KEGG   ENZYME: 1.1.1.392Help
Entry
EC 1.1.1.392                Enzyme                                 

Name
3alpha-hydroxycholanate dehydrogenase (NADP+);
alpha-hydroxy-cholanate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
lithocholate:NADP+ 3-oxidoreductase
Reaction(IUBMB)
lithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+ [RN:R11145]
Reaction(KEGG)
Substrate
lithocholate [CPD:C03990];
NADP+ [CPD:C00006]
Product
3-oxo-5beta-cholan-24-oate [CPD:C03070];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+).
History
EC 1.1.1.392 created 2016
Pathway
ec00121  Secondary bile acid biosynthesis
Orthology
K22605  3alpha-hydroxycholanate dehydrogenase (NADP+)
Genes
CPF: CPF_1154
CPR: CPR_0991
Taxonomy
Reference
1  [PMID:26192599]
  Authors
Devlin AS, Fischbach MA
  Title
A biosynthetic pathway for a prominent class of microbiota-derived bile acids.
  Journal
Nat Chem Biol 11:685-90 (2015)
DOI:10.1038/nchembio.1864
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.392
IUBMB Enzyme Nomenclature: 1.1.1.392
ExPASy - ENZYME nomenclature database: 1.1.1.392
BRENDA, the Enzyme Database: 1.1.1.392
CAS: 9028-57-3
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