KEGG   ENZYME: 1.1.1.424
Entry
EC 1.1.1.424                Enzyme                                 

Name
D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming);
xacA (gene name);
xdh (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)
Reaction(IUBMB)
D-xylose + NADP+ = D-xylono-1,4-lactone + NADPH + H+ [RN:R12643]
Reaction(KEGG)
R12643
Substrate
D-xylose [CPD:C00181];
NADP+ [CPD:C00006]
Product
D-xylono-1,4-lactone [CPD:C02753];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC 1.1.1.179, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming).
History
EC 1.1.1.424 created 2020
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K24442  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Genes
HHB: Hhub_4012 Hhub_4091
HJE: HacjB3_02295 HacjB3_03200 HacjB3_05780
HALR: EFA46_009975 EFA46_010985 EFA46_011180
HMA: pNG7191(gfo2) rrnAC3034(gfo6)
HHI: HAH_0291 HAH_5355(gfo4)
HHN: HISP_01540 HISP_19955
HAB: SG26_09370 SG26_18100
HTA: BVU17_01425 BVU17_16040
HALJ: G9465_01150 G9465_11050
HUT: Huta_2274
HTI: HTIA_1971
HMU: Hmuk_2533
HALL: LC1Hm_1813(xdh)
HWA: HQ_3202A
HWC: Hqrw_3764
HVO: HVO_A0330 HVO_B0028(xacA)
NAT: NJ7G_0683
SALI: L593_08020
 » show all
Reference
1  [PMID:15342590]
  Authors
Johnsen U, Schonheit P
  Title
Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.
  Journal
J Bacteriol 186:6198-207 (2004)
DOI:10.1128/JB.186.18.6198-6207.2004
  Sequence
[hma:rrnAC3034]
Reference
2  [PMID:19584053]
  Authors
Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P
  Title
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
  Journal
J Biol Chem 284:27290-303 (2009)
DOI:10.1074/jbc.M109.003814
  Sequence
[hvo:HVO_B0028]
Reference
3  [PMID:28854683]
  Authors
Sutter JM, Johnsen U, Schonheit P
  Title
Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.
  Journal
FEMS Microbiol Lett 364:3898818 (2017)
DOI:10.1093/femsle/fnx140
  Sequence
[hvo:HVO_B0028]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.424
IUBMB Enzyme Nomenclature: 1.1.1.424
ExPASy - ENZYME nomenclature database: 1.1.1.424
BRENDA, the Enzyme Database: 1.1.1.424
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