Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)

(1) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+ [RN:R09055];
(2) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+

R09055

3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a [CPD:C18153];
NAD+ [CPD:C00003];
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a [CPD:C18154]

The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.

EC 1.1.1.396 created 2016

1  [PMID:2555268]

Wellington CL, Beatty JT

Promoter mapping and nucleotide sequence of the bchC bacteriochlorophyll biosynthesis gene from Rhodobacter capsulatus.

Gene 83:251-61 (1989)
DOI:10.1016/0378-1119(89)90111-X

[rcp:RCAP_rcc00686]

2  [PMID:8437569]

McGlynn P, Hunter CN

Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.

Mol Gen Genet 236:227-34 (1993)
DOI:10.1007/BF00277117

[rsp:RSP_0263]

3  [PMID:26088139]

Lange C, Kiesel S, Peters S, Virus S, Scheer H, Jahn D, Moser J

Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a.

J Biol Chem 290:19697-709 (2015)
DOI:10.1074/jbc.M115.660555

[cte:CT1422]