KEGG   ENZYME: 1.1.1.362Help
Entry
EC 1.1.1.362                Enzyme                                 

Name
aklaviketone reductase;
dauE (gene name);
aknU (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
aklavinone:NADP+ oxidoreductase
Reaction(IUBMB)
aklavinone + NADP+ = aklaviketone + NADPH + H+ [RN:R06682]
Reaction(KEGG)
R06682;
(other) R06677
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Substrate
aklavinone [CPD:C12424];
NADP+ [CPD:C00006]
Product
aklaviketone [CPD:C12423];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
History
EC 1.1.1.362 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K15944  nogalaviketone/aklaviketone reductase
Genes
MAU: Micau_4000
MIL: ML5_4421
Taxonomy
Reference
1  [PMID:8655529]
  Authors
Dickens ML, Ye J, Strohl WR.
  Title
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
  Journal
J Bacteriol 178:3384-8 (1996)
DOI:10.1128/JB.178.11.3384-3388.1996
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.362
IUBMB Enzyme Nomenclature: 1.1.1.362
ExPASy - ENZYME nomenclature database: 1.1.1.362
BRENDA, the Enzyme Database: 1.1.1.362
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