| Entry |
|
| Name |
arachidonate 15-lipoxygenase;
15-lipoxygenase;
linoleic acid omega6-lipoxygenase;
omega6 lipoxygenase
|
| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
|
| Sysname |
arachidonate:oxygen 15-oxidoreductase
|
| Reaction(IUBMB) |
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [RN: R01593]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [CPD: C05966]
|
| Comment |
The product is rapidly reduced to the corresponding 15S-hydroxy compound.
|
| History |
EC 1.13.11.33 created 1984
|
| Pathway |
| ec00590 | Arachidonic acid metabolism |
|
| Orthology |
| K00460 | arachidonate 15-lipoxygenase |
| K08022 | arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) |
| K19246 | arachidonate 15-lipoxygenase |
|
| Genes |
| HSA: | 246(ALOX15) 247(ALOX15B) |
| PTR: | 455104(ALOX15B) 748294(ALOX15) |
| PPS: | 100971127 100990568(ALOX15) |
| GGO: | 101130490(ALOX15) 101141127(ALOX15B) |
| PON: | 100174413(ALOX15) 100443582(ALOX15B) |
| PPYG: | 129016925(ALOX15B) 129018111(ALOX15) |
| NLE: | 100598410(ALOX15) 115831495 |
| SSYN: | 129470266(ALOX15) 134731306 |
| MCC: | 100425071 709212(ALOX15) 716764(ALOX15B) |
| MCF: | 102114788(ALOX15B) 102124513(ALOX15) |
| MNI: | 105472240(ALOX15) 105473860(ALOX15B) |
| CSAB: | 103242192(ALOX15) 103242336(ALOX15B) |
| CATY: | 105581986(ALOX15B) 105583615(ALOX15) |
| PANU: | 101014249(ALOX15) 101016522 101017215(ALOX15B) |
| TGE: | 112609407(ALOX15B) 112609437(ALOX15) 112610174 |
| MLEU: | 105539984(ALOX15) 105549854(ALOX15B) |
| RRO: | 104661676(ALOX15B) 104677212(ALOX15) |
| RBB: | 108514291(ALOX15B) 108520722(ALOX15) |
| TFN: | 117067740(ALOX15B) 117067883(ALOX15) |
| CANG: | 105523522(ALOX15) 105523638(ALOX15B) 105523680 |
| CJC: | 100388086(ALOX15) 100411880(ALOX15B) |
| SBQ: | 101031385(ALOX15) 101048111(ALOX15B) |
| CIMI: | 108306442 108306450(ALOX15B) |
| ANAN: | 105714417(ALOX15) 105720823(ALOX15B) |
| CSYR: | 103253284(ALOX15) 103263441(ALOX15B) |
| MMUR: | 105877322(ALOX15B) 105879207(ALOX15) 105879210 |
| LCAT: | 123621261(ALOX15) 123650917(ALOX15B) |
| ERUF: | 138392517(ALOX15B) 138392544(ALOX15) |
| PCOQ: | 105819392(ALOX15B) 105822846(ALOX15) |
| OGA: | 100953458(ALOX15) 100959028(ALOX15B) |
| MMU: | 11687(Alox15) 11688(Alox8) |
| MCAL: | 110305643 110306013(Alox15b) |
| MPAH: | 110332116 110332396(Alox15b) |
| RNO: | 266604(Alox15b) 81639(Alox15) |
| ANU: | 117710292 117710957(Alox15) 117711361 117711372 |
| ASYL: | 127694664 127694689 127694865 |
| MMIU: | 308425486(ALOX15B) 308426432(LOC308426432) |
| MUN: | 110542750(Alox15) 110551727(Alox15b) |
| PLEU: | 114693239(Alox15b) 114693249 |
| PMAV: | 102924596 102927075(Alox15b) |
| MORG: | 121456877(Alox15) 121456903(Alox15b) |
| MFOT: | 126514012 126514045 |
| AAMP: | 119812940(Alox15) 119813001(Alox15b) |
| CNL: | 130877572 130878135(Alox15b) |
| NGI: | 103752102(Alox15b) 103752179(Alox15) |
| CCAN: | 109693912(Alox15b) 109697448(Alox15) |
| DORD: | 105983203 105983296 105983343 105983401(Alox15b) |
| DSP: | 122100398 122100427(Alox15b) 122100448 122108619 |
| DMER: | 138813161(Alox15b) 138813171 138813172 138813280 |
| PLOP: | 125365627(Alox15b) 125365834 125365978 |
| NCAR: | 124980374 124980592 |
| SVUL: | 306655946(ALOX15B) 306656221(ALOX15) |
| MMMA: | 107158069(Alox15b) 107159314(Alox15) |
| ITI: | 101961928(Alox15b) 101973674(Alox15) |
| SCIL: | 308635936(LOC308635936) 308636473(ALOX15B) 308636744(LOC308636744) 308636949(LOC308636949) |
| MAVE: | 308274596(ALOX15B) 308275076(LOC308275076) 308275077(LOC308275077) 308275600(LOC308275600) |
| OCU: | 100009114(ALOX15) 100342479 |
| OPI: | 101518498(ALOX15) 101525136(ALOX15B) |
| OCZ: | 121170009(ALOX15) 121170021(ALOX15B) |
| TUP: | 102478167(ALOX15) 102488255 102494778 102495182(ALOX15B) |
| GVR: | 103588408 103593649(ALOX15B) |
| CFA: | 489458(ALOX15) 489485(ALOX15B) |
| CLUD: | 112647413(ALOX15B) 112647513(ALOX15) |
| VVP: | 112924740(ALOX15B) 112924802(ALOX15) |
| VLG: | 121500300(ALOX15B) 121500376 |
| NPO: | 129497273(ALOX15) 129497891 129497924(ALOX15B) |
| AML: | 100475233(ALOX15B) 100479002(ALOX15) |
| UMR: | 103660453(ALOX15) 103660486(ALOX15B) |
| UAH: | 113271093(ALOX15) 113271172(ALOX15B) |
| UAR: | 123792117(ALOX15B) 123792173(ALOX15) |
| MPUF: | 101672354(ALOX15B) 101685913 |
| MNP: | 132003156(ALOX15B) 132004425 |
| MLK: | 131816017(ALOX15B) 131816515 |
| NVS: | 122907757 122907777(ALOX15B) |
| MMAQ: | 308356799(ALOX15B) 308357445(LOC308357445) |
| ORO: | 101380189(ALOX15) 101382890(ALOX15B) |
| EJU: | 114225420(ALOX15B) 114225435 |
| ZCA: | 113907894(ALOX15B) 113908304 |
| MLX: | 117999900(ALOX15B) 117999977 |
| MANO: | 123853595(ALOX15B) 123854581 |
| NSU: | 110584449 110584496 110584661(ALOX15B) |
| LWW: | 102732006 102739995(ALOX15B) 102750374 |
| LGF: | 123602993(ALOX15B) 123604211 |
| HHV: | 120227740 120231436(ALOX15B) |
| CCRU: | 144217143(ALOX15B) 144217259(ALOX15) |
| BTA: | 282139(ALOX15) 286820(ALOX15B) |
| BOM: | 102275513 102285661(ALOX15) |
| BJV: | 133231376(ALOX15B) 133232022 |
| BBUB: | 102397311(ALOX15) 102407045(ALOX15B) |
| BBIS: | 104990752 104990889 104993943 |
| OAS: | 101116587(ALOX15) 101121185 |
| OCAN: | 138447424(ALOX15) 138447493 |
| BTAX: | 128065061 128065115 |
| CSUM: | 138083074 138084752 |
| CCAD: | 122446170 122446330 |
| MREE: | 136148954(ALOX15) 136149466 |
| MBEZ: | 129542456 129543357(ALOX15B) |
| SSC: | 100525835 396971(ALOX15) |
| CFR: | 102517336 102522465 116669221 |
| CBAI: | 105066404(ALOX15) 105077528(ALOX15B) |
| CDK: | 105102997(ALOX15B) 105106001 116157868 |
| VPC: | 102528849(ALOX15B) 102544743(ALOX15) |
| BACU: | 102998643(ALOX15B) 103006231(ALOX15) |
| BMUS: | 118886906(ALOX15B) 118887047(ALOX15) |
| LVE: | 103073785(ALOX15) 103084519(ALOX15B) |
| OOR: | 101281563(ALOX15) 101281720 |
| LALB: | 132510931(ALOX15B) 132511482(ALOX15) |
| GMF: | 115855855 115856204(ALOX15) |
| DDP: | 132414259(ALOX15) 132415124 |
| SCOO: | 307177389(ALOX15) 307177856(ALOX15B) |
| PCRS: | 137211919(ALOX15B) 137212513(ALOX15) |
| DLE: | 111185769 111185975(ALOX15) |
| PCAD: | 102976974(ALOX15B) 102986457(ALOX15) |
| PSIU: | 116745707(ALOX15) 116745711(ALOX15B) |
| PPHC: | 136137980(ALOX15) 136139207 |
| NASI: | 112394032(ALOX15) 112401898 |
| ECB: | 100072900(ALOX15) 100073039(ALOX15B) |
| EAI: | 106844159(ALOX15) 106844231(ALOX15B) |
| MLF: | 102421516 102421821 102427209 102427827 102433865 106694362 |
| MYUM: | 138993692 138994085 138994127 138994149 138994311 138994406 |
| PKL: | 118726749 118726750 118726751 |
| EFUS: | 103299846(ALOX15) 129147367 |
| POTS: | 308253516(AC0HY7_020349) 308254536(AC0HY7_021369) |
| HAI: | 109394595(ALOX15) 109395112 |
| PALE: | 102891969 102896986(ALOX15) |
| TOD: | 119231205 119232067 119232330 |
| LAV: | 100660599 100671025(ALOX15B) 104845446 |
| TMU: | 101354837 101355099 101359454 |
| PBRV: | 138142170 138174025 |
| CAUA: | 113043657 113072679 |
| CGIB: | 127934057 128013818 128014767 |
| PPRM: | 120462449 120474964 120476342 120477429 120478400 120479205 120480164 |
| MAMB: | 125244160 125244167 125246017 125246255 125261560 125261680 125263302 125265930 125265931 125268876 |
| CIDE: | 127494873 127503978 127508777 127508778 127516795 |
| CERY: | 137004278 137005285 137005344 137005416 137005633 137006382 137006389 137007099 137014199 137014399 137029949 137031046 |
| NGRA: | 132867245 132867249 132867254 132867301 |
| AMEX: | 103026959 103036852 103039932 111190048 111190674 125782391 125782392 |
| CMAO: | 118800210 118800215 118810850 118810852 118810863 118811084 118815182 118820209 118820210 118820471 118822917 |
| CHAR: | 105891414 105892241 105893241 105898612 105904243 105904244 105904246 105908834 105910728(si:dkey-17e16.9) 116221755 116221948 122129338 |
| SPIL: | 134068630 134076004 134078100 134087020 134087030 134088129 134088140 134088154 134088169 134088181 |
| ASAD: | 121717892 121718572 121718577 121718578 |
| TBEN: | 117470222 117481933 117481934 117481940 117481942 117481962 117481964 117482229 117482230 117482231 117482233 117482284 117482285 117482287 117482288 117482289 117482290 117482291 117482292 |
| CGOB: | 115009844 115010916 115014711 115015183 115015193 115018543 |
| PGEO: | 117440519 117447477 117447534 117452876 |
| GACU: | 117537746 117537750 117547981 117555310 117555313 |
| EMAC: | 134865257 134865296 134871723(zgc:152891) |
| ELY: | 117254584 117254597 117254602 117254834 117254937 117254947 117255063 117266846 117271170 144458319 144462469 144462541 144462542 |
| EFO: | 125883499 125884274 125884311 125884329 125884340 125884350 125885404 125885405 125885406 125898661(zgc:152891) |
| PLEP: | 121941966 121941967 121942039 121942559 121953099(zgc:152891) |
| SLUC: | 116034395 116036443 116036660 116039739 116044067 116054988 116065866 |
| ESP: | 116675869 116680795 116681694 116697797 116701622 |
| PFLV: | 114562807 114566285 114566432 114566433 114566434 114567140 114567161 114574044 114574045 |
| PPUG: | 119227035 134107856 |
| AFB: | 129095944 129114026(zgc:152891) |
| CLUM: | 117733736 117737934 117742597(zgc:152891) |
| PSWI: | 130189663 130190525 |
| CANA: | 137788053(zgc:152891) 137793093 |
| CVE: | 137884928 137885010 137885131 137885489 137888325(zgc:152891) |
| MSAM: | 119895614(zgc:152891) 119898927 119898956 119914853 |
| SCHU: | 122865861 122872964 122873997 122887789(zgc:152891) |
| EARM: | 139290825 139291498 139291732 139295228 139301318 139301329 139301422 139303334 |
| CUD: | 121507916 121508342 121508343 121508538 121508638 121508696 121508734 121508827 121519044(zgc:152891) |
| SPUL: | 138594297 138594528 138594557 138595319 138595320 138598067 |
| LMIX: | 132954946 132988437(zgc:152891) 132990208 132990211 132990440 132990448 132990456 |
| HTC: | 141800214 141803937 141805109 141805351 141807318 141807336 141807760 |
| ALAT: | 119011326 119011392 119020453 119020471 119020488 119020499 119020523 119030911(zgc:152891) |
| PKLU: | 139198644 139213433 139225391 |
| OLA: | 101159319 101161284 101162054 101162978 101163757 101165239 101165945 101172589 101174158 110014609 111947934 |
| OML: | 112137719 112137720 112138174 112138646(zgc:152891) 112141398 112141399 112141401 112157166 112157253 |
| CSAI: | 133419751 133438278 133450677 133450782 133451310 133451311 133451467 133454799 133459266(zgc:152891) |
| XHE: | 116719544 116720456 116720772 116728488 116729360 |
| PRET: | 103459850 103461267 103461280 103467556 |
| PFOR: | 103129739 103136600 103148488 103148508 103153212 |
| PLAI: | 106950811 106951879 106951880 106951881 106960397 106964176 |
| PMEI: | 106906711 106909730 106909731 106917334 106922288 106925463 |
| GAF: | 122829020 122829021 122830234 122845455(zgc:152891) |
| PPRL: | 129367292 129370665(zgc:152891) |
| CVG: | 107082932 107095866 107104213 |
| CTUL: | 119773828 119781209(zgc:152891) 119794445 119794446 119794447 |
| GMU: | 124867860 124868793 124868811 124876399(zgc:152891) 124878254 |
| KMR: | 108245609 108248081 108248088 |
| NWH: | 119408041 119420756(zgc:152891) |
| LTU: | 140276715 140279997 140305932 140305933 140305935 140305936 |
| MCEP: | 125003249 125003265 125021475(zgc:152891) |
| AOCE: | 111570982(si:dkey-17e16.9) 111570984 |
| BFRE: | 138615619 138627373 |
| SSEN: | 122760060 122770688 122779805(zgc:152891) |
| SSOE: | 131458580(zgc:152891) 131466339 131466564 |
| HHIP: | 117762223 117764455 117765144 |
| HSP: | 118116182 118116190 118116197 124854466 |
| PPLT: | 128436546 128436547 128436548 128436549 |
| SMAU: | 118300215(zgc:152891) 118313026 |
| SSCV: | 125969409 125969411 125969412 125969422 |
| SBIA: | 133505751 133505975 133505976 133505977 133505978 133506178 133506213 133506654 |
| PEE: | 133403736 133404085 133404138 133404154 133404469 |
| PTAO: | 133476835 133476836 133476841 133476842 133476843 |
| BPEC: | 110159844(alox12) 110162083 110165260 110165307 110165361 110174943 110175040 110175541 |
| ENY: | 140364895 140374764 140377262 |
| BSPL: | 114856233 114863291 114863312 114863328 114863344 114863360 114863402 114867365 114869596(zgc:152891) |
| SJO: | 128354042 128365644 128369133 128371717(zgc:152891) |
| SSCO: | 133988284 133988292 133993619(zgc:152891) 134006562 |
| GMH: | 115537318 115537321 115537582 115537653 |
| SASA: | 100194745(loxe3) 106593018 |
| STRU: | 115191716 115191717 115191719 115202006 115202303 115202304 |
| OMY: | 110497317 110517354 110534564 |
| OGO: | 124020729 124020730 124020731 124020732 124022296 124022297 124027072 |
| OKI: | 109876668 109877031 109877533 109877599 116352906 |
| OKE: | 118375669 127907890 127929205 |
| OMM: | 135507075 135507078 135539222 |
| OCLA: | 139419111 139419112 139419113 139419326 |
| SNH: | 120034758 120034995 120034996 120035025 120035040 120035180 120040129 120040132 120040133 120040134 |
| SFON: | 129855950 129855952 |
| CCLU: | 121556735 121556739 121556746 121564118 |
| ELS: | 105020997 105021020 105029901 |
| OEP: | 134033963 134034334 134034335 134034336 134038610 134038631 |
| PSPA: | 121297561 121303694 121319185 |
| ARUT: | 117427044 117968604 |
| BFO: | 118414775 118414896 118426947 118429456 |
| BBEL: | 109467293 109467418 109471323 109488215 |
| AFIL: | 140140123 140150948 |
| CLAP: | NCTC11466_02735(lox_2) |
| XBA: | C7S18_00355 C7S18_08820 C7S18_10525 |
| GKD: | K6Q96_09325 K6Q96_14850 |
| SWD: | Swoo_2318 Swoo_2919 Swoo_3415 |
| SHEM: | HWQ47_04015 HWQ47_19565 |
| SFLA: | SPHFLASMR4Y_00458(lox) |
| AGE: | AA314_00836 AA314_01143 |
| AVM: | JQX13_11260 JQX13_27420 |
| MBD: | MEBOL_001824 MEBOL_002184 |
| CFUS: | CYFUS_002292 CYFUS_005719 |
| SCU: | SCE1572_24150 SCE1572_27890 |
| SORG: | NQZ70_04142(lox_1) NQZ70_05894(lox_2) |
| GES: | VT84_11305(lox_1) VT84_28760(lox_2) |
| AMR: | AM1_0817 AM1_3564 AM1_3903 |
| ACAM: | HRE53_14505 HRE53_16040 HRE53_30315 |
| NPU: | Npun_F6548 Npun_R0559 |
| NOP: | Nos7524_1960 Nos7524_4652 |
| NFL: | COO91_02525 COO91_10101 |
| NPZ: | ACX27_13835 ACX27_26605 |
| NLK: | NIES25_01220 NIES25_18140 NIES25_47040 |
| NOST: | GJB62_05385 GJB62_25815 |
| ACY: | Anacy_2339 Anacy_5241 |
| NSPH: | BDGGKGIB_02222(lox) |
| RIV: | Riv7116_3956 Riv7116_6077 |
| TTQ: | NIES37_38400 NIES37_38410 NIES37_59800 |
| ALAX: | NIES50_26740 NIES50_48180 NIES50_48190 |
| BSEN: | DP114_13165 DP114_29670 |
| BOX: | DP113_13105 DP113_29830 |
» show all
|
| Reference |
|
| Authors |
Bryant RW, Bailey JM, Schewe T, Rapoport SM. |
| Title |
Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid. |
| Journal |
J Biol Chem 257:6050-5 (1982) |
| Reference |
|
| Authors |
Narumiya S, Salmon JA. |
| Title |
Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. |
| Journal |
|
| Reference |
|
| Authors |
Oliw EH, Sprecher H. |
| Title |
Metabolism of polyunsaturated fatty acids by an (n - 6)-lipoxygenase associated with human ejaculates. |
| Journal |
|
| Reference |
|
| Authors |
Shibata D, Steczko J, Dixon JE, Hermodson M, Yazdanparast R, Axelrod B. |
| Title |
Primary structure of soybean lipoxygenase-1. |
| Journal |
J Biol Chem 262:10080-5 (1987) |
| Other DBs |
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| LinkDB |
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