KEGG   ENZYME: 1.13.11.31
Entry
EC 1.13.11.31               Enzyme                                 

Name
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 12-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]
Reaction(KEGG)
R01596
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:C05965]
Comment
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
History
EC 1.13.11.31 created 1983
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K00458  arachidonate 12-lipoxygenase
Genes
HSA: 239(ALOX12)
PTR: 455242(ALOX12) 455243
PPS: 100992721(ALOX12)
GGO: 101140132(ALOX12)
PON: 100435170 100448016
NLE: 100605486(ALOX12)
MCC: 713748(ALOX12)
MCF: 102136652(ALOX12)
CSAB: 103242265(ALOX12)
RRO: 104673348(ALOX12)
RBB: 108514395(ALOX12)
CJC: 100400641(ALOX12)
SBQ: 101051396(ALOX12)
MMU: 11684(Alox12) 11685(Alox12e)
MCAL: 110304778(Alox12)
MPAH: 110331792(Alox12)
RNO: 287454(Alox12) 303252(Alox12e)
MUN: 110540751(Alox12)
CGE: 100764620(Alox12)
NGI: 103752172(Alox12)
HGL: 101702123(Alox12)
CCAN: 109682903(Alox12)
OCU: 100340525(ALOX12)
TUP: 102493396(ALOX12) 102494779
CFA: 479476(ALOX12)
VVP: 112924805
AML: 100471037(ALOX12)
UMR: 103660455(ALOX12)
UAH: 113271099(ALOX12)
ORO: 101379600(ALOX12)
ELK: 111161172
FCA: 101094304
PTG: 102969788(ALOX12)
PPAD: 109245992
AJU: 106972408
BTA: 407169(ALOX12) 787450(ALOX12E)
BOM: 102284543(ALOX12)
BIU: 109574004(ALOX12)
BBUB: 102395651(ALOX12)
CHX: 102187263(ALOX12)
OAS: 101113685(ALOX12)
SSC: 100620614(ALOX12)
CFR: 102504047(ALOX12)
CDK: 105103060(ALOX12)
BACU: 103020542(ALOX12)
LVE: 103074060(ALOX12)
OOR: 101279538(ALOX12)
DLE: 111185974(ALOX12)
PCAD: 102977395(ALOX12)
ECB: 100072916
EPZ: 103561430(ALOX12)
EAI: 106844160(ALOX12)
MNA: 107544244(ALOX12)
HAI: 109394599(ALOX12)
DRO: 112308919(ALOX12)
PALE: 102897481(ALOX12)
RAY: 107509504(ALOX12)
MJV: 108401224(ALOX12)
LAV: 100656524
TMU: 101341400
SHR: 100933073
PCW: 110194257
OAA: 100079469
DRE: 322732(alox12)
SANH: 107669199
SGH: 107593795
CCAR: 109050063
PHYP: 113539915
AMEX: 103037595
EEE: 113580793
TRU: 101070898
LCO: 104937156
NCC: 104948188
MZE: 101479810
ONL: 100698983
OLA: 101174953
XMA: 102224924
XCO: 114157899
PRET: 103480141
CVG: 107103814
NFU: 107384708(alox15)
KMR: 108242243(alox12)
ALIM: 106526983
AOCE: 111564179
POV: 109637629
SDU: 111223569
SLAL: 111667993
BPEC: 110170766
MALB: 109957267
SASA: 100380705(lox12) 106608934
SALP: 111952161
ELS: 105027651
SFM: 108922837
PKI: 111846328
CMK: 103190915
RTP: 109926716
 » show all
Reference
1  [PMID:4215079]
  Authors
Hamberg M, Samuelsson B.
  Title
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
  Journal
Proc Natl Acad Sci U S A 71:3400-4 (1974)
DOI:10.1073/pnas.71.9.3400
Reference
2  [PMID:804329]
  Authors
Nugteren DH.
  Title
Arachidonate lipoxygenase in blood platelets.
  Journal
Biochim Biophys Acta 380:299-307 (1975)
DOI:10.1016/0005-2760(75)90016-8
Reference
3  [PMID:6783111]
  Authors
Wallach DP, Brown VR.
  Title
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.
  Journal
Biochim Biophys Acta 663:361-72 (1981)
DOI:10.1016/0005-2760(81)90165-X
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.31
IUBMB Enzyme Nomenclature: 1.13.11.31
ExPASy - ENZYME nomenclature database: 1.13.11.31
BRENDA, the Enzyme Database: 1.13.11.31
CAS: 82391-43-3
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