KEGG   ENZYME: 1.13.11.90
Entry
EC 1.13.11.90               Enzyme                                 

Name
[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming);
tmpB (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate:oxygen 1R-oxidoreductase (glycine-betaine-forming)
Reaction(IUBMB)
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + phosphate [RN:R12614]
Reaction(KEGG)
R12614
Substrate
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate [CPD:C22271];
O2 [CPD:C00007]
Product
glycine betaine [CPD:C00719];
phosphate [CPD:C00009]
Comment
Requires Fe2+. This bacterial enzyme is involved in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.
History
EC 1.13.11.90 created 2020
Orthology
K24290  [1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase
Genes
MARJ: MARI_16710
HAF: C8233_04170
MARS: A8C75_09135
TSN: W908_07690
THIN: CRN91_02450
PMEG: FNZ07_29580
MLO: mll1439
MLN: A9174_18905
MCI: Mesci_3238
MOP: Mesop_3630
MHUA: MCHK_3076
SIL: SPO3381
PGD: Gal_00706
LAQU: R2C4_08475
AHEL: Q31a_61960
 » show all
Reference
1  [PMID:30789718]
  Authors
Rajakovich LJ, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM Jr
  Title
A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.
  Journal
Biochemistry 58:1627-1647 (2019)
DOI:10.1021/acs.biochem.9b00044
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.90
IUBMB Enzyme Nomenclature: 1.13.11.90
ExPASy - ENZYME nomenclature database: 1.13.11.90
BRENDA, the Enzyme Database: 1.13.11.90
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