KEGG   ENZYME: 1.1.1.403
Entry
EC 1.1.1.403                Enzyme                                 

Name
D-threitol dehydrogenase (NAD+);
dthD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-threitol:NAD+ oxidoreductase
Reaction(IUBMB)
D-threitol + NAD+ = D-erythrulose + NADH + H+ [RN:R11342]
Reaction(KEGG)
R11342
Substrate
D-threitol [CPD:C16884];
NAD+ [CPD:C00003]
Product
D-erythrulose [CPD:C02022];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of D-threitol.
History
EC 1.1.1.403 created 2016
Orthology
K20900  D-threitol dehydrogenase (NAD+)
Genes
MMC: Mmcs_2791
MKM: Mkms_2835
MJL: Mjls_2818
MGRO: FZ046_20035
MSM: MSMEG_3607
MSG: MSMEI_3523
MSB: LJ00_17940
MSN: LI99_17945
MSH: LI98_17950
MCB: Mycch_5122
MPHL: MPHLCCUG_02600(ped_2)
MVQ: MYVA_1610
MAUU: NCTC10437_00317(fabG3_1)
MMAG: MMAD_30180(dthD)
 » show all
Reference
1  [PMID:26560079]
  Authors
Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA
  Title
A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.
  Journal
J Am Chem Soc 137:14570-3 (2015)
DOI:10.1021/jacs.5b08968
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.403
IUBMB Enzyme Nomenclature: 1.1.1.403
ExPASy - ENZYME nomenclature database: 1.1.1.403
BRENDA, the Enzyme Database: 1.1.1.403
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