ENZYME: 1.1.1.61
Help
Entry
EC 1.1.1.61 Enzyme
Name
4-hydroxybutyrate dehydrogenase;
gamma-hydroxybutyrate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxybutanoate:NAD+ oxidoreductase
Reaction(IUBMB)
4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH + H+ [RN:
R01644
]
Reaction(KEGG)
R01644
Reaction
Substrate
4-hydroxybutanoate [CPD:
C00989
];
NAD+ [CPD:
C00003
]
Product
succinate semialdehyde [CPD:
C00232
];
NADH [CPD:
C00004
];
H+ [CPD:
C00080
]
History
EC 1.1.1.61 created 1965
Pathway
ec00650
Butanoate metabolism
ec01100
Metabolic pathways
Orthology
K00043
4-hydroxybutyrate dehydrogenase
K08318
4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase
K18120
4-hydroxybutyrate dehydrogenase
Genes
ECO:
b3882
(yihU)
ECJ:
JW3853
(yihU)
ECD:
ECDH10B_4072
(yihU)
EBW:
BWG_3552
(yihU)
ECOK:
ECMDS42_3321
(yihU)
ECE:
Z5420
(yihU)
ECS:
ECs4805
ECF:
ECH74115_5329
ETW:
ECSP_4938
(yihU)
ELX:
CDCO157_4544
EOI:
ECO111_4702
(yihU)
EOJ:
ECO26_4708
(yihU)
EOH:
ECO103_4289
(yihU)
ESL:
O3K_24495
ESO:
O3O_00840
ESM:
O3M_24415
ECK:
EC55989_4353
ECG:
E2348C_4180
EOK:
G2583_4683
(yihU)
ELR:
ECO55CA74_22435
ELH:
ETEC_4152
ECW:
EcE24377A_4405
EUN:
UMNK88_4715
ECP:
ECP_4088
ENA:
ECNA114_3975
(yihU)
ECOS:
EC958_4354
(yihU)
ECV:
APECO1_2588
ECOA:
APECO78_00150
ECX:
EcHS_A4104
ECM:
EcSMS35_4267
ECY:
ECSE_4165
ECR:
ECIAI1_4082
(yihU)
ECQ:
ECED1_4582
(yihU)
EUM:
ECUMN_4409
(yihU)
ECT:
ECIAI39_3118
(yihU)
EOC:
CE10_4546
(yihU)
EBR:
ECB_03767
(yihU)
EBL:
ECD_03767
(yihU)
EBE:
B21_03716
(yihU)
EBD:
ECBD_4145
ECI:
UTI89_C4463
(yihU)
EIH:
ECOK1_4346
ECZ:
ECS88_4324
ECC:
c4826
(yihU)
ELO:
EC042_4256
ELN:
NRG857_19350
ESE:
ECSF_3733
ECL:
EcolC_4139
EKO:
EKO11_4480
EKF:
KO11_03195
(yihU)
EAB:
ECABU_c43810
EDH:
EcDH1_4104
EDJ:
ECDH1ME8569_3753
(yihU)
ELU:
UM146_19610
ELW:
ECW_m4186
(yihU)
ELL:
WFL_20395
(yihU)
ELC:
i14_4419
(yihU)
ELD:
i02_4419
(yihU)
ELP:
P12B_c3997
ELF:
LF82_610
ECOL:
LY180_20115
ECOI:
ECOPMV1_04237
(garR_4)
ECOJ:
P423_21510
EMA:
C1192_16095
ESZ:
FEM44_09220
(yihU)
STY:
STY3855
(yihU)
STT:
t3598
(yihU)
SEX:
STBHUCCB_37870
SENT:
TY21A_18195
STM:
STM4023
(yihU)
SEO:
STM14_4836
(yihU)
SEV:
STMMW_39871
SEY:
SL1344_3969
(yihU)
SEM:
STMDT12_C41660
SEJ:
STMUK_4006
(yihU)
SEB:
STM474_4200
(yihU)
SEF:
UMN798_4360
(yihU)
SETU:
STU288_20245
SETC:
CFSAN001921_20325
SENR:
STMDT2_38831
(yihU)
SEND:
DT104_40301
(yihU)
SENI:
CY43_21025
SEEN:
SE451236_00795
SPT:
SPA3864
(yihU)
SEK:
SSPA3594
SPQ:
SPAB_04982
SEI:
SPC_4126
(yihU)
SEC:
SCH_3913
(yihU)
SEH:
SeHA_C4346
SHB:
SU5_0119
SENH:
CFSAN002069_11975
SEEH:
SEEH1578_06140
SEE:
SNSL254_A4300
SENN:
SN31241_47150
SEW:
SeSA_A4233
SEA:
SeAg_B4255
SENS:
Q786_19720
SED:
SeD_A4411
SEG:
SG3402
(yihU)
SEL:
SPUL_3649
(yihU)
SEGA:
SPUCDC_3635
(yihU)
SET:
SEN3811
(yihU)
SENA:
AU38_19695
SENO:
AU37_19710
SENV:
AU39_19730
SENQ:
AU40_22020
SENL:
IY59_20190
SENJ:
CFSAN001992_13600
SEEC:
CFSAN002050_02990
SEEB:
SEEB0189_022240
SEEP:
I137_17525
SENB:
BN855_40890
SENE:
IA1_19550
SENC:
SEET0819_03940
SES:
SARI_03643
SBG:
SBG_3540
(yihU)
SBZ:
A464_4064
SBV:
N643_17755
SALZ:
EOS98_22210
SFL:
SF3954
(yihU)
SFX:
S3792
(yihU)
SFV:
SFV_3617
(yihU)
SFE:
SFxv_4308
(yihU)
SFN:
SFy_5649
SFS:
SFyv_5712
SFT:
NCTC1_04280
(yihU)
SSN:
SSON_4048
(yihU)
SBO:
SBO_3887
(yihU)
SHQ:
A0259_00965
ENC:
ECL_05103
ECLG:
EC036_44050
ECLE:
ECNIH2_23255
ECLN:
ECNIH4_22495
ECLI:
ECNIH5_21760
ECLX:
LI66_22510
ECLY:
LI62_24595
ECLZ:
LI64_21625
ECLO:
ENC_00300
EHM:
AB284_04510
EXF:
BFV63_21885
ECLA:
ECNIH3_21835
ECLC:
ECR091_21765
EAU:
DI57_18815
EKB:
BFV64_23245
ENO:
ECENHK_21935
EEC:
EcWSU1_04480
(yihU)
ELG:
BH714_14860
ECAN:
CWI88_22490
ERN:
BFV67_21865
ECLS:
LI67_024265
ECHG:
FY206_24275
(yihU)
EAS:
Entas_4393
EBG:
FAI37_07030
(yihU)
END:
A4308_06885
ESA:
ESA_04058
CSK:
ES15_0037
CSZ:
CSSP291_18805
CSJ:
CSK29544_00987
CCON:
AFK62_19810
CSI:
P262_05706
CMJ:
AFK66_000210
CUI:
AFK65_19600
CMW:
AFK63_18745
CTU:
CTU_41740
(yihU)
KLW:
DA718_29160
CRO:
ROD_38791
CKO:
CKO_03131
CFD:
CFNIH1_06955
CBRA:
A6J81_16395
CWE:
CO701_21335
CYO:
CD187_23365
CPOT:
FOB25_10635
(yihU)
CFQ:
C2U38_25190
CAMA:
F384_21000
CAF:
AL524_03835
CIF:
AL515_02035
CFAR:
CI104_24475
CIR:
C2U53_10580
CIE:
AN232_03630
CPAR:
CUC49_19980
ESC:
Entcl_1241
LAX:
APT61_00220
LEI:
C2U54_04485
LEE:
DVA44_23385
LER:
GNG29_22755
(yihU)
LEA:
GNG26_22095
(yihU)
LAZ:
A8A57_21395
LNI:
CWR52_12850
BAGE:
BADSM9389_41410
AHN:
NCTC12129_04955
(garR_2)
KIN:
AB182_24960
YAL:
AT01_41
SFW:
WN53_01445
SFG:
AV650_24195
SFO:
Z042_05670
RAH:
Rahaq_4078
RAQ:
Rahaq2_4181
RAA:
Q7S_20720
PAM:
PANA_3497
(yihU)
PLF:
PANA5342_0554
(yihU)
PAJ:
PAJ_2726
(yihU)
PAQ:
PAGR_g0536
PSTW:
DSJ_21395
MTHI:
C7M52_01008
(yihU)
HPAR:
AL518_02780
PRAG:
EKN56_14665
LRI:
NCTC12151_00811
(Hgd)
BSUN:
A4G13_00755
VSH:
BSZ05_23595
PMK:
MDS_0271
PPF:
Pput_2157
PPG:
PputGB1_3155
PPB:
PPUBIRD1_3027
PPI:
YSA_00253
PPX:
T1E_2653
(dhaT)
PPUT:
L483_10705
PPUN:
PP4_31900
(gbd)
POR:
APT59_05510
PVR:
PverR02_11545
PLUL:
FOB45_03485
PPSL:
BJP27_20245
PSIL:
PMA3_16430
PALL:
UYA_00985
AEI:
AOY20_11465
MSR:
AU15_05055
SROS:
BBH56_04580
CSA:
Csal_1756
HEL:
HELO_1042
HAK:
KO116_02309
HALO:
BWR19_00250
BWR19_04415
HTT:
HZS52_00870
HZS52_09090
AXE:
P40_19220
THIN:
CRN91_08445
RSO:
RSc1771
(gbd1)
RSp0986
(gbd2)
RSC:
RCFBP_11780
RSL:
RPSI07_1814
RPSI07_mp0978
RSN:
RSPO_c01807
(gbd1)
RSPO_m01535
(gbd2)
RSM:
CMR15_11780
CMR15_mp20069
RSE:
F504_1618
F504_4216
RSY:
RSUY_19640
(dhaT_1)
RSUY_45330
(dhaT_2)
RPI:
Rpic_1435
RPF:
Rpic12D_1476
RPJ:
N234_07690
N234_11110
N234_25710
RMN:
TK49_11475
RIN:
ACS15_1682
RPU:
CDC45_09125
CDC45_22570
REH:
H16_A1553
(gbd)
CNC:
CNE_1c15720
(gbd1)
CNE_2c21420
(dhaT)
CUH:
BJN34_07770
BJN34_35670
BJN34_36185
REU:
Reut_A1418
CTI:
RALTA_A1479
(gbd1)
RALTA_A1654
CBW:
RR42_m2218
CGD:
CR3_1469
(gbd)
CCUP:
BKK81_11130
CUP:
BKK80_11385
CUU:
BKK79_01450
COX:
E0W60_17505
E0W60_19295
E0W60_28535
BMA:
BMA0905
BMV:
BMASAVP1_A1435
BML:
BMA10229_A0445
BMN:
BMA10247_0717
BMAL:
DM55_2122
BMAE:
DM78_2160
BMAQ:
DM76_2097
BMAI:
DM57_2961
BMAF:
DM51_660
BMAZ:
BM44_2344
BMAB:
BM45_1909
BPS:
BPSL2002
BPM:
BURPS1710b_1823
(gbd1)
BPL:
BURPS1106A_1668
BPD:
BURPS668_1646
BPR:
GBP346_A1691
BPSE:
BDL_538
BPSM:
BBQ_1873
BPSU:
BBN_1999
BPSD:
BBX_2477
BPZ:
BP1026B_I1971
BPQ:
BPC006_I1715
BPK:
BBK_48
BPSH:
DR55_3113
BPSA:
BBU_708
BPSO:
X996_2727
BUT:
X994_1181
BTE:
BTH_I2655
BTQ:
BTQ_1369
BTJ:
BTJ_1083
BTZ:
BTL_2324
BTD:
BTI_2398
BTV:
BTHA_2523
BTHE:
BTN_2444
BTHM:
BTRA_2604
BTHA:
DR62_2589
BTHL:
BG87_2548
BOK:
DM82_940
BOC:
BG90_3662
BUU:
WS70_10220
BYI:
BYI23_C013470
BYI23_D009270
BUE:
BRPE67_CCDS13020
BRPE67_DCDS11290
BUL:
BW21_2365
BUD:
AQ610_11175
BUM:
AXG89_00640
AXG89_13410
BUI:
AX768_07270
AX768_10380
BXE:
Bxe_A1316
BXB:
DR64_3477
BPH:
Bphy_1609
BGE:
BC1002_2056
BFN:
OI25_3878
BCAI:
K788_0004323
K788_0005638
PSPW:
BJG93_02060
PARA:
BTO02_14775
PARB:
CJU94_10860
PHS:
C2L64_05070
C2L64_35875
PTER:
C2L65_04865
C2L65_18360
PMEG:
FNZ07_26230
PPK:
U875_19915
PPNO:
DA70_12605
PPNM:
LV28_18090
PRB:
X636_14260
PPUL:
RO07_03920
PSPU:
NA29_15990
PVE:
UC34_12605
POX:
MB84_16990
PTX:
ABW99_06350
CABA:
SBC2_25090
(dhaT_1)
BUO:
BRPE64_DCDS02300
BRPE64_DCDS08060
BPAR:
BN117_1237
(gbd)
BPA:
BPP2084
(gbd)
BBH:
BN112_1980
(gbd)
BN112_4333
BBR:
BB1480
(gbd)
BB4070
BBM:
BN115_1435
(gbd)
BN115_3759
BBX:
BBS798_1441
(gbd)
BBS798_3863
BBRO:
BAU06_13910
BFZ:
BAU07_12355
BGM:
CAL15_12665
AXY:
AXYL_01396
AIS:
BUW96_16295
BUW96_19440
ASW:
CVS48_11670
AKA:
TKWG_00120
ODI:
ODI_R3947
PACR:
FXN63_01020
FXN63_12020
RSB:
RS694_10575
RHY:
RD110_09325
RD110_14010
RHF:
EUB48_10405
POL:
Bpro_2526
PNA:
Pnap_1943
POS:
DT070_16925
POO:
F7R28_13660
AAV:
Aave_3418
AJS:
Ajs_1711
DIA:
Dtpsy_1993
AAA:
Acav_1813
ACK:
C380_00980
C380_10655
ACRA:
BSY15_1622
BSY15_3223
ACID:
CBP33_08840
ACIP:
CBP36_00930
CBP36_11490
ACIN:
CBP34_08425
ACIS:
CBP35_07440
CBP35_18025
ACIO:
EAG14_09075
DAC:
Daci_3383
DEL:
DelCs14_3386
DTS:
BI380_02590
DHK:
BO996_15510
DLA:
I6G47_06755
VAP:
Vapar_2864
VPE:
Varpa_3110
VPD:
VAPA_1c26910
VAA:
AX767_19875
VBO:
CKY39_17110
VAM:
C4F17_04985
CTT:
CtCNB1_1590
CtCNB1_3095
CTES:
O987_09340
CKE:
B5M06_12990
CSER:
CCO03_12395
ADN:
Alide_0276
ADK:
Alide2_0223
RTA:
Rta_19890
OTK:
C6570_11685
LIM:
L103DPR2_01788
(dhaT_2)
LIH:
L63ED372_01374
(dhaT)
HYR:
BSY239_1702
HYB:
Q5W_09540
HYL:
LPB072_10990
HYC:
E5678_05855
HPSE:
HPF_11925
(mdh2)
HYN:
F9K07_12760
F9K07_14800
DPY:
BA022_03250
DIH:
G7047_09480
G7047_12135
DAER:
H9K75_01440
H9K75_23190
DRG:
H9K76_12430
SIMP:
C6571_16485
MELM:
C7H73_08270
CBAA:
SRAA_1594
CBAB:
SMCB_1500
STHM:
IS481_09110
MPT:
Mpe_A1798
METP:
C1M51_18570
JAJ:
EKL02_00520
HSE:
Hsero_0146
(gbd)
HSZ:
ACP92_00725
HHT:
F506_21500
HRB:
Hrubri_0160
(gbd)
HEE:
hmeg3_22690
HHF:
E2K99_00985
HFR:
G5S34_00730
RGE:
RGE_26150
RBN:
RBXJA2T_08555
RDP:
RD2015_3162
PKT:
AT984_08415
MIU:
ABE85_10710
AON:
DEH84_09325
XYK:
GT347_24120
PBH:
AAW51_2848
URU:
DSM104443_03117
(dhaT_2)
ACOM:
CEW83_15610
DWD:
DSCW_05760
MXA:
MXAN_5629
MSD:
MYSTI_06220
MYM:
A176_001289
MFB:
MFUL124B02_32800
CCX:
COCOR_06119
(dhaT)
MFU:
LILAB_35625
MMAS:
MYMAC_005424
SUR:
STAUR_6309
AGE:
AA314_08031
MBD:
MEBOL_001286
CFUS:
CYFUS_007849
MES:
Meso_4502
PMOB:
HG718_08235
ATA:
AWN88_00520
AVI:
Avi_6101
RPUS:
CFBP5875_23470
RHT:
NT26_p10281
KAI:
K32_18230
BRS:
S23_32850
BOP:
AXW83_17025
BOS:
BSY19_3748
BVV:
BHK69_26655
BOI:
BLM15_10485
BOF:
FQV39_27025
BAPI:
BBC0122_006250
SNO:
Snov_3495
STAR:
G3545_21755
MET:
M446_3465
MNO:
Mnod_0063
MAQU:
Maq22A_1p34110
(eutG)
Maq22A_c07255
(eutG)
MEE:
DA075_08275
MTEA:
DK419_06010
CHEL:
AL346_05120
AL346_06850
AL346_16010
CDQ:
BOQ54_00090
PHL:
KKY_2679
AUA:
M673_00870
AALA:
IGS74_10630
BRN:
D1F64_18695
PSIN:
CAK95_05960
CAK95_11375
RBM:
TEF_16385
TEF_19965
TSV:
DSM104635_00837
(gbsB)
CBOT:
ATE48_05940
PYE:
A6J80_20645
KVL:
KVU_0808
(gbd)
PSF:
PSE_2341
(garR)
CID:
P73_4768
PPHR:
APZ00_11925
APZ00_16710
LAP:
ACP90_24770
LAGG:
B0E33_08230
LABT:
FIU93_02600
(dhaT1)
RID:
RIdsm_01292
(hgd_4)
SAGU:
CDO87_05835
PPRU:
FDP22_20395
HDH:
G5B40_10300
HNE:
HNE_0174
(gbd)
HBC:
AEM38_02135
NOV:
TQ38_027345
NOT:
C7W88_20575
NOG:
GKE62_14000
SPKC:
KC8_02205
SPHB:
EP837_03228
SAMI:
SAMIE_1033770
SHUM:
STHU_13550
STHU_22030
SVC:
STVA_09960
STVA_25540
(garR)
ABS:
AZOBR_p340215
AOZ:
HUE56_26230
HTQ:
FRZ44_48020
(yihU)
HADH:
FRZ61_10700
FRZ61_45740
PHR:
C6569_16040
C6569_18140
PSTG:
E8M01_11950
LNG:
BSQ50_05330
CAC:
CA_C1574
CAE:
SMB_G1599
(4hbD)
CAY:
CEA_G1589
CPE:
CPE0539
CPF:
CPF_0518
CPR:
CPR_0507
CBE:
Cbei_4933
CBZ:
Cbs_4933
CKL:
CKL_3014
(4hbD)
CKR:
CKR_2662
CLJ:
CLJU_c38930
(4hbD)
CSR:
Cspa_c29410
CPAS:
Clopa_4032
Clopa_4274
CPAT:
CLPA_c06290
CLPA_c39010
CPAE:
CPAST_c06290
CPAST_c39010
CAH:
CAETHG_1741
CSQ:
CSCA_3619
CBUT:
ATN24_07925
CTYK:
CTK_C07610
(4hbD)
CEU:
A7L45_11955
CDRK:
B9W14_01605
CDY:
F3K33_25345
CFER:
D4Z93_11460
CRS:
FQB35_09320
FPLA:
A4U99_06825
A4U99_13645
A4U99_15805
A4U99_16840
RUJ:
E5Z56_10345
CEW:
EKH84_04070
LACY:
A4V08_31370
ARF:
AR1Y2_2848
ACAC:
EYQ97_04065
CDF:
CD630_23380
(4hbD)
PDC:
CDIF630_02577
(gbd)
CDC:
CD196_2181
(abfH)
CDL:
CDR20291_2227
(abfH)
PDF:
CD630DERM_23380
(4hbD)
ROC:
HF520_04655
PHX:
KGNDJEFE_01613
(mdh)
TFR:
BR63_10040
AWO:
Awo_c17320
OBJ:
EIO64_02860
CMIU:
B1H56_01420
AMIJ:
EQM06_05015
AMIC:
Ami3637_13480
SPOA:
EQM13_06730
EQM13_09885
MED:
MELS_0336
SRI:
SELR_pSRC102430
ERL:
AOC36_08265
AARG:
Aargi30884_11180
ABSI:
A9CBEGH2_12320
CIU:
G4D55_07405
G4D55_14830
EBM:
SG0102_24860
(4hbD)
ERB:
A4V01_08655
A4V01_17925
LMOI:
VV02_02230
NAL:
B005_2696
B005_3092
SESP:
BN6_54060
BDE:
BDP_2141
(adh2)
BDN:
BBDE_2011
BTP:
D805_1109
GVG:
HMPREF0421_21009
(4hbD)
GVA:
HMPREF0424_0561
GVH:
HMPREF9231_0570
MBF:
BHV42_01460
IPA:
Isop_0941
SACI:
Sinac_0778
PBOR:
BSF38_02758
(adhB)
AGV:
OJF2_08320
(dhaT_1)
TRM:
JO41_12040
TRZ:
GWP43_07800
FNT:
HMPREF0405_01108
FNF:
BSQ88_08650
IPO:
Ilyop_2598
CPOR:
BED41_04035
PGI:
PG_0689
(4hbD)
PGN:
PGN_0724
PGT:
PGTDC60_1814
(4hbD)
PAH:
Poras_0444
PCRE:
NCTC12858_01804
(adhB)
PCAG:
NCTC12856_01247
(eutG)
TFO:
BFO_1487
OSP:
Odosp_2059
BUY:
D8S85_11135
» show all
Taxonomy
Reference
1 [PMID:
14427301
]
Authors
NIRENBERG MW, JAKOBY WB.
Title
Enzymatic utilization of gamma-hydroxybutyric acid.
Journal
J Biol Chem 235:954-60 (1960)
Other DBs
ExplorEnz - The Enzyme Database:
1.1.1.61
IUBMB Enzyme Nomenclature:
1.1.1.61
ExPASy - ENZYME nomenclature database:
1.1.1.61
BRENDA, the Enzyme Database:
1.1.1.61
CAS:
9028-60-8
LinkDB
All DBs
DBGET
integrated database retrieval system