| Entry |
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| Name |
D-2-hydroxyacid dehydrogenase (quinone);
(R)-2-hydroxy acid dehydrogenase;
(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase;
D-lactate dehydrogenase (ambiguous)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
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| Sysname |
(R)-2-hydroxyacid:quinone oxidoreductase
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| Reaction(IUBMB) |
(R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol [RN: R10625]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors.
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| History |
EC 1.1.5.10 created 2014
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| Reference |
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| Authors |
TUBBS PK, GREVILLE GD. |
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| Title |
Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria. |
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| Journal |
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| Reference |
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| Authors |
TUBBS PK, GREVILLE GD |
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| Title |
The oxidation of D-alpha-hydroxy acids in animal tissues. |
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| Journal |
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| Reference |
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| Authors |
Cammack R |
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| Title |
Assay, purification and properties of mammalian D-2-hydroxy acid dehydrogenase. |
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| Journal |
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| Reference |
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| Authors |
Cammack R |
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| Title |
D-2-hydroxy acid dehydrogenase from animal tissue. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.5.10 |
| ExPASy - ENZYME nomenclature database: | 1.1.5.10 |
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| LinkDB |
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