KEGG   ENZYME: 1.13.11.78
Entry
EC 1.13.11.78               Enzyme                                 

Name
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming);
phnZ (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Reaction(IUBMB)
(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate [RN:R10722]
Reaction(KEGG)
R10722
Substrate
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
O2 [CPD:C00007]
Product
glycine [CPD:C00037];
phosphate [CPD:C00009]
Comment
Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.
History
EC 1.13.11.78 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
K21196  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Genes
BFO: 118428300
CIN: 101242664
SPU: 100894127
APLC: 110978365
SKO: 100376109
PVM: 113811511
LGI: LOTGIDRAFT_172204
MYI: 110460342
OBI: 106870487
LAK: 106156700
EPA: 110244149
AMIL: 114975294
PDAM: 113683386
SPIS: 111325752
DGT: 114526236
QSU: 111995343
MAW: MAC_01243
MAJ: MAA_09260
CMT: CCM_06455
ANG: ANI_1_2760024(An02g08160)
SMIN: v1.2.002470.t1(symbB.v1.2.002470.t1)
PPT: PPS_4982
PPUH: B479_25155
PPUN: PP4_51980
PPUD: DW66_5375
PMON: X969_24605
PMOT: X970_24240
PFL: PFL_5886
PPRO: PPC_5834
PFS: PFLU_5807
PMAN: OU5_3801
PEN: PSEEN0270
PBA: PSEBR_a22
PSEM: TO66_29740
PSOS: POS17_5830
PANR: A7J50_5534
PSIL: PMA3_28680
LHA: LHA_1529
HCH: HCH_03080
CVI: CV_1839
BVE: AK36_3217
BUK: MYA_3169
BFN: OI25_4326
ACRA: BSY15_1906
HYB: Q5W_05110
TMO: TMO_2076
MJL: Mjls_1317
MVA: Mvan_0055
MMAG: MMAD_04990
MAIC: MAIC_30640
MCHE: BB28_07475
MSTE: MSTE_01481
REQ: REQ_18540
GBR: Gbro_1303
STRM: M444_29390
SRJ: SRO_6267
SAQ: Sare_2635
SYND: KR52_11180
RUL: UC8_38880
PLM: Plim_0646
CPI: Cpin_2968
MUC: MuYL_1124
SLI: Slin_3397
FAE: FAES_5432
 » show all
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
Reference
2  [PMID:24198335]
  Authors
Worsdorfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME
  Title
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases.
  Journal
Proc Natl Acad Sci U S A 110:18874-9 (2013)
DOI:10.1073/pnas.1315927110
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.78
IUBMB Enzyme Nomenclature: 1.13.11.78
ExPASy - ENZYME nomenclature database: 1.13.11.78
BRENDA, the Enzyme Database: 1.13.11.78
LinkDB

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