KEGG ENZYME: 1.1.5.10

ENZYME: 1.1.5.10

Entry

EC 1.1.5.10 Enzyme

Name

D-2-hydroxyacid dehydrogenase (quinone);
(R)-2-hydroxy acid dehydrogenase;
(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase;
D-lactate dehydrogenase (ambiguous)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor

Sysname

(R)-2-hydroxyacid:quinone oxidoreductase

Reaction(IUBMB)

(R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol [RN:R10625]

Reaction(KEGG)

R10625

Substrate

(R)-2-hydroxyacid [CPD:C02489];
quinone [CPD:C15602]

Product

2-oxo acid [CPD:C00161];
quinol [CPD:C15603]

Comment

The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors.

History

EC 1.1.5.10 created 2014

Reference

1 [PMID:13839714]

Authors

TUBBS PK, GREVILLE GD.

Title

Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria.

Journal

Biochim Biophys Acta 34:290-1 (1959)
DOI:10.1016/0006-3002(59)90276-8

Reference

2 [PMID:13922962]

Authors

TUBBS PK, GREVILLE GD

Title

The oxidation of D-alpha-hydroxy acids in animal tissues.

Journal

Biochem J 81:104-14 (1961)
DOI:10.1042/bj0810104

Reference

3 [PMID:5359443]

Authors

Cammack R

Title

Assay, purification and properties of mammalian D-2-hydroxy acid dehydrogenase.

Journal

Biochem J 115:55-64 (1969)
DOI:10.1042/bj1150055

Reference

4 [PMID:236454]

Authors

Cammack R

Title

D-2-hydroxy acid dehydrogenase from animal tissue.

Journal

Methods Enzymol 41:323-9 (1975)
DOI:10.1016/S0076-6879(75)41073-4

Other DBs

ExplorEnz - The Enzyme Database:

1.1.5.10

IUBMB Enzyme Nomenclature:

1.1.5.10

ExPASy - ENZYME nomenclature database:

1.1.5.10

BRENDA, the Enzyme Database:

1.1.5.10

LinkDB

DBGET integrated database retrieval system