KEGG   ENZYME: 1.1.1.368
Entry
EC 1.1.1.368                Enzyme                                 

Name
6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-hydroxycyclohex-1-ene-1-carbonyl-CoA:NAD+ 6-oxidoreductase
Reaction(IUBMB)
6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ = 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+ [RN:R05581]
Reaction(KEGG)
R05581
Substrate
6-hydroxycyclohex-1-ene-1-carbonyl-CoA [CPD:C06749];
NAD+ [CPD:C00003]
Product
6-oxocyclohex-1-ene-1-carbonyl-CoA [CPD:C09821];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme participates in the central benzoyl-CoA degradation pathway of some anaerobic bacteria such as Thauera aromatica.
History
EC 1.1.1.368 created 2014
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07538  6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Genes
SHD: SUTH_01655(had)
EBA: ebA5297(had)
AZA: AZKH_2148(had_bzdX)
AZI: AzCIB_1613 AzCIB_4485
AZD: CDA09_12105(had) CDA09_21785(had)
TMZ: Tmz1t_2954 Tmz1t_4042
TCL: Tchl_2144 Tchl_3418
TAK: Tharo_1302 Tharo_3372
GME: Gmet_2151(bamQ)
GBM: Gbem_1431(bamQ)
GEO: Geob_0097(bamQ)
GEM: GM21_2823
DTO: TOL2_C03830(had)
DALK: DSCA_13410
SAT: SYN_01655
RVA: Rvan_0034
BLAG: BLTE_16540
MAG: amb2144
MAGX: XM1_2899
MAGN: WV31_08585
 » show all
Reference
1  [PMID:10406950]
  Authors
Laempe D, Jahn M, Fuchs G
  Title
6-Hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase and 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase, enzymes of the benzoyl-CoA pathway of anaerobic aromatic metabolism in the denitrifying bacterium Thauera aromatica.
  Journal
Eur J Biochem 263:420-9 (1999)
DOI:10.1046/j.1432-1327.1999.00504.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.368
IUBMB Enzyme Nomenclature: 1.1.1.368
ExPASy - ENZYME nomenclature database: 1.1.1.368
BRENDA, the Enzyme Database: 1.1.1.368
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