Entry |
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Name |
bacteriochlorophyllide a dehydrogenase;
bchC (gene name)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
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Reaction(IUBMB) |
(1) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+ [RN: R09055];
(2) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+
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Reaction(KEGG) |
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Substrate |
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a [CPD: C18153];
NAD+ [CPD: C00003];
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a [CPD: C18154]
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Product |
bacteriochlorophyllide a [CPD: C18155];
NADH [CPD: C00004];
H+ [CPD: C00080];
3-acetyl-3-devinylchlorophyllide a
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Comment |
The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.
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History |
EC 1.1.1.396 created 2016
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Pathway |
ec00860 | Porphyrin and chlorophyll metabolism |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K11337 | bacteriochlorophyllide a dehydrogenase |
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Genes |
» show all
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Reference |
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Authors |
Wellington CL, Beatty JT |
Title |
Promoter mapping and nucleotide sequence of the bchC bacteriochlorophyll biosynthesis gene from Rhodobacter capsulatus. |
Journal |
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Sequence |
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Reference |
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Authors |
McGlynn P, Hunter CN |
Title |
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides. |
Journal |
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Sequence |
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Reference |
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Authors |
Lange C, Kiesel S, Peters S, Virus S, Scheer H, Jahn D, Moser J |
Title |
Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.396 |
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LinkDB |
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