EC                Enzyme                                 

lipoyl-dependent peroxiredoxin;
ahpC (gene name);
ahpD (gene name)
Acting on a peroxide as acceptor;
lipoyl:hydroperoxide oxidoreductase
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + ROOH = a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ROH [RN:R12602]
R12602 > R12603
[lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine [CPD:C16832];
ROOH [CPD:C15498]
[lipoyl-carrier protein]-N6-lipoyl-L-lysine;
H2O [CPD:C00001];
ROH [CPD:C01335]
Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [2]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Two types of lipoyl-dependent peroxiredoxins have been reported from bacteria. One type is the AhpC/AhpD system, originally described from Mycobacterium tuberculosis. In that system, AhpC catalyses reduction of the substrate, resulting in an intramolecular disulfide. AhpD then forms an intermolecular disulfide crosslink with AhpC, reducing it back to active state. AhpD is reduced in turn by lipoylated proteins. The second type, which has been characterized in Xylella fastidiosa, consists of only one type of subunit, which interacts directly with lipoylated proteins.
EC created 1983 as EC, part transferred 2020 to EC
K04063  lipoyl-dependent peroxiredoxin
K04756  lipoyl-dependent peroxiredoxin subunit D
K24126  lipoyl-dependent peroxiredoxin subunit C
OTW: 112242618
DSR: 110189174
DPA: 109545767
ZJU: 107408917 107408918
ECO: b1482(osmC)
ECJ: JW1477(osmC)
ECD: ECDH10B_1613(osmC)
EBW: BWG_1303(osmC)
ECOK: ECMDS42_1194(osmC)
ECE: Z2228(osmC)
ECS: ECs2086
ECF: ECH74115_2094(osmC)
ETW: ECSP_1967(osmC)
EOI: ECO111_1872(osmC)
EOJ: ECO26_2080(osmC)
EOH: ECO103_1611(osmC)
ECOO: ECRM13514_1919(osmC)
ECOH: ECRM13516_1839(osmC)
ESL: O3K_13085
ESO: O3O_12545
ESM: O3M_13050
ECK: EC55989_1614(osmC)
ECG: E2348C_1616(osmC)
EOK: G2583_1845(osmC)
ELH: ETEC_1552
ECW: EcE24377A_1664(osmC)
ECP: ECP_1484
ENA: ECNA114_3658(osmC)
ECOS: EC958_1750(osmC)
ECV: APECO1_617(osmC)
ECX: EcHS_A1567(osmC)
ECM: EcSMS35_1691(osmC)
ECY: ECSE_1572
ECR: ECIAI1_1485(osmC)
ECQ: ECED1_1634(osmC)
EUM: ECUMN_1736(osmC)
ECT: ECIAI39_1746(osmC)
EOC: CE10_1672(osmC)
EBR: ECB_01440(osmC)
EBL: ECD_01440(osmC)
EBE: B21_01452(osmC)
EBD: ECBD_2157
ECI: UTI89_C1701(osmC)
EIH: ECOK1_1642(osmC)
ECZ: ECS88_1576(osmC)
ECC: c1916(osmC)
ELO: EC042_1614(osmC)
ESE: ECSF_1397
EAB: ECABU_c17210(osmC)
EDJ: ECDH1ME8569_1425(osmC)
ELW: ECW_m1610(osmC)
ELL: WFL_07880(osmC)
ELC: i14_1739(osmC)
ELD: i02_1739(osmC)
ELP: P12B_c1647(osmC)
ELF: LF82_1577(osmC)
ECOI: ECOPMV1_01622(osmC)
ECOJ: P423_08240
EFE: EFER_1499(osmC)
EAL: EAKF1_ch0018c(osmC)
ESZ: FEM44_22505(osmC)
STY: STY1497(osmC)
STT: t1478(osmC)
STM: STM1563(osmC)
SEO: STM14_1886(osmC)
SEY: SL1344_1493(osmC)
SEJ: STMUK_1532(osmC)
SEB: STM474_1575(osmC)
SEF: UMN798_1637(osmC)
SENR: STMDT2_14861(osmC)
SEND: DT104_15331(osmC)
SENI: CY43_07980
SPT: SPA1305(osmC)
SEI: SPC_2175(osmC)
SEC: SCH_1564(osmC)
SHB: SU5_02176
SENS: Q786_07410
SED: SeD_A1780
SEG: SG1564(osmC)
SEL: SPUL_1371(osmC)
SEGA: SPUCDC_1371(osmC)
SET: SEN1492(osmC)
SENA: AU38_07705
SENO: AU37_07705
SENV: AU39_07715
SENQ: AU40_08650
SENL: IY59_07900
SEEP: I137_06365
SENB: BN855_16080(osmC)
SENE: IA1_07735
SBG: SBG_1385(osmC)
SBZ: A464_1585
SFL: SF1743(osmC)
SFX: S1876(osmC)
SFV: SFV_1739(osmC)
SFE: SFxv_1951(osmC)
SFN: SFy_2496
SFS: SFyv_2552
SFT: NCTC1_01889(osmC)
SSN: SSON_1642(osmC)
SBO: SBO_1575(osmC)
SBC: SbBS512_E1745(osmC)
SDY: SDY_1610(osmC)
KPN: KPN_01831
KPU: KP1_2891
KPP: A79E_2400
KPR: KPR_2397(osmC)
KPJ: N559_2460
KPX: PMK1_04174(osmC)
KPNU: LI86_12250
KPNK: BN49_2930(osmC)
KVA: Kvar_2473
KPE: KPK_2527(osmC)
KOX: KOX_20140
KOE: A225_2899
EAE: EAE_19705
EAR: CCG29942
CRO: ROD_15531(osmC)
CKO: CKO_01519
CAMA: F384_07150
RTG: NCTC13098_03779(osmC)
REE: electrica_02578(osmC)
CLAP: NCTC11466_02675(ohrB_1) NCTC11466_03957(ohrB_2) NCTC11466_04706(ohrB_3)
KIE: NCTC12125_00181(osmC)
AHN: NCTC12129_02334(osmC)
EBF: D782_2146
PSTS: E05_32040 E05_42460(osmC)
YEN: YE4091
YEY: Y11_31071
YEW: CH47_3638
YET: CH48_1539
YAL: AT01_2594
YFR: AW19_3362
YIN: CH53_1652
YKR: CH54_2428
YRO: CH64_2489
SMAR: SM39_4370
SPE: Spro_0130
SPLY: Q5A_000530(ohrB)
SMAF: D781_0095
SERF: L085_05070
SFJ: SAMEA4384070_0095(ohrB)
SOF: NCTC11214_01876(ohrB)
ECA: ECA2221(osmC) ECA3167(ohr)
PATO: GZ59_23450(osmC) GZ59_31770
PEC: W5S_1235
DDQ: DDI_3720
EAM: EAMY_1068(osmC) EAMY_3618(ohr)
EAY: EAM_1076(osmC) EAM_3397
ETA: ETA_23950(osmC) ETA_34010(ohr)
EPY: EpC_25320(osmC) EpC_36120(ohr)
EPR: EPYR_02745(osmC) EPYR_03888(ohr)
EBI: EbC_20240(osmC) EbC_44150
ERJ: EJP617_10890(ohr) EJP617_21950(osmC)
PAM: PANA_0119 PANA_0926(osmC)
PLF: PANA5342_3382(osmC) PANA5342_4308(ohr)
PAJ: PAJ_0257(osmC)
PVA: Pvag_0302(osmC) Pvag_3344(ohr)
MINT: C7M51_02457(osmC) C7M51_03656(ohrB)
MTHI: C7M52_00397(osmC) C7M52_03368(ohrB)
TPTY: NCTC11468_00998(osmC)
XPO: XPG1_0109
HPIT: NCTC13334_00133(ohrB)
MSU: MS2101(osmC)
MHQ: D650_8170
MHAT: B824_18080
MHX: MHH_c26530(ohr)
MHAE: F382_04020
MHAM: J450_03050
MHAO: J451_04260
MHAL: N220_10120
MHAQ: WC39_04085
MHAY: VK67_04085
MVR: X781_6160
ASU: Asuc_1648
BTO: WQG_670
BTRE: F542_20900
BTRH: F543_23180
BTRA: F544_690
XFA: XF_1827
XFT: PD_1040(ohr)
XCC: XCC0264(ohr) XCC2745(osmC)
XCV: XCV0290(ohr) XCV3060
XAX: XACM_0268(ohr) XACM_2847(osmC)
XAC: XAC0282(ohr) XAC2915(osmC)
XCI: XCAW_00682(osmC) XCAW_03193(osmC)
XOM: XOO1312(XOO1312) XOO4195(XOO4195)
XOO: XOO1428(osmC) XOO4456(ohr)
XOP: PXO_02004(osmC) PXO_03888(ohr)
XOR: XOC_1499 XOC_4608(ohr)
XAL: XALC_0160(ohr)
XPH: XppCFBP6546_10470(XppCFBP6546P_10470) XppCFBP6546_21335(XppCFBP6546P_21335)
SML: Smlt0269(ohr) Smlt1165(osmC) Smlt2507
SMZ: SMD_0234(ohr) SMD_1086(osmC)
SACZ: AOT14_01770(ohr) AOT14_26900(osmC)
LEM: LEN_0628(ohrB) LEN_1269(ahpC) LEN_1270(ahpD) LEN_3650(osmC)
DKO: I596_1981
RBD: ALSL_1232
VCH: VCA1006
VCS: MS6_A1038
VCI: O3Y_18208
VVU: VV2_0577
VVY: VVA1125
VPA: VPA1681
VAG: N646_3409
VSP: VS_II1311
VTA: A2170
VFI: VF_A0335
PPR: PBPRB1177(BRA0885)
PAE: PA0059(osmC) PA2850(ohr)
PAU: PA14_00710(osmC) PA14_27220(ohr)
PAP: PSPA7_0059(osmC) PSPA7_2305(ohr)
PAG: PLES_00601(osmC) PLES_22141(ohr)
PAF: PAM18_0060(osmC) PAM18_2113(ohr)
PNC: NCGM2_0063(osmC) NCGM2_3959(ohr)
PAEB: NCGM1900_0059(osmC) NCGM1900_3463(ohr)
PAEU: BN889_00099(osmC) BN889_03178(ohr)
PPSE: BN5_2297(ohr)
PCQ: PcP3B5_20360(ohrB_1) PcP3B5_30460(ohrB_2) PcP3B5_31540(ohrB_3) PcP3B5_31620(ohrB_4) PcP3B5_33410(ohrB_5)
PPU: PP_0089(osmC) PP_1859(ohr)
PPX: T1E_0914(osmC) T1E_5087(ohr)
PPUN: PP4_00810(osmC) PP4_39240(ohr)
PST: PSPTO_0152(osmC) PSPTO_1767(ohr)
PSP: PSPPH_0042(osmC) PSPPH_3646(ohr)
PVD: CFBP1590_0118(osmC) CFBP1590__1640(ohr)
PFL: PFL_0043(osmC) PFL_4263(ohr)
PPRC: PFLCHA0_c00440(osmC) PFLCHA0_c43290(ohr)
PPRO: PPC_0047 PPC_4364(ohr_1)
PFS: PFLU_0042(osmC) PFLU_1716(ohrB)
PFC: PflA506_0041(osmC) PflA506_1763(ohr)
PEN: PSEEN1563(ohr)
PSA: PST_0169(ohr) PST_0265(osmC)
PSR: PSTAA_0232(ohr) PSTAA_0315(osmC)
PSEC: CCOS191_0045(osmC) CCOS191_3811(ohr)
PSOS: POS17_0048 POS17_4337(ohr_1)
AVN: Avin_01800(osmC) Avin_15290(ohr)
AVL: AvCA_01800(osmC) AvCA_15290(ohr)
AVD: AvCA6_01800(osmC) AvCA6_15290(ohr)
PAR: Psyc_0379(ohrA)
PALI: A3K91_0480
PSYC: DABAL43B_0482(ohrA)
PSYA: AOT82_1324
ACB: A1S_0617
ABY: ABAYE3144(ohr)
ABN: AB57_0720
ABB: ABBFA_02919(ohrB)
ABX: ABK1_0657
ABH: M3Q_865
ABAD: ABD1_06230(ohr)
ABAZ: P795_14335
ABAU: IX87_17585
ABAA: IX88_05290
ACC: BDGL_003524(ohr)
ACI: ACIAD3023(ohr)
AGU: AS4_37540
MCT: MCR_1743
MCS: DR90_216
MCAT: MC25239_01658(ohrB)
MCUN: NCTC10297_01388(ohrB_1) NCTC10297_01729(ohrB_2)
SON: SO_0976(ohrA)
SDN: Sden_0377
SFR: Sfri_3597
SBL: Sbal_0865
SLO: Shew_1244
SSE: Ssed_1386
SWD: Swoo_1516
SWP: swp_4320
SVO: SVI_1334(ohr)
SPSW: Sps_03881
ILO: IL0080 IL2550(osmC) IL2575(ahpD) IL2576
CPS: CPS_3330(ohr)
PHA: PSHAa2202(osmC) PSHAb0180(osmC)
PSM: PSM_A0939(osmC) PSM_B0193
PART: PARC_a2936(osmC) PARC_b0221
PSEN: PNC201_08100(ohrB)
PAGA: PAGA_a2801(osmC) PAGA_b0281
MAD: HP15_2791
MBS: MRBBS_3765(ohr)
GNI: GNIT_0183(osmC)
GPS: C427_1166
PIN: Ping_2314
FBL: Fbal_3056
MVS: MVIS_1339
MYA: MORIYA_1695(ohr)
MICC: AUP74_00621(ohrB)
MICT: FIU95_20030(ohrB)
CBU: CBU_1477 CBU_1478(ahpD)
CBD: CBUD_0521(ahpC) CBUD_0522(ahpD)
CBG: CbuG_0528(ahpD) CbuG_0531(ahpC)
CBC: CbuK_1708(ahpC.2) CbuK_1709(ahpD.5)
RVI: RVIR1_08410(ahpD) RVIR1_08420(ahpC) RVIR1_13810(ahpC)
LPH: LPV_2622 LPV_2623(ahpC)
LPM: LP6_1954(osmC1) LP6_2378(ahpD) LP6_2379
LPA: lpa_02882(osmC) lpa_03364 lpa_03365(ahpC)
LFA: LFA_0039 LFA_3249(ahpD) LFA_3250(ahpC)
LHA: LHA_0991(osmC) LHA_2374(ahpD) LHA_2375(ahpC)
LCD: clem_03605 clem_03610(ahpD) clem_10170(osmC)
LLG: 44548918_02107(ahpD) 44548918_02108(ahpC_1)
LJR: NCTC11533_02136(ahpC_1)
TMC: LMI_2507(ahpD) LMI_2508(ahpC)
TEE: Tel_16185
GAI: IMCC3135_03825(ohrA)
HCH: HCH_01357
CSA: Csal_1158
HEL: HELO_3174(osmC)
HCO: LOKO_02405(osmC)
HBE: BEI_2628(osmC)
HSR: HSBAA_16060(osmC)
ADI: B5T_01686(ohr)
AXE: P40_07995
KGE: TQ33_1155
AHA: AHA_3610
ASA: ASA_3572(osmC)
CHJ: NCTC10426_00614(ohrB)
CVI: CV_0209(ohr2) CV_2493(ohr1)
RSO: RSc1645(ahpD) RSc1646(ahpC2) RSp1107(ohr)
REH: H16_A1459(h16_A1459) H16_A1460(h16_A1460) H16_B0157(ohr) H16_B1801(h16_B1801) H16_B1985(h16_B1985)
RME: Rmet_1950(ahpC) Rmet_1951(ahpD) Rmet_3618(ohrB)
CGD: CR3_1547(ahpC) CR3_1548(ahpD) CR3_3253(osmC) CR3_3664(osmC) CR3_4260(osmC) CR3_4362(osmC)
BMA: BMA1487 BMA1488(ahpD) BMAA0303(ohr)
CABA: SBC2_16680(ahpD) SBC2_16690 SBC2_53700(ohrB_1) SBC2_56740(ohrB_2) SBC2_64580(osmC)
BPE: BP3551(ahpD) BP3552(ahpC)
BPC: BPTD_3498(ahpD) BPTD_3499(ahpC)
BPER: BN118_2707(ahpC) BN118_2708(ahpD)
BPET: B1917_3331(ahpD) B1917_3332(ahpC)
BPEU: Q425_5510(ahpC) Q425_5520(ahpD)
BPAR: BN117_2037(osmC) BN117_3325(ahpC) BN117_3326(ahpD)
BPA: BPP1969(osmC) BPP3361(ahpC) BPP3362(ahpD)
BBH: BN112_1360(osmC) BN112_4602(ahpD) BN112_4603(ahpC)
BBR: BB2157(osmC) BB3812(ahpC) BB3813(ahpD)
BBM: BN115_2879(osmC) BN115_3484(ahpC) BN115_3485(ahpD)
BBX: BBS798_2056(osmC) BBS798_3592(ahpC) BBS798_3593(ahpD)
BPT: Bpet1697(ahpD) Bpet1698(ahpC) Bpet3187
BAV: BAV1063(ahpD) BAV1064(ahpC) BAV2446(ohr)
TEA: KUI_0463(ahpD) KUI_0464(ahpC)
TEG: KUK_0090(ahpC) KUK_0091(ahpD)
TAT: KUM_0530(ahpD) KUM_0531(ahpC)
AMIM: MIM_c21060(ohr1) MIM_c24360(ahpC) MIM_c24370 MIM_c34840(ohr2)
BPSI: IX83_07695
RFR: Rfer_0574
POL: Bpro_0622
CTES: O987_25635
RTA: Rta_34670(ohr)
HPSE: HPF_03220(ohrB)
HAR: HEAR1620(osmC)
MMS: mma_2925(ohr1) mma_3332(ohr2)
JAG: GJA_3800(osmC) GJA_463(osmC) GJA_5185(ohr) GJA_5342(ohr)
HSE: Hsero_3060(osmC)
HRB: Hrubri_3077(osmC)
CFU: CFU_0922(ohr) CFU_2569(osmC)
OFO: BRW83_0329(osmC)
LCH: Lcho_2080
RGE: RGE_23990(ohr)
MEH: M301_1810
DSU: Dsui_2173
DAR: Daro_2067
AZO: azo2405(ohr)
AOA: dqs_2549
TPJ: TPPAVE_124(ahpC)
KCI: CKCE_0129(ahpC)
KCT: CDEE_0789
KBL: CKBE_00601(ahpC)
KBT: BCUE_0758
KDE: CDSE_0775
KGA: ST1E_0858
KON: CONE_0740
SSDC: SSDC_01160(ahpC)
PCA: Pcar_2843(osmC)
DML: Dmul_14540(osmC)
DWD: DSCW_56180(osmC)
MXA: MXAN_0655(ohr) MXAN_1563 MXAN_1564(ahpC)
CCX: COCOR_00561(ohr) COCOR_01575(ahpD) COCOR_01576(ahpC) COCOR_05206(osmC)
SCL: sce0181
CCRO: CMC5_052900(ohr)
HOH: Hoch_1642
MES: Meso_3240
AMIH: CO731_01115(osmC)
PLA: Plav_2250
ATU: Atu0847(ohr)
RLE: RL1302 RL2737(ohr1) RL4226(osmC)
RIR: BN877_I0831(ohr1) BN877_II1904(ohr2)
RHL: LPU83_1140(ohr1) LPU83_3305(ohr3) LPU83_3724(osmC)
RHT: NT26_0773(ohr)
BMF: BAB2_0351(ohr) BAB2_0531(ahpC) BAB2_0532
BMB: BruAb2_0347(ohr) BruAb2_0522(ahpC) BruAb2_0523(ahpD)
BMS: BRA0707(ahpD) BRA0708(ahpC) BRA0885(ohr)
BSF: BSS2_II0672(ahpD) BSS2_II0673(ahpC) BSS2_II0838(ohr)
BOV: BOV_A0664(ahpC) BOV_A0829(ohr)
BOL: BCOUA_II0707(ahpD) BCOUA_II0708(ahpC) BCOUA_II0885(ohr)
BMR: BMI_II701(ahpD) BMI_II702(ahpC) BMI_II879(ohr)
BPP: BPI_II761(ahpD) BPI_II762(ahpC) BPI_II941(ohr)
BJA: bll0735 bll1776(ahpD) bll1777(ahpC) bll6262(osmC) blr1196(ohr)
BRO: BRAD285_1855(ahpD) BRAD285_1856(AhpC) BRAD285_7369(ohr)
RPA: RPA0829(ohr) RPA4101 RPA4194(osmC)
RPD: RPD_1401
NWI: Nwi_0432
NHA: Nham_0530
VGO: GJW-30_1_01174(ohrB)
MEA: Mex_1p2305(osmC) Mex_1p2453(ohr)
MDI: METDI3086(osmC) METDI3216(ohr)
MOR: MOC_3215
MAQU: Maq22A_c08675(osmC) Maq22A_c15370(osmC)
HDN: Hden_3403
HMC: HYPMC_4723(ohr)
PHL: KKY_3385
BLAG: BLTE_32710
PLEO: OHA_1_02064(ohrB) OHA_1_02969(ahpD) OHA_1_02970(ahpC)
MMED: Mame_03823(ohrB)
MCG: GL4_0102
HDI: HDIA_0326(ohrB) HDIA_4392(ahpD1) HDIA_4393(ahpC)
PZU: PHZ_c0264
SIL: SPO0254(ohr)
RSP: RSP_0585(osmC)
KVL: KVU_2479(osmC)
KVU: EIO_0286
PSF: PSE_0180(tdx) PSE_0181(ahpD) PSE_4466
PGA: PGA1_c34100(ohr)
PGL: PGA2_c32310(ohr)
PGD: Gal_03477
PHP: PhaeoP97_03311(ohr)
PPIC: PhaeoP14_03217(ohr)
CID: P73_3424
MALG: MALG_02340
LABT: FIU93_18800(ohrB)
SPSE: SULPSESMR1_01845(osmC)
ROH: FIU89_06640(ohrB)
AHT: ANTHELSMS3_02075(ohrB)
MARU: FIU81_08115(osmC)
ROT: FIV09_05110(osmC)
MALU: KU6B_42480
HNE: HNE_2388(ohr) HNE_3034 HNE_3035(ahpC)
HBA: Hbal_0034
ZMC: A265_00594(ohrB) A265_01431(ahpC)
ZMR: A254_00594(ohrB) A254_01430(ahpC)
SPHP: LH20_18375
SMAZ: LH19_22750
SGI: SGRAN_3924(osmC)
SPHU: SPPYR_1069 SPPYR_3798(osmC)
SPHI: TS85_03095
SPMI: K663_04465
SPHR: BSY17_2061
SPHT: K426_15475
SMIC: SmB9_03630(osmC_1) SmB9_31380(osmC_2)
ELI: ELI_14070
AAY: WYH_01688(ohrA)
ANH: A6F65_00258(osmC)
GOX: GOX1992
GOH: B932_3533
GOY: GLS_c21050(osmC)
ACR: Acry_0819
AMV: ACMV_10940(ohr)
GDI: GDI0575(ahpD) GDI0576 GDI3229(osmC)
KSC: CD178_02339(osmC)
APK: APA386B_1694(ahpC) APA386B_1695(ahpD) APA386B_2674(osmC)
ASZ: ASN_2219(ahpC) ASN_2221(ahpD) ASN_3705(osmC)
SHUM: STHU_23640(osmC) STHU_42110(ahpD) STHU_42120
SVC: STVA_31990(osmC) STVA_45850(ahpD) STVA_45860
RCE: RC1_0439(ahpC) RC1_0440(ahpD) RC1_0833 RC1_2171(ohr)
MAG: amb3303
AZL: AZL_010450(osmC)
ALI: AZOLI_0918(ohr) AZOLI_p40271(osmC)
ABS: AZOBR_p220076(ohr) AZOBR_p270135(osmC)
TMO: TMO_1569 TMO_2424(osmC) TMO_2498(ahpC) TMO_2499(ahpD)
MAI: MICA_507(ahpC) MICA_508(ahpD) MICA_700(ohr)
BBA: Bd1436
BBAT: Bdt_1418
BBAC: EP01_03440
BSU: BSU13140(ohrA) BSU13160(ohrB)
BSR: I33_1477(ohrA) I33_1479(ohrB)
BSH: BSU6051_13140(ohrA) BSU6051_13160(ohrB)
BSUT: BSUB_01431(ohrA) BSUB_01433(ohrB)
BSUL: BSUA_01431(ohrA) BSUA_01433(ohrB)
BSS: BSUW23_06730(ohrA) BSUW23_06740(ohrB)
BST: GYO_1633(ohrA) GYO_1635(ohrB)
BSO: BSNT_07800(yklA) BSNT_07802(ykzA)
BSQ: B657_13140(ohrA) B657_13160(ohrB)
BSX: C663_1352(ohrA) C663_1354(ohrB)
BLI: BL03731(ohrB) BL05119(ohrA)
BLD: BLi01414(ohrA) BLi01416(ohrB)
BLH: BaLi_c15560(ohrA) BaLi_c15580(ohrB)
BAQ: BACAU_0455(ohrA1) BACAU_1272(ohrA3) BACAU_1274(ohrB)
BYA: BANAU_1231(ohrA) BANAU_1233(ohrB)
BAML: BAM5036_1230(ohrA) BAM5036_1232(ohrB)
BAMA: RBAU_1273(ohrA) RBAU_1275(ohrB)
BAMN: BASU_1252(ohrA) BASU_1254(ohrB)
BAMB: BAPNAU_2469(ohrB) BAPNAU_2471(ohrA) BAPNAU_3235(ymaD3)
BAMY: V529_12430(ohrA) V529_12450(ohrB)
BMP: NG74_01344(ohrA) NG74_01346(ohrB) NG74_03206
BAO: BAMF_1398(ohrA) BAMF_1400(ohrB)
BQL: LL3_00480(ohrB) LL3_01413(ohrA) LL3_01415(ohrB)
BQY: MUS_1387(ohrA) MUS_1389(ohrB)
BAN: BA_4700
BAR: GBAA_4700
BAT: BAS4365
BAI: BAA_4718
BANT: A16_46950
BANR: A16R_47580
BANV: DJ46_3374
BCE: BC4475
BCA: BCE_4559
BCZ: BCE33L4212(ohrA)
BCQ: BCQ_4255(ohrA)
BCX: BCA_4580
BAL: BACI_c44560(ohrA)
BNC: BCN_4378
BCF: bcf_22350
BCER: BCK_12855
BTK: BT9727_4201(ohrA)
BTL: BALH_4061(ohrA)
BTT: HD73_4775
BTHI: BTK_23535
BTM: MC28_3760
BTG: BTB_c46050(ohrA)
BTW: BF38_220
BWW: bwei_0413(ohrB)
BMYO: BG05_1561
BMYC: DJ92_1565
BMQ: BMQ_0326(ohrA) BMQ_2275(ohrB)
BMD: BMD_0327(ohrA) BMD_2231(ohrB)
BMEG: BG04_2617(ohrB) BG04_4646(ohrB)
BACL: BS34A_14550(ohrA) BS34A_14570(ohrB)
BEO: BEH_16035
BGY: BGLY_1405(ohrA) BGLY_1408(ohrB)
BBEV: BBEV_1611(ohrB)
BCL: ABC1785(ohrB)
BPF: BpOF4_14780(ohrB)
BKW: BkAM31D_06345(ohrB)
GKA: GK1863
AXL: AXY_03050(ohr)
LSP: Bsph_3209(ohrA)
HHD: HBHAL_1343(ohrB)
HLI: HLI_09765
VPN: A21D_03709(ohrB)
BSE: Bsel_1974
SAU: SA0755
SAV: SAV0828
SAW: SAHV_0824
SAM: MW0781
SAS: SAS0768
SAR: SAR0859
SAX: USA300HOU_0835(osmC)
SAE: NWMN_0771
SAD: SAAV_0774
SUJ: SAA6159_00759(osmC)
SUK: SAA6008_00818(osmC)
SUC: ECTR2_754
SUZ: MS7_0854(ohrB)
SAUA: SAAG_01227
SAUS: SA40_0741
SAUU: SA957_0756
SAUG: SA268_0755
SAUF: X998_0851
SAB: SAB0759c
SAUB: C248_0896
SAUM: BN843_8030
SAUC: CA347_821(ohrB)
SAUR: SABB_00851
SAUI: AZ30_04170
SAUD: CH52_01745
SAMS: NI36_04085
SHA: SH2056
SHH: ShL2_01913(osmC)
SDT: SPSE_1939
SSCH: LH95_09285
SSCZ: RN70_10060
MCL: MCCL_0051
MCAK: MCCS_01140(ohrA)
LMO: lmo2199
LMOC: LMOSLCC5850_2267(ohrB)
LMOE: BN418_2649
LMOB: BN419_2653
LMOW: AX10_05290
LMOQ: LM6179_2978(ohrA)
LMR: LMR479A_2312(ohrA)
LMOM: IJ09_13915
LMP: MUO_11290
LMOL: LMOL312_2218(ohrB)
LMOX: AX24_08905
LMQ: LMM7_2301(osmC)
LML: lmo4a_2260(ohrB)
LMS: LMLG_0854
LMW: LMOSLCC2755_2267(ohrB)
LMX: LMOSLCC2372_2267(ohrB)
LMZ: LMOSLCC2482_2265(ohrB)
LMON: LMOSLCC2376_2156(ohrB)
LMOS: LMOSLCC7179_2177(ohrB)
LMOO: LMOSLCC2378_2230(ohrB)
LMOY: LMOSLCC2479_2264(ohrB)
LMOT: LMOSLCC2540_2298(ohrB)
LMOA: LMOATCC19117_2224(ohrB)
LMOK: CQ02_11415
LIN: lin2302
LWE: lwe2216
LSG: lse_2179
LIV: LIV_2186
LGZ: NCTC10812_02182(ohrB)
EAN: Eab7_0510(ohrB) Eab7_1502
BBE: BBR47_57740(ohrB)
PPM: PPSC2_06440(ohrA1) PPSC2_09795(ohrA3) PPSC2_12345(ymaD3)
PPO: PPM_1217(ohrA1) PPM_1871(ohrA3) PPM_2365(ymaD3)
PMW: B2K_24265
PSWU: SY83_09880
SIV: SSIL_0156(ohrA)
LLA: L183902(yfiE) L68759(osmC)
LLK: LLKF_0043(osmC) LLKF_0570(yfiE)
LLT: CVCAS_0064(osmC1) CVCAS_0502(yfiE)
LLS: lilo_0041(osmC) lilo_0478(yfiE)
LLM: llmg_0080(osmC)
LLC: LACR_0059
LLR: llh_0275
LLI: uc509_0042(osmC)
LLW: kw2_0055
LLJ: LG36_0044 LG36_0520(yfiE)
LPK: LACPI_1149(ohrA)
SAG: SAG0530
SAN: gbs0575
SAK: SAK_0680
SGC: A964_0564
SAGM: BSA_6170
SAGI: MSA_6320
SAGP: V193_02935
SAGC: DN94_02935
SAGE: EN72_03030
SAGG: EN73_03105
SAGN: W903_0706
LPL: lp_0858
LPJ: JDM1_0715
LPZ: Lp16_0682
LSA: LCA_0552
LBR: LVIS_0709
LCB: LCABL_06980(ohrA)
LFE: LAF_1711
LFF: LBFF_1895
LBH: Lbuc_2121
EFA: EF0453
EFL: EF62_0772(ohr)
EFI: OG1RF_10338(ohr)
EFS: EFS1_0333
EFQ: DR75_2443(ohrB)
ENE: ENT_25360
EMU: EMQU_1453
ESG: EsVE80_20400(yfiE) EsVE80_24470(osmC)
MPS: MPTP_0550
MPX: MPD5_1367
OOE: OEOE_1852
LCI: LCK_01665
LKI: LKI_05995
CSQ: CSCA_0633
ERH: ERH_1349(ohr)
MGE: MG_454
MGU: CM5_02615
MGC: CM9_02670
MGQ: CM3_02790
MGX: CM1_02710
MPN: MPN668(osmC)
MPJ: MPNE_0778
MGA: MGA_1142(osmC)
MGH: MGAH_1142(osmC)
MGF: MGF_4023(osmC)
MGN: HFMG06NCA_2154(osmC)
MGS: HFMG95NCA_2199(osmC)
MGT: HFMG01NYA_2211(osmC)
MGV: HFMG94VAA_2271(osmC)
MGW: HFMG01WIA_2146(osmC)
MGAC: HFMG06CAA_2151(osmC)
MGAN: HFMG08NCA_2155(osmC)
MGNC: HFMG96NCA_2196(osmC)
MGZ: GCW_01635(osmC)
POY: PAM_296
PML: ATP_00240
PAL: PA0087
NZS: SLY_0096
PSOL: S284_03450
ACL: ACL_0040
APAL: BN85413810
AOC: Aocu_14110(osmC)
AAXA: NCTC10138_00935(ohrB)
MFL: Mfl117
MTU: Rv2428(ahpC) Rv2429(ahpD)
MTC: MT2503(ahpC) MT2504(ahpD)
MRA: MRA_2455(ahpC) MRA_2456(ahpD)
MTUR: CFBS_2572(ahpC) CFBS_2573(ahpD)
MTO: MTCTRI2_2472(ahpC) MTCTRI2_2473(ahpD)
MTD: UDA_2428(ahpC) UDA_2429(ahpD)
MTN: ERDMAN_2672(ahpC) ERDMAN_2673(ahpD)
MTUB: MT7199_2460(ahpC) MT7199_2461(ahpD)
MTUT: HKBT1_2564(ahpC) HKBT1_2565(ahpD)
MTUU: HKBT2_2567(ahpC) HKBT2_2568(ahpD)
MTQ: HKBS1_2571(ahpC) HKBS1_2572(ahpD)
MBO: BQ2027_MB2454(ahpC) BQ2027_MB2455(ahpD)
MBB: BCG_2447(ahpC) BCG_2448(ahpD)
MBT: JTY_2441(ahpC) JTY_2442(ahpD)
MBM: BCGMEX_2437(ahpC) BCGMEX_2438(ahpD)
MAF: MAF_24440(ahpC) MAF_24450(ahpD)
MCE: MCAN_24661(ahpC) MCAN_24671(ahpD)
MCQ: BN44_50409(ahpC) BN44_50410(ahpD)
MCV: BN43_40086(ahpC) BN43_40087(ahpD)
MCX: BN42_40377(ahpC) BN42_40378(ahpD)
MCZ: BN45_50807(ahpC) BN45_50808(ahpD)
MLE: ML2042(ahpC)
MLB: MLBr02042(ahpC)
MPA: MAP_1588c(ahpD) MAP_1589c(ahpC)
MAV: MAV_2839 MAV_2840(ahpD)
MUL: MUL_2999(ahpC) MUL_3000(ahpD)
MMI: MMAR_2754(ahpD) MMAR_2755(ahpC)
MMAE: MMARE11_26750(ahpD) MMARE11_26760(ahpC)
MLI: MULP_01008(ahpC_3) MULP_01032 MULP_02510(ahpD) MULP_02511(ahpC_2)
MSHG: MSG_02654(ahpD) MSG_02655(ahpC) MSG_04710(ohrA)
MFJ: MFLOJ_05800(ahpC) MFLOJ_05810(ahpD)
MXE: MYXE_03590(ohr) MYXE_25320(ahpC) MYXE_25330(ahpD)
MVA: Mvan_1525
MGI: Mflv_5175
MPHL: MPHLCCUG_00349(ohrB)
MMIN: MMIN_36010(ahpD) MMIN_36020
ASD: AS9A_0340
CGL: NCgl0023(Cgl0024)
CGB: cg0038
CGU: WA5_0023
CGT: cgR_0038
CGM: cgp_0038(ohr)
CGJ: AR0_00155
CEF: CE2908
CDI: DIP1419 DIP1420(dirA)
CDP: CD241_1364(ahpD) CD241_1365(ahpC)
CDH: CDB402_1330(ahpD) CDB402_1331(ahpC)
CDT: CDHC01_1363(ahpD) CDHC01_1364(ahpC)
CDE: CDHC02_1319(ahpD) CDHC02_1320(ahpC)
CDR: CDHC03_1341(ahpD) CDHC03_1342(ahpC)
CDA: CDHC04_1341(ahpD) CDHC04_1342(ahpC)
CDZ: CD31A_1436(ahpD) CD31A_1437(ahpC)
CDB: CDBH8_1413(ahpD) CDBH8_1414(ahpC)
CDS: CDC7B_1423(ahpD) CDC7B_1424(ahpC)
CDD: CDCE8392_1337(ahpD) CDCE8392_1338(ahpC)
CDW: CDPW8_1410(ahpD) CDPW8_1411(ahpC)
CDV: CDVA01_1303(ahpD) CDVA01_1304(ahpC)
CDIP: ERS451417_01441(ahpD) ERS451417_01442(ahpC)
CJK: jk1993(ohrA)
CUR: cu1883
CUA: CU7111_1814(ohrA)
CAR: cauri_1470(ahpD) cauri_1471(ahpC)
CKP: ckrop_0186 ckrop_1079(ahpC) ckrop_1080(ahpD)
CPL: Cp3995_1250(ahpD) Cp3995_1251(ahpC)
CPP: CpP54B96_1242(ahpD) CpP54B96_1243(ahpC)
CPZ: CpPAT10_1217(ahpD) CpPAT10_1218(ahpC)
COR: Cp267_1276(ahpD) Cp267_1277(ahpC)
COD: Cp106_1200(ahpD) Cp106_1201(ahpC)
COS: Cp4202_1210(ahpD) Cp4202_1211(ahpC)
CRD: CRES_2042(ohrA)
CUL: CULC22_01331(ahpD) CULC22_01332(ahpC)
CUC: CULC809_01317(ahpD) CULC809_01318(ahpC)
CUN: Cul210932_1398(ahpD) Cul210932_1400(ahpC)
CUS: CulFRC11_1305(ahpD) CulFRC11_1306(ahpC)
CUQ: Cul210931_1289(ahpD) Cul210931_1290(ahpC)
CUZ: Cul05146_1364(ahpD) Cul05146_1365(ahpC)
CGY: CGLY_07930(ahpD) CGLY_07935(ahpC)
COA: DR71_2083(ahpD) DR71_2084(ahpC) DR71_925
CSP: WM42_2185 WM42_2476(ahpC) WM42_2477(ahpD)
RER: RER_06520(osmC) RER_27860(ahpD) RER_27870(ahpC) RER_47410(ohr) RER_59400(ohr)
ROP: ROP_43420(osmC) ROP_49730(ohr)
RHU: A3Q40_02766(ohrB) A3Q40_03249(osmC) A3Q40_03910(ohrA)
GOM: D7316_00495(ohrB_1) D7316_00748(ahpD) D7316_00749(ahpC) D7316_04002(ohrB_2)
SCO: SCO2396(SC4A7.24c) SCO2986(SCE50.14c) SCO5031(ahpD) SCO5032(ahpC) SCO6531(SC5C7.16)
SMA: SAVERM_1862(osmC) SAVERM_3232(ahpC) SAVERM_3233(ahpD) SAVERM_5091(ohrB2)
SRW: TUE45_02986(ohrB_1) TUE45_03573(ohrB_2) TUE45_04494(ohrB_3) TUE45_05551(ahpD_2) TUE45_05552 TUE45_07130(osmC)
SLE: sle_12480(sle_12480) sle_26750(sle_26750) sle_26760(sle_26760) sle_42930(sle_42930) sle_48030(sle_48030)
SLX: SLAV_09835(osmC) SLAV_14375 SLAV_14380(ahpD) SLAV_25265(ohrB1) SLAV_33610(ohrB2)
SGE: DWG14_01676(osmC) DWG14_04899(ohrB_1) DWG14_05115(ohrB_2) DWG14_05882(ohrB_3)
KSK: KSE_27840(osmC) KSE_47710(ahpD) KSE_47720(ahpC) KSE_68260(ohr)
LXX: Lxx16110
CMI: CMM_0415(osmC) CMM_0709
CMC: CMN_00380(osmC) CMN_00659
MOO: BWL13_00498(ohrB) BWL13_00921(osmC) BWL13_01173(ohrA)
MLV: CVS47_01056(osmC) CVS47_03286(ohrB)
MOY: CVS54_02143(osmC)
AAU: AAur_1251(ohr) AAur_1752
KRH: KRH_22540(ohr)
XCE: Xcel_3017
IDO: I598_0676(ohrB) I598_2986(osmC)
CFL: Cfla_0597
PAC: PPA0580
PAW: PAZ_c06140(ohr)
PACC: PAC1_03010
CACN: RN83_03455
CGRN: 4412665_00890(ohrB)
PAUS: NCTC13651_00139(ohrB)
ACIJ: JS278_01663(osmC) JS278_02608(ohrA)
MPH: MLP_36970
PSIM: KR76_14510
MGG: MPLG2_3602(osmC)
TFU: Tfu_0697
NDA: Ndas_1937
STRR: EKD16_12280(ohrB)
FAL: FRAAL0026 FRAAL4492(ahpC) FRAAL4493(ahpD)
ACE: Acel_1608
BSD: BLASA_4674(osmC)
MMAR: MODMU_5160(osmC)
SEN: SACE_0187(ohrA) SACE_6968
SACC: EYD13_20505(osmC)
AMQ: AMETH_2330(osmC) AMETH_2530(osmC) AMETH_6655(ohrA)
AMYY: YIM_02105(ohrB1) YIM_16640(ohrB2) YIM_26480(ohrB3)
PAUT: Pdca_09790(osmC)
AHG: AHOG_01090(ohrB) AHOG_17500(osmC)
SAQ: Sare_2276
ASE: ACPL_4357(ohr) ACPL_8306(osmC)
ACTN: L083_3962(ohr) L083_8136(osmC)
RXY: Rxyl_0142
TRO: trd_A0547
ABAT: CFX1CAM_0201(osmC)
PBF: CFX0092_A1943(osmC)
DRA: DR_1538
DGO: DGo_CA0901(osmC) DGo_CA1241(osmC) DGo_CA1828
TRA: Trad_2541
TTH: TT_C1261
TSC: TSC_c23140(osmC)
TAQ: TO73_2081
MRB: Mrub_1108
TTR: Tter_0122
PNL: PNK_2452(osmC)
PUV: PUV_12050(osmC)
OBG: Verru16b_00247(osmC)
PLS: VT03_08615(ahpC) VT03_08620(ahpD_1) VT03_20320(ohrB)
PLH: VT85_03570(ahpD_1) VT85_03575
GMR: GmarT_14660(osmC) GmarT_56860(ahpC_2)
BVO: Pan97_35360(osmC)
GES: VT84_00825(osmC) VT84_15095(ohrB)
SACI: Sinac_0784
PBOR: BSF38_05778(osmC)
AGV: OJF2_35230(osmC) OJF2_62530 OJF2_62540(ahpD_3)
ACA: ACP_1836(ohr) ACP_2516 ACP_3043(ahpC) ACP_3044(ahpD)
ABAC: LuPra_00479(osmC_1)
GAU: GAU_2662(osmC) GAU_3674
SRU: SRU_1305(osmC)
SRM: SRM_01497(osmC)
RMR: Rmar_1364
SGN: SGRA_0706 SGRA_2681(ahpD) SGRA_2682(ahpC)
MGOT: MgSA37_01279(osmC)
CHU: CHU_2252(osmC) CHU_3759 CHU_3760(ahpC)
GFO: GFO_0518(osmC) GFO_1543(osmC)
FJG: BB050_00060(osmC_1) BB050_04075(ohrA) BB050_04081(osmC_2)
FSN: GS03_01853(osmC)
COC: Coch_1298
CBAL: M667_10470
CBAT: M666_10470
DOK: MED134_09791(osmC)
DDO: I597_0726(osmC)
ZGA: ZOBELLIA_2930(ohrB)
NDO: DDD_2632
ELB: VO54_00811(ohrA) VO54_03878(osmC)
CHZ: CHSO_0303(osmC) CHSO_1699(ohr2)
CTAK: 4412677_00636(ohrB) 4412677_02125(osmC)
AALG: AREALGSMS7_04427(osmC)
MARF: CJ739_217
MESQ: C7H62_1241
FBA: FIC_01001
NDE: NIDE0044(osmC)
NMV: NITMOv2_2000(osmC)
NJA: NSJP_1027(osmC)
HHSR: HSR6_1575
HVO: HVO_1319(osmC)
HME: HFX_1387(osmC)
 » show all
1  [PMID:10766746]
Hillas PJ, del Alba FS, Oyarzabal J, Wilks A, Ortiz De Montellano PR
The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis.
J Biol Chem 275:18801-9 (2000)
2  [PMID:12517450]
Wood ZA, Schroder E, Robin Harris J, Poole LB.
Structure, mechanism and regulation of peroxiredoxins.
Trends Biochem Sci 28:32-40 (2003)
3  [PMID:12761216]
Koshkin A, Nunn CM, Djordjevic S, Ortiz de Montellano PR
The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined  by mutagenesis, crystallography, and kinetics.
J Biol Chem 278:29502-8 (2003)
4  [PMID:15178486]
Koshkin A, Knudsen GM, Ortiz De Montellano PR
Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis.
Arch Biochem Biophys 427:41-7 (2004)
5  [PMID:16368957]
Shi S, Ehrt S
Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.
Infect Immun 74:56-63 (2006)
6  [PMID:20463026]
Cussiol JR, Alegria TG, Szweda LI, Netto LE
Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity, lipoyl-dependent peroxidase.
J Biol Chem 285:21943-50 (2010)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 207137-51-7

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