KEGG   ENZYME: 1.13.11.33
Entry
EC 1.13.11.33               Enzyme                                 

Name
arachidonate 15-lipoxygenase;
15-lipoxygenase;
linoleic acid omega6-lipoxygenase;
omega6 lipoxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 15-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [RN:R01593]
Reaction(KEGG)
R01593;
(other) R03626
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [CPD:C05966]
Comment
The product is rapidly reduced to the corresponding 15S-hydroxy compound.
History
EC 1.13.11.33 created 1984
Pathway
ec00590  Arachidonic acid metabolism
ec00591  Linoleic acid metabolism
ec01100  Metabolic pathways
Orthology
K00460  arachidonate 15-lipoxygenase
K08022  arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type)
K19246  arachidonate 15-lipoxygenase
Genes
HSA: 246(ALOX15) 247(ALOX15B)
PTR: 455104(ALOX15B) 748294(ALOX15) 750581
PPS: 100971127(ALOX15B) 100990568(ALOX15)
GGO: 101130490(ALOX15) 101138809 101141127(ALOX15B)
PON: 100174413(ALOX15) 100443582(ALOX15B)
NLE: 100598410(ALOX15) 100599862 115831495
MCC: 100425071 709212(ALOX15) 713683 716764(ALOX15B)
MCF: 102114788(ALOX15B) 102124513(ALOX15) 102137290
CSAB: 103242192(ALOX15) 103242262 103242336(ALOX15B)
RRO: 104661676(ALOX15B) 104673354 104677212(ALOX15)
RBB: 108514291(ALOX15B) 108514294 108520722(ALOX15)
CJC: 100388086(ALOX15) 100411880(ALOX15B)
SBQ: 101031385(ALOX15) 101048111(ALOX15B)
MMU: 11687(Alox15) 11688(Alox8)
MCAL: 110305643 110306013(Alox15b)
MPAH: 110332116 110332396(Alox15b)
RNO: 266604(Alox15b) 81639(Alox15)
CGE: 100754473(Alox15b) 100764916(Alox15)
NGI: 103752102(Alox15b) 103752179(Alox15)
HGL: 101698545
CCAN: 109693912(Alox15b) 109697448(Alox15)
OCU: 100009114(ALOX15) 100271999(ALOX12) 100342479(ALOX15B)
CFA: 489458(ALOX15) 489485(ALOX15B)
VVP: 112924740(ALOX15B) 112924802(ALOX15) 112924804
AML: 100475233(ALOX15B) 100479002(ALOX15)
UMR: 103660453(ALOX15) 103660486(ALOX15B)
UAH: 113271093(ALOX15) 113271172(ALOX15B)
ORO: 101379891 101380189(ALOX15) 101382890(ALOX15B)
FCA: 101101264(ALOX15B)
PTG: 102971044(ALOX15B)
PPAD: 109245909(ALOX15B)
AJU: 106972510(ALOX15B)
BTA: 282139(ALOX15) 286820(ALOX15B)
BOM: 102275513(ALOX15B) 102281419 102285373 102285661(ALOX15)
CHX: 102169702(ALOX15B) 102178853 102179132(ALOX15)
OAS: 101116587(ALOX15) 101121185
SSC: 100525835 396971(ALOX15)
BACU: 102998643(ALOX15B) 103006231(ALOX15)
LVE: 103073785(ALOX15) 103084519(ALOX15B)
OOR: 101281563(ALOX15) 101281720
DLE: 111185769 111185975(ALOX15)
PCAD: 102976974(ALOX15B) 102986457(ALOX15)
ECB: 100072900(ALOX15) 100073039(ALOX15B)
EPZ: 103561432(ALOX15) 103564283(ALOX15B)
EAI: 106844146 106844159(ALOX15) 106844231(ALOX15B)
MYB: 102240358
MNA: 107528023(ALOX15)
HAI: 109394595(ALOX15) 109395112
DRO: 112308861(ALOX15)
PALE: 102891969 102896986(ALOX15)
RAY: 107509499(ALOX15)
MJV: 108383388(ALOX15B) 108386766(ALOX15)
MDO: 100015976(ALOX15)
SHR: 100921165(ALOX15B)
PCW: 110194258
CJO: 107307257
LSR: 110483683
CMY: 102946254
CPIC: 101943453
TSR: 106553882
CCAR: 109045230
PHYP: 113541501
EEE: 113573261
LCO: 104934305
NFU: 107375272
ALIM: 106519785
AOCE: 111570982
CSEM: 103383522
POV: 109638289
SLAL: 111655595
MALB: 109952244
SFM: 108934212
PKI: 111852905
RTP: 109917782
SKO: 100372903
CRG: 105333212
MGR: MGG_08499
CLAP: NCTC11466_02735(lox_2)
PAE: PA1169
PAEV: N297_1207(lox)
PAEI: N296_1207(lox)
PAEP: PA1S_20055
PAEM: U769_19925
PAEL: T223_21220
PAEC: M802_1203(lox)
PAEO: M801_1207(lox)
SDN: Sden_1680
SVO: SVI_2441
SPSW: Sps_04756
NWA: Nwat_1315
BTE: BTH_I2353
BTQ: BTQ_1567(lox)
BTJ: BTJ_790(lox)
BTV: BTHA_2232(lox)
BTHE: BTN_2734(lox)
BTHM: BTRA_2312(lox)
BTHL: BG87_2254(lox)
NEU: NE1239(ALOX5)
SMAZ: LH19_19595
SECH: B18_17525
SFLA: SPHFLASMR4Y_00458(lox)
NSR: NS506_06256(loxA)
MAR: MAE_42740
CYT: cce_2648
NSP: BMF81_03731(loxA)
DOU: BMF77_01845(lox)
FMR: Fuma_06255(lox)
GES: VT84_11305(lox_1) VT84_28760(lox_2)
 » show all
Reference
1  [PMID:6804460]
  Authors
Bryant RW, Bailey JM, Schewe T, Rapoport SM.
  Title
Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.
  Journal
J Biol Chem 257:6050-5 (1982)
Reference
2  [PMID:6813644]
  Authors
Narumiya S, Salmon JA.
  Title
Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes.
  Journal
Methods Enzymol 86:45-8 (1982)
DOI:10.1016/0076-6879(82)86166-1
Reference
3  [PMID:2496760]
  Authors
Oliw EH, Sprecher H.
  Title
Metabolism of polyunsaturated fatty acids by an (n - 6)-lipoxygenase associated with human ejaculates.
  Journal
Biochim Biophys Acta 1002:283-91 (1989)
DOI:10.1016/0005-2760(89)90342-1
Reference
4  [PMID:3112136]
  Authors
Shibata D, Steczko J, Dixon JE, Hermodson M, Yazdanparast R, Axelrod B.
  Title
Primary structure of soybean lipoxygenase-1.
  Journal
J Biol Chem 262:10080-5 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.33
IUBMB Enzyme Nomenclature: 1.13.11.33
ExPASy - ENZYME nomenclature database: 1.13.11.33
BRENDA, the Enzyme Database: 1.13.11.33
CAS: 82249-77-2
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