KEGG   ENZYME: 1.13.12.21
Entry
EC 1.13.12.21               Enzyme                                 

Name
tetracenomycin-F1 monooxygenase;
tcmH (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
tetracenomycin-F1:oxygen C5-monooxygenase
Reaction(IUBMB)
tetracenomycin F1 + O2 = tetracenomycin D3 + H2O [RN:R06700]
Reaction(KEGG)
R06700
Substrate
tetracenomycin F1 [CPD:C12367];
O2 [CPD:C00007]
Product
tetracenomycin D3 [CPD:C12368];
H2O [CPD:C00001]
Comment
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
History
EC 1.13.12.21 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15969  tetracenomycin F1 monooxygenase
Genes
SGU: SGLAU_26340(tcmH)
Reference
1  [PMID:8329392]
  Authors
Shen B, Hutchinson CR.
  Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:6656-63 (1993)
DOI:10.1021/bi00077a019
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.21
IUBMB Enzyme Nomenclature: 1.13.12.21
ExPASy - ENZYME nomenclature database: 1.13.12.21
BRENDA, the Enzyme Database: 1.13.12.21
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