction(KEGG)
Substrate
D-glucopyranose [CPD:C00031];
NADP+ [CPD:C00006];
D-galactopyranose [CPD:C00124]
Product
D-glucono-1,5-lactone [CPD:C00198];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-galactono-1,5-lactone [CPD:C02669]
Comment
A zinc protein. The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. It shows 20-fold higher activity with NADP+ compared to NAD+. The oxidation of D-glucose and D-galactose is catalysed at a comparable rate (cf. EC 1.1.1.119, glucose 1-dehydrogenase (NADP+) and EC 1.1.1.120, galactose 1-dehydrogenase (NADP+)).
History
EC 1.1.1.360 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K18124  glucose/galactose 1-dehydrogenase (NADP+)
Genes
TAC: Ta0897
TVO: TVG1073292(TVG1073292)
PTO: PTO1070
FAC: FACI_IFERC01G0298
FAI: FAD_1215
CDIV: CPM_0706
Taxonomy
Reference
1  [PMID:15691337]
  Authors
Angelov A, Futterer O, Valerius O, Braus GH, Liebl W
  Title
Properties of the recombinant glucose/galactose dehydrogenase from the extreme thermoacidophile, Picrophilus torridus.
  Journal
FEBS J 272:1054-62 (2005)
DOI:10.1111/j.1742-4658.2004.04539.x
  Sequence
[pto:PTO1070]
Reference
2  [PMID:16556607]
  Authors
Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL
  Title
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
  Journal
J Biol Chem 281:14796-804 (2006)
DOI:10.1074/jbc.M601334200
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.360
IUBMB Enzyme Nomenclature: 1.1.1.360
ExPASy - ENZYME nomenclature database: 1.1.1.360
BRENDA, the Enzyme Database: 1.1.1.360
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