| Entry |
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| Name |
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
arachidonate:oxygen 12-oxidoreductase
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| Reaction(IUBMB) |
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN: R01596]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD: C05965]
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| Comment |
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
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| History |
EC 1.13.11.31 created 1983
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| Pathway |
| ec00590 | Arachidonic acid metabolism |
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| Orthology |
| K00458 | arachidonate 12-lipoxygenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Hamberg M, Samuelsson B. |
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| Title |
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. |
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| Journal |
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| Reference |
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| Authors |
Nugteren DH. |
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| Title |
Arachidonate lipoxygenase in blood platelets. |
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| Journal |
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| Reference |
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| Authors |
Wallach DP, Brown VR. |
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| Title |
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases. |
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| Journal |
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| Other DBs |
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| LinkDB |
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