KEGG   ENZYME: 1.1.1.412
Entry
EC 1.1.1.412                Enzyme                                 

Name
2-alkyl-3-oxoalkanoate reductase;
oleD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,3S)-2-alkyl-3-hydroxyalkanoate:NADP+ oxidoreductase
Reaction(IUBMB)
a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP+ = an (R)-2-alkyl-3-oxoalkanoate + NADPH + H+ [RN:R11774]
Reaction(KEGG)
R11774
Substrate
(2R,3S)-2-alkyl-3-hydroxyalkanoate [CPD:C21645];
NADP+ [CPD:C00006]
Product
(R)-2-alkyl-3-oxoalkanoate [CPD:C21651];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, found in certain bacterial species, is part of a pathway for the production of olefins.
History
EC 1.1.1.412 created 2017
Orthology
K22320  2-alkyl-3-oxoalkanoate reductase
Genes
ECV: APECO1_3444
ELC: i14_3404
ELD: i02_3404
EEC: EcWSU1_02600(ybjS)
ELG: BH714_08850
ENF: AKI40_3362
AHN: NCTC12129_02971
SFO: Z042_00930
XFA: XF_1825
XFT: PD_1041(wcaG)
XCC: XCC0219(cdh)
XCB: XC_0229
XCP: XCR_4304
XCV: XCV0244(cdh1) XCV2768(cdh2)
XAX: XACM_0224(cdh) XACM_2551(cdh2)
XAC: XAC0238(cdh)
XCI: XCAW_00636(wcaG) XCAW_02250(wcaG)
XOM: XOO3985(XOO3985)
XOO: XOO4216(cdh)
XOP: PXO_03949
XOR: XOC_0334
XAL: XALC_3068
XPH: XppCFBP6546_10725(XppCFBP6546P_10725) XppCFBP6546_19550(XppCFBP6546P_19550)
SML: Smlt0209
SMT: Smal_0171
SMZ: SMD_0179
PSUW: WQ53_07280
PSD: DSC_15425
DKO: I596_3755
PPR: PBPRA1465(PD1041)
PAEV: N297_4504
PAEI: N296_4505
PAEP: PA1S_23700
PAEM: U769_23485
PAEL: T223_24210
PAEG: AI22_10355
PAEC: M802_4502
PAEO: M801_4370
PMY: Pmen_1117
PMK: MDS_1170
PPSE: BN5_3326
PPF: Pput_0957
PPT: PPS_4311
PPI: YSA_06933
PPX: T1E_1928(ybjS)
PPUH: B479_21680
PPUT: L483_26745
PPUN: PP4_08910
PPUD: DW66_4700
PMON: X969_21225
PMOT: X970_20860
PSYR: N018_04915
PFL: PFL_4822
PPRO: PPC_4831
PFS: PFLU_4851
PFB: VO64_1703
PMAN: OU5_4807
PEN: PSEEN1125
PKC: PKB_0891
PSES: PSCI_2914
PSEM: TO66_24680
PSOS: POS17_4799
PANR: A7J50_4618
PSET: THL1_4706
PSIL: PMA3_23555
PALL: UYA_05290
SON: SO_1745(oleD)
SDN: Sden_1372
SFR: Sfri_1368
SAZ: Sama_1185
SBL: Sbal_1553
SLO: Shew_1716
SSE: Ssed_1513
SPL: Spea_2733
SHL: Shal_2817
SWD: Swoo_3156
SWP: swp_3333
SVO: SVI_3042
SPSW: Sps_01974
SBK: SHEWBE_2084(oleD)
CPS: CPS_2156
PIN: Ping_2000
MYA: MORIYA_1233(oleD)
LJR: NCTC11533_01933(galE_2)
MMAI: sS8_0068
TBN: TBH_C0499
BCEN: DM39_6030
PSPU: NA29_01850
BAV: BAV2642
ODI: ODI_R2598
PNA: Pnap_3484
AJS: Ajs_3080
RTA: Rta_10830
GUR: Gura_2007
GLO: Glov_2272
GBM: Gbem_2099
GEO: Geob_3152
GEM: GM21_2119
GEB: GM18_2133
PPD: Ppro_3118
DES: DSOUD_2643(hpnA)
DPS: DP2630
DSF: UWK_02994
DAL: Dalk_2037
DOV: DSCO28_06010(oleD)
DALK: DSCA_08760(oleD)
SAT: SYN_02668
DBR: Deba_0617
BRA: BRADO4824
AOL: S58_28570
MOR: MOC_2962
BVR: BVIR_3144
KVL: KVU_PA0226(galE1)
KVU: EIO_3053
MALU: KU6B_53070
SMAZ: LH19_14935
SSAN: NX02_23460
SECH: B18_14550
BLAS: BSY18_1847
ELI: ELI_00360
SHUM: STHU_10730
BMX: BMS_1438
PMW: B2K_05510
SOR: SOR_1792
STJ: SALIVA_1335(Nsdhl)
MTHN: 4412656_02451(strE_1)
MMOR: MMOR_05010
MAIC: MAIC_50360
NFA: NFA_34580
RER: RER_54030
REY: O5Y_25670
ROP: ROP_45580
REQ: REQ_44810
SRT: Srot_1339
SCT: SCAT_2186
SBH: SBI_01613
SVE: SVEN_5970
SALS: SLNWT_2751
SALU: DC74_181
SPRI: SPRI_1064
STRD: NI25_18845
SRJ: SRO_0256
KSK: KSE_01040t(ksbS1L) KSE_44610(ksbS5) KSE_75700t(ksbS1R)
CMI: CMM_2153
CMS: CMS1846
CMC: CMN_02120
MTS: MTES_0537
ARM: ART_1190
AAU: AAur_2000
ACH: Achl_0448
KRH: KRH_10500
LMOI: VV02_25240
IDO: I598_2612
SERJ: SGUI_1321
MPH: MLP_50970
NCA: Noca_3713
NDK: I601_0264
KFL: Kfla_4587
PSIM: KR76_04780
TCU: Tcur_3650
FAL: FRAAL6652
ACE: Acel_0183
NML: Namu_4242
MMAR: MODMU_2227
KRA: Krad_1680
AMN: RAM_20455
AMM: AMES_3965
AMZ: B737_3965
AOI: AORI_6794
AMYY: YIM_46145
SESP: BN6_38300
KAL: KALB_2258
ASE: ACPL_1982(cdh2)
ACTS: ACWT_1860
CALH: IJ00_17175
CAU: Caur_3530
CAG: Cagg_0549
DGA: DEGR_06480(galE1)
TRA: Trad_1559
CAA: Caka_2479
RBA: RB2884(galE) RB993
PSL: Psta_4275
RUL: UC8_04090(strE_1) UC8_57180
FTJ: FTUN_1522
IPA: Isop_1049
ABAS: ACPOL_1482
EMI: Emin_0447
LBA: Lebu_1738
GBA: J421_1495
PGI: PG_1504
 » show all
Reference
1  [PMID:21958090]
  Authors
Bonnett SA, Papireddy K, Higgins S, del Cardayre S, Reynolds KA
  Title
Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia.
  Journal
Biochemistry 50:9633-40 (2011)
DOI:10.1021/bi201096w
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.412
IUBMB Enzyme Nomenclature: 1.1.1.412
ExPASy - ENZYME nomenclature database: 1.1.1.412
BRENDA, the Enzyme Database: 1.1.1.412
LinkDB

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