KEGG   ENZYME: 1.1.1.45
Entry
EC 1.1.1.45                 Enzyme                                 
Name
L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-gulonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]
Reaction(KEGG)
R02640
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also oxidizes other L-3-hydroxyacids.
History
EC 1.1.1.45 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K13247  L-gulonate 3-dehydrogenase
Genes
HSA51084(CRYL1)
PTR452458(CRYL1)
PPS100972837(CRYL1)
GGO101150176(CRYL1)
PON100171829(CRYL1)
NLE100592398(CRYL1)
HMH116467173(CRYL1)
MCC703988(CRYL1)
MCF102126962(CRYL1)
MTHB126940694
MNI105490295(CRYL1)
CSAB103248964(CRYL1)
CATY105591942(CRYL1)
PANU101001860(CRYL1)
TGE112610999(CRYL1)
MLEU105537044(CRYL1)
RRO104653941(CRYL1)
RBB108519944(CRYL1)
TFN117063326(CRYL1)
PTEH111525293(CRYL1)
CANG105518364(CRYL1)
CJC100412249(CRYL1)
CIMI108317579(CRYL1)
CSYR103270481(CRYL1)
MMUR105878855(CRYL1)
LCAT123649492(CRYL1)
PCOQ105808162(CRYL1)
OGA100952755(CRYL1)
MMU68631(Cryl1)
MCAL110309524(Cryl1)
MPAH110325514(Cryl1)
RNO290277(Cryl1)
MCOC116084687(Cryl1)
ANU117706358(Cryl1)
MUN110549743(Cryl1)
CGE100763866(Cryl1)
MAUA101840819(Cryl1)
PROB127230338(Cryl1)
PLEU114693857(Cryl1)
MORG121435018(Cryl1)
MFOT126507650
AAMP119800418(Cryl1)
NGI103726723(Cryl1)
HGL101708457(Cryl1)
CPOC100724326(Cryl1)
CCAN109695277(Cryl1)
DORD105981591(Cryl1)
DSP122112582(Cryl1)
PLOP125348463(Cryl1)
NCAR124974061 124984686
MMMA107153796(Cryl1)
OCU100009108(CRYL1)
OPI101517946(CRYL1)
TUP102481339(CRYL1)
GVR103596952(CRYL1)
CFA486050(CRYL1)
CLUD112669557(CRYL1)
VVP112918595(CRYL1)
VLG121496631(CRYL1)
NPO129504559(CRYL1)
AML100472061(CRYL1)
UMR103664279(CRYL1)
UAH113251169(CRYL1)
UAR123791990(CRYL1)
ELK111159885
LLV125096155
MPUF101676898(CRYL1)
MNP132002498(CRYL1)
MLK131814134(CRYL1)
NVS122906903(CRYL1)
ORO101365710(CRYL1)
EJU114212937(CRYL1)
ZCA113920010(CRYL1)
MLX118009602(CRYL1)
NSU110570236(CRYL1)
LWW102737160
FCA101092816(CRYL1)
PYU121012709(CRYL1)
PCOO112861589(CRYL1)
PBG122480396(CRYL1)
LRUF124510824
PTG102950829(CRYL1)
PPAD109266190(CRYL1)
PUC125934057
AJU106979799
HHV120226076(CRYL1)
BTA281725(CRYL1)
BOM102271200(CRYL1)
BIU109567054(CRYL1)
BBUB102401582(CRYL1)
BBIS104996804(CRYL1)
CHX102170708(CRYL1)
OAS101118708(CRYL1)
BTAX128057520(CRYL1)
ODA120882971(CRYL1)
CCAD122447415(CRYL1)
MBEZ129556402(CRYL1)
SSC396914(CRYL1)
CFR102509868(CRYL1)
CBAI105066281(CRYL1)
CDK105096393(CRYL1)
VPC102524845(CRYL1)
BACU103009238(CRYL1)
LVE103070582(CRYL1)
OOR101286495(CRYL1)
DLE111175144(CRYL1)
PCAD102986755(CRYL1)
PSIU116742905(CRYL1)
NASI112404839(CRYL1)
ECB100054141(CRYL1)
EPZ103564931(CRYL1)
EAI106828569(CRYL1)
MYB102243403(CRYL1)
MYD102772105(CRYL1)
MMYO118650826(CRYL1)
MLF102433427(CRYL1)
MNA107529957(CRYL1)
PKL118728704(CRYL1)
EFUS103301254(CRYL1)
HAI109388026(CRYL1)
DRO112323170(CRYL1)
SHON118980601(CRYL1)
AJM119042440(CRYL1)
PDIC114513187(CRYL1)
PHAS123822763(CRYL1)
MMF118623484(CRYL1)
RFQ117021303(CRYL1)
PPAM129073787(CRYL1)
PALE102894030(CRYL1)
PGIG120602838(CRYL1)
PVP105292144(CRYL1)
RAY107497671(CRYL1)
MJV108405961(CRYL1)
TOD119258928(CRYL1)
SARA101558948(CRYL1)
LAV100659835(CRYL1)
TMU101345413
ETF101654146(CRYL1)
DNM101445681(CRYL1)
MDO100023498(CRYL1)
GAS123240613(CRYL1)
SHR100917581(CRYL1)
AFZ127554760
PCW110195845(CRYL1)
OAA100089465(CRYL1)
GGA418953(CRYL1)
PCOC116244280(CRYL1)
MGP100551040
CJO107308329(CRYL1)
TPAI128074873(CRYL1)
LMUT125687983(CRYL1)
NMEL110389386(CRYL1)
APLA101793734(CRYL1)
ACYG106040376(CRYL1)
CATA118246009(CRYL1)
AFUL116498931(CRYL1)
TGU100232047(CRYL1)
LSR110475660(CRYL1)
SCAN103827309(CRYL1)
PMOA120506684(CRYL1)
OTC121342022(CRYL1)
PRUF121364257(CRYL1)
GFR102041430(CRYL1)
FAB101817119(CRYL1)
OMA130266126(CRYL1)
PHI102101871(CRYL1)
PMAJ107209122(CRYL1)
CCAE111923791(CRYL1)
CCW104690100(CRYL1)
CBRC103613239(CRYL1)
ETL114057805(CRYL1)
ZAB102061772(CRYL1)
ACHL103811741(CRYL1)
SVG106854023(CRYL1)
MMEA130574956(CRYL1)
HRT120749425(CRYL1)
FPG101922282(CRYL1)
FCH102049266(CRYL1)
CLV102083838(CRYL1)
EGZ104134722(CRYL1)
NNI104023102(CRYL1)
PCRI104026979(CRYL1)
PLET104623628(CRYL1)
EHS104502671(CRYL1)
PCAO104042957
ACUN113482754(CRYL1)
TALA104361260(CRYL1)
PADL103920202(CRYL1)
AFOR103898984(CRYL1)
ACHC115353354(CRYL1)
HALD104319372(CRYL1)
HLE104835018(CRYL1)
AGEN126048189
GCL127020556
CCRI104156172(CRYL1)
CSTI104563835(CRYL1)
MUI104547596(CRYL1)
BREG104635198(CRYL1)
FGA104075928(CRYL1)
LDI104344006(CRYL1)
MNB103769606(CRYL1)
OHA104337317(CRYL1)
NNT104403386(CRYL1)
SHAB115604612(CRYL1)
DPUB104303387(CRYL1)
PGUU104457915(CRYL1)
ACAR104523600(CRYL1)
CPEA104390330(CRYL1)
AVIT104272082(CRYL1)
CVF104291416(CRYL1)
RTD128914464(CRYL1)
CUCA104055323(CRYL1)
TEO104380946(CRYL1)
BRHI104495516(CRYL1)
AAM106500417(CRYL1)
AROW112968342(CRYL1)
NPD112943768(CRYL1)
TGT104576285(CRYL1)
DNE112990415(CRYL1)
SCAM104151655(CRYL1)
ASN102385817(CRYL1)
AMJ102567690(CRYL1)
CPOO109306668(CRYL1)
GGN109302917(CRYL1)
PSS102463965(CRYL1)
CMY102935894(CRYL1)
CCAY125634502(CRYL1)
DCC119849943(CRYL1)
CPIC101933946(CRYL1)
TST117871124(CRYL1)
CABI116816440(CRYL1)
MRV120399237(CRYL1)
ACS100564118(cryl1)
ASAO132772155(CRYL1)
PVT110083538(CRYL1)
SUND121924941(CRYL1)
PBI103051802(CRYL1)
PMUR107286120(CRYL1)
CTIG120311692(CRYL1)
TSR106551499(CRYL1)
PGUT117661337(CRYL1)
APRI131199514(CRYL1)
PTEX113441656(CRYL1)
NSS113416942(CRYL1)
VKO123029093(CRYL1)
PMUA114595713(CRYL1)
PRAF128412647(CRYL1)
ZVI118085139(CRYL1)
HCG128352128(CRYL1)
GJA107125996(CRYL1)
STOW125430493(CRYL1)
EMC129325720(CRYL1)
XLA100036971(cryl1.L) 108709973(cryl1.S)
XTR100145620(cryl1)
NPR108785578(CRYL1)
RTEM120929241(CRYL1)
BBUF120996355(CRYL1)
BGAR122930603(CRYL1)
MUO115468518(CRYL1)
GSH117363113(CRYL1)
DRE751596(cryl1)
SRX107712274 107724506
SANH107658254 107668879
SGH107569147(cryl1) 107597421
CCAR109064376 109096349
CAUA113053392 113071898 113108802
CGIB127965416 128019711
PTET122351364(cryl1)
LROH127170807(cryl1)
OMC131547508(cryl1)
PPRM120467043(cryl1)
RKG130076292(cryl1)
MAMB125270524(cryl1)
CIDE127518659
MASI127447534
TROS130556150(cryl1)
TDW130427123(cryl1)
MANU129451521(cryl1)
IPU100528270(cryl1)
IFU128609128(cryl1)
PHYP113526091(cryl1)
SMEO124380707(cryl1)
TFD113654286(cryl1)
TVC132850061(cryl1)
AMEX103023213(cryl1)
CMAO118798664(cryl1)
EEE113588651(cryl1)
CHAR105913276(cryl1)
TRU101068058(cryl1)
TFS130531078(cryl1)
TNGGSTEN00029164G001
LCO104934840(cryl1)
NCC104945644(cryl1)
TBEN117495726(cryl1)
CGOB115026817(cryl1)
PGEO117467053(cryl1)
GACU117536549(cryl1)
ELY117248914(cryl1)
EFO125900209(cryl1)
PLEP121948948(cryl1)
SLUC116062300(cryl1)
ECRA117953287(cryl1)
ESP116698185(cryl1)
PFLV114564208(cryl1)
GAT120833953(cryl1)
PPUG119229346(cryl1)
AFB129105142(cryl1)
CLUM117750319(cryl1)
MSAM119904472(cryl1)
SCHU122885354(cryl1)
CUD121522650(cryl1)
ALAT119025838(cryl1)
MZE101465841 112436192 112436206(cryl1)
ONL100691411(cryl1)
OAU116332577(cryl1)
OLA101157739(cryl1)
OML112155251(cryl1)
XMA102230923(cryl1)
XCO114148696(cryl1)
XHE116723531(cryl1)
PRET103478202(cryl1)
PFOR103156381(cryl1)
PLAI106935265(cryl1)
PMEI106903604(cryl1)
GAF122839853(cryl1)
PPRL129361549(cryl1)
CVG107087357(cryl1)
CTUL119772901(cryl1)
GMU124871079(cryl1)
NFU107389625(cryl1)
KMR108244181(cryl1)
ALIM106524932(cryl1)
NWH119419355(cryl1)
AOCE111581663(cryl1)
MCEP125017187(cryl1)
CSEM103391958(cryl1)
POV109637940(cryl1)
SSEN122761091(cryl1)
HHIP117755164(cryl1)
HSP118120347(cryl1)
LCF108897026
SDU111218259(cryl1)
SLAL111652885(cryl1)
XGL120801727(cryl1)
HCQ109522065(cryl1)
SSCV125974247
SBIA133512309(cryl1)
PEE133410725(cryl1)
PTAO133486805(cryl1)
BPEC110162057(cryl1)
MALB109970945(cryl1)
BSPL114847366(cryl1)
SJO128367834(cryl1)
SASA100195418(cryl1)
STRU115156346 115161087(cryl1)
OTW112240524(cryl1)
OMY110520403(cryl1)
OGO124044093(cryl1)
ONE115112116(cryl1)
OKI109869173(cryl1)
OKE118371557(cryl1)
SALP111978533(cryl1)
SNH120058412(cryl1)
CCLU121536894 121571699
ELS105016416(cryl1)
SFM108937705(cryl1)
PKI111860704(cryl1)
AANG118214554(cryl1) 118223981
LOC102684363(cryl1)
PSPA121320467(cryl1) 121327669
ARUT117406054(cryl1) 117406863
PSEX120523053(cryl1)
LCM102362253(CRYL1)
CMK103186496(cryl1)
RTP109930659(cryl1)
CPLA122550734(cryl1)
HOC132816777(cryl1)
LERI129698105(cryl1)
PMRN116952884(CRYL1)
LRJ133353335(CRYL1)
BFO118422602
BBEL109488016
CIN100176260
SCLV120336091
SPU115928294 577306 589657
LPIC129259089
APLC110981494 110981535 110981536
AJC117112751
SKO100374307
DMEDmel_CG10131(Had2) Dmel_CG9914(Had1)
DER6548822 6550539
DSE6609182 6617912
DSIDsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)
DYADyak_GE11007 Dyak_GE13601
DAN6494200 6501835
DSR110180150 110191959
DPO4803972 6901728
DPE6590724 6603093
DMN108158253 108159363 117190757
DWI6639842 6648665
DGR6565348 6568938
DMODmoj_GI10976 Dmoj_GI18410
DAZ108617572 108619199
DNV108653241 108656753
DHE111592192 111595367
DVI6626866 6636728
CCAT101453450 101456276 101456789
BOD106622355 106626802
BDR105224947 105228395
RZE108364165 108375522 108381713
AOQ129238597 129244849
TDA119667107 119667108 119676101 119682608 119682951
MDE101888499 101897214 131805575
SCAC106086914 106086916 106093808
LCQ111679870 111686013
LSQ119600618 119605148 119615754
GFS119638315
ECOE129952894
CLON129610727
HIS119661460
AGA11175486
ACOZ120948141
AARA120894717
AMER121592708
ASTE118510134 118516924
AFUN125771329
AMOU128304935
AALI118466302
AAG5569895
AALB109399229
CQUCpipJ_CPIJ018047 CpipJ_CPIJ019115
CPII120422649 120431521
CNS116347304
BCOO119080762
AME406119(Cryl1)
ACER107995494
ALAB122710384
ADR102675628
AFLR100871991
BIM100742533
BBIF117211061
BVK117232137
BVAN117157796
BTER100650820
BAFF126921377
BPYO122573401
BPAS132904573
FVI122527338
CCAL108626681 108629961
OBB114882990 114883008
OLG117609123
MGEN117225661
NMEA116424552
CGIG122395521
SOC105195706
MPHA105832446
AEC105144455
ACEP105622538
PBAR105431786
VEM105561636 105570417
HST105183285
DQU106741081
CFO105257467
FEX115235110
LHU105668733
PGC109852151
OBO105282065
PCF106785654
PFUC122516905
VPS122628397
VCRB124425275
NVI100116345
CSOL105360276
TPRE106659815
LHT122504281
LBD127287131
MDL103573914
CGLO123268844
FAS105266907
DAM107045947
AGIF122850047
CINS118067447
VCAN122409191
CCIN107265976
DSM124404941
NPT124222898
NFB124185458
NLO107227394
NVG124310411
AROA105688895
TCA656318
DPA109541128
SOY115878469
ATD109601505
CSET123306830
AGB108906080 108906095
LDC111509970
NVL108558442
APLN108736178
PPYR116168479
OTU111416084
BMOR101740023
BMAN114241018
MSEX115441101
DPLKGM_211998
BANY112043720
MJU123867210
NIQ126768828
VCD124530582
MCIX123654539 123654606 123654607
PMAC106716619
PPOT106100831
PXU106125533
PRAP110996894
PBX123708022
PNAP125051352
ZCE119831471
CCRC123692353
LSIN126968223
HAW110375292
HZE124630756
TNL113502390
SLIU111349675
OFU114360575
PXY105383308 105396444
PGW126367175
CFEL113389158 113389184
CCRN123291514
API100160442
DNX107163082
AGS114126889
RMD113556888
ACOO126846632
DVT126895480
BTAB109030675
DCI103512794 103524139
CLEC106668054
HHAL106682907
NLU111048337 120355770
HVI124353642
MQU129003956
PHUPhum_PHUM424710
FOC113203906 113211664
TPAL117640202 117643446
ZNE110836645
CSEC111870196
SGRE126282026
IEL124161524
FCD110850841
DPXDAPPUDRAFT_306692
DMK116922972
DPZ124321193
PVM113820593
PJA122250216
PCHN125046015
PMOO119590590
HAME121868225
PCLA123764372
CQD128688043
PTRU123499754
ESN127004343
HAZT108673194
EAF111704761
TCF131881953
PPOI119102644 119102645 119103678
DSV119460873
RSAN119396684 119396685
RMP119174841
VDE111248233
VJA111271569
TUT107361139 107363503 107363504 107371216
DPTE113788736 113788737
DFR124496926
CSCU111638201
PTEP107448274 107452836 122273100
UDV129227487 129227929
SDM118202986
LPOL106476335
PMEO129584817
CELCELE_Y71F9B.9(Y71F9B.9)
CBRCBG_04121
CRQGCK72_002081
NAINECAME_01388
LGILOTGIDRAFT_189928 LOTGIDRAFT_95422
PVUL126811574 126811575
PCAN112555792 112565739 112566077 112566843
BGT106064558 106073430
GAE121369917 121370830 121370832 121372140 121372142 121372193
HRF124147345 124147347 124147351
HRJ124282586 124282594 124282598 124282607 124283055
CRG105330247 105336911 117690734 117690735 117690897
CVN111105314
CANU128184312 128185658
OED125676954 125677741
MYI110448022 110457594 110457605
PMAX117326996 117326998 117341359
MCAF127725915 127725999
MMER123551220 123551221 123551632 123560311
RPHI132714004 132714005 132714009 132735099 132735100 132759311 132759312
DPOL127831939 127850024 127879725
OBI106873772
OSN115228137
LAK106152168 106168383
NVE5510436
EPA110235936
ATEN116303602
ADF107344229
AMIL114975193
PDAM113664513
SPIS111325818
DGT114534577
XEN124441295 124442623
HMG100202070
HSY130645359
AQU100640580
MBRMONBRDRAFT_2035
SREPTSG_04984
 » show all
Reference
1
  Authors
Dworsky, P. and Hoffmann-Ostenhof, O.
  Title
L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.
  Journal
Acta Biochim Pol 11:269-277 (1964)
Reference
2
  Authors
Smiley, J.D. and Ashwell, G.
  Title
Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.
  Journal
J Biol Chem 236:357-364 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.45
IUBMB Enzyme Nomenclature: 1.1.1.45
ExPASy - ENZYME nomenclature database: 1.1.1.45
BRENDA, the Enzyme Database: 1.1.1.45
CAS: 9028-51-7
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