KEGG   ENZYME: 1.14.11.27
Entry
EC 1.14.11.27               Enzyme                                 

Name
[histone H3]-dimethyl-L-lysine36 demethylase;
KDM2A (gene name);
KDM2B (gene name);
JHDM1A (gene name);
JHDM1B (gene name);
JmjC domain-containing histone demethylase 1A;
H3-K36-specific demethylase (ambiguous);
histone-lysine (H3-K36) demethylase (ambiguous);
histone demethylase (ambiguous);
protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase;
protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase;
[histone-H3]-lysine-36 demethylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6-dimethyl-L-lysine36,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R10056];
(1a) a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 [RN:R09510];
(1b) a [histone H3]-N6-methyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine36 + succinate + formaldehyde + CO2 [RN:R09511]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6-dimethyl-L-lysine36;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6-methyl-L-lysine36
Product
[histone H3]-L-lysine36;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6-methyl-L-lysine36
Comment
Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys36 (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys36. It can also demethylate monomethylated (but not the trimethylated) Lys36. cf. EC 1.14.11.69, [histone H3]-trimethyl-L-lysine36 demethylase.
History
EC 1.14.11.27 created 2006, modified 2019
Orthology
K10276  F-box and leucine-rich repeat protein 10/11
K16914  bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
K24444  [histone H3]-dimethyl/trimethyl-L-lysine36 demethylase
Genes
HSA: 22992(KDM2A) 79697(RIOX1) 84678(KDM2B)
PTR: 104002100(RIOX1) 107967129(KDM2A) 465184(KDM2B)
PPS: 100983162(KDM2A) 100988129(KDM2B) 103787047(RIOX1)
GGO: 101140212(KDM2A) 101154151(KDM2B)
PON: 100434567(KDM2A) 100462645(KDM2B) 103892384(RIOX1)
NLE: 100579905(KDM2B) 100601545(KDM2A) 105739243(RIOX1)
MCC: 696773(RIOX1) 699938(KDM2B) 712907(KDM2A)
MCF: 102125851(KDM2B) 102135352(RIOX1) 102142242(KDM2A)
CSAB: 103219229(KDM2A) 103229309(RIOX1) 103239283(KDM2B)
RRO: 104656344(RIOX1) 104664750(KDM2A) 104666275(KDM2B)
RBB: 108518607(KDM2A) 108529633(KDM2B) 108536225(RIOX1)
CJC: 100397900(KDM2B) 100403232(KDM2A) 100404196(RIOX1)
SBQ: 101044630(KDM2B) 101049444(KDM2A) 104650789
MMU: 225876(Kdm2a) 30841(Kdm2b) 71952(Riox1)
MCAL: 110285231(Kdm2a) 110294179(Kdm2b) 110307186(Riox1)
MPAH: 110324497(Riox1) 110337427(Kdm2a) 110339091(Kdm2b)
RNO: 304495(Kdm2b) 314300(RGD1307704) 361700(Kdm2a)
MUN: 110545328(Kdm2b) 110558535(Riox1) 110560366(Kdm2a)
CGE: 100763039(Kdm2a) 100767158(Kdm2b)
NGI: 103725573(Kdm2a) 103739068(Kdm2b) 103747411(Riox1)
HGL: 101696346(Kdm2b) 101712659(Riox1) 101713712(Kdm2a)
CCAN: 109684942 109684944(Kdm2a) 109686393(Kdm2b) 109691362(Riox1)
OCU: 100349603(KDM2B) 100352993(KDM2A) 103351690(RIOX1)
TUP: 102482421(KDM2A) 102484507(RIOX1) 102488934(KDM2B)
CFA: 106559177(RIOX1) 483702(KDM2A) 486262(KDM2B)
VVP: 112924192(KDM2A) 112927248(RIOX1) 112935168(KDM2B)
AML: 100467038(KDM2B) 100468557(RIOX1) 100469601(KDM2A)
UMR: 103661272(KDM2B) 103673481(RIOX1) 103679509(KDM2A)
UAH: 113244041(KDM2A) 113266944(KDM2B) 113270360(RIOX1)
ORO: 101368497(KDM2B) 101379219 101385046(KDM2A)
FCA: 101090549(KDM2A) 101094455(KDM2B) 102900260(RIOX1)
PTG: 102959050(KDM2A) 102960977(RIOX1) 102971585(KDM2B)
PPAD: 109246832(KDM2A) 109253798(CUNH14orf169) 109277681(KDM2B)
AJU: 106967547(KDM2B) 106971187(KDM2A) 106974332(RIOX1)
BTA: 511031(RIOX1) 540141(KDM2A) 614487(KDM2B)
BOM: 102274509(KDM2B) 102285244(RIOX1) 102286032(KDM2A)
BIU: 109554334(KDM2A) 109565323(RIOX1) 109571124(KDM2B)
BBUB: 102398958(KDM2B) 102399656(RIOX1) 102407952(KDM2A)
CHX: 102173094(RIOX1) 102180467(KDM2A) 102180525(KDM2B)
OAS: 101103759(KDM2B) 101108003(KDM2A) 105606501(RIOX1)
SSC: 100294703(KDM2A) 100512074(KDM2B) 100523074(RIOX1)
CFR: 102503719(KDM2B) 102505373(RIOX1) 102523384(KDM2A)
CDK: 105086126(RIOX1) 105102511(KDM2B) 105104438(KDM2A)
BACU: 103004183(KDM2B) 103010328 103014019(RIOX1) 103019182(KDM2A)
LVE: 103069841(RIOX1) 103076521(KDM2A) 103088952(KDM2B)
OOR: 101275960 101280158(KDM2B)
DLE: 111176276(RIOX1) 111183686(KDM2A) 111186955(KDM2B)
PCAD: 102978197(KDM2B) 102980914(RIOX1) 102995738(KDM2A)
ECB: 100052955(KDM2A) 100059690(KDM2B) 100146448(RIOX1)
EPZ: 103541690(KDM2B) 103559839(KDM2A) 103567990(RIOX1)
EAI: 106827705(RIOX1) 106833507(KDM2A) 106842217(KDM2B)
MYB: 102249116(KDM2A) 102253219(KDM2B) 102256784(RIOX1)
MYD: 102751904(KDM2B) 102757410(RIOX1) 102768553(KDM2A)
MNA: 107529559(KDM2B) 107533472 107533588(KDM2A)
HAI: 109381570(RIOX1) 109384201(KDM2A) 109386110(KDM2B)
DRO: 112310458(KDM2B) 112311546(RIOX1) 112317322(KDM2A)
PALE: 102883377(KDM2B) 102887644(RIOX1) 102893981(KDM2A)
RAY: 107503783(KDM2A) 107505016 107515252(KDM2B)
MJV: 108390401(KDM2B) 108393149(KDM2A) 108397196(CUNH14orf169)
LAV: 100668526(RIOX1) 100669609(KDM2B) 100672180(KDM2A)
MDO: 100015947(KDM2B) 100024523(RIOX1) 100029240(KDM2A) 103104734
SHR: 100925042(KDM2A) 105750349(RIOX1)
PCW: 110195381(KDM2A) 110196804(KDM2B) 110208359(RIOX1)
OAA: 100079482(KDM2B) 100084241(KDM2A) 100086314(RIOX1)
GGA: 416844(KDM2B) 423249(C5H14ORF169) 425999(KDM2A)
MGP: 100544042(KDM2B) 100545882(RIOX1) 100551270(KDM2A)
CJO: 107314187(KDM2A) 107314864(RIOX1) 107321115(KDM2B)
NMEL: 110400817(KDM2A) 110401899(RIOX1) 110406580(KDM2B)
APLA: 101791557(KDM2B) 101795359 101796505(RIOX1)
ACYG: 106029324(KDM2A) 106031144(KDM2B) 106040700
TGU: 100218907(KDM2B) 100219109(RIOX1) 100230512(KDM2A)
LSR: 110471756(KDM2B) 110472176(RIOX1) 110484936(KDM2A)
SCAN: 103818165(KDM2B) 103822131(KDM2A) 103826967(RIOX1)
GFR: 102033306(KDM2A) 102035608(RIOX1) 102045075(KDM2B)
FAB: 101813982(KDM2B) 101818982(KDM2A) 101819482(RIOX1)
PHI: 102111633(RIOX1) 102113870(KDM2B) 102114250(KDM2A)
PMAJ: 107205486(C5H14orf169) 107206215(KDM2A) 107211564(KDM2B)
CCAE: 111930251(RIOX1) 111930406(KDM2A) 111936391(KDM2B)
CCW: 104684132 104688287(RIOX1) 104688702(KDM2B)
ETL: 114054942(KDM2B) 114055505(RIOX1) 114067858(KDM2A)
FPG: 101912390(KDM2B) 101914594(KDM2A) 101922675(RIOX1)
FCH: 102050781(KDM2B) 102052310(KDM2A) 102052952(RIOX1)
CLV: 102084883(KDM2B) 102085791(RIOX1) 102096388(KDM2A)
EGZ: 104129653(KDM2A) 104130143(KDM2B) 104132280
NNI: 104009386(KDM2A) 104019494(KDM2B) 104020430
ACUN: 113480503(RIOX1) 113486070(KDM2B) 113490447(KDM2A)
PADL: 103912835 103914528(KDM2B) 103925836(KDM2A)
AAM: 106493402(KDM2A) 106495671(KDM2B) 106498095(RIOX1)
ASN: 102376489(RIOX1) 102379559(KDM2B) 102388715(KDM2A)
AMJ: 102560036(RIOX1) 102565389(KDM2A) 106736919(KDM2B)
PSS: 102446014(KDM2B) 102450180(RIOX1) 102452607 102454325 102464032(KDM2A)
CMY: 102933242(RIOX1) 102933550(KDM2B) 102946953(KDM2A)
CPIC: 101941489(KDM2B) 101944320(KDM2A) 101944414(RIOX1)
ACS: 100555582(kdm2a) 100557128(kdm2b) 100557464(riox1)
PVT: 110083885(KDM2B) 110085628(KDM2A) 110088098(RIOX1)
PBI: 103055385(KDM2B) 103064072(RIOX1) 103064363(KDM2A)
PMUR: 107286966(KDM2B) 107290099(RIOX1) 107296660(KDM2A)
PMUA: 114586201(KDM2B) 114594532(RIOX1) 114601850(KDM2A)
GJA: 107109113(KDM2A) 107111814(RIOX1) 107115913
XTR: 100488246(riox1) 448624(kdm2b) 496596(kdm2a)
NPR: 108787819(KDM2B) 108788943(CUNH14orf169) 108801104(KDM2A)
DRE: 100536129 560815(riox1) 571851(kdm2aa) 799441(kdm2ab)
IPU: 108257725(riox1) 108262769 108264901(kdm2b) 108268705(kdm2a)
PHYP: 113532105(riox1) 113539151 113542768(kdm2a)
AMEX: 103024695 103030174 103034250(kdm2b) 103035470(riox1) 103039345(kdm2a)
EEE: 113567668(kdm2b) 113570717(kdm2a) 113571493 113571701(riox1) 113586912
CSEM: 103381232(c7h14orf169) 103384305 103390456 103390943(kdm2a) 103398071(kdm2b)
LCF: 108872906 108873507(cunh14orf169) 108878302(kdm2a) 108878436 108879821
ELS: 105014887 105017561(riox1) 105022887 105024850(kdm2b) 105028557(kdm2a)
LCM: 102352369(RIOX1) 102358334(KDM2A) 102363992(KDM2B)
CMK: 103180532(fbxl19) 103181758(riox1) 103184391(kdm2b)
RTP: 109913950(kdm2b) 109917965 109921777(riox1) 109925258(kdm2a)
CIN: 100179691 778852(zf(cxxc)-1)
DME: Dmel_CG11033(Kdm2) Dmel_CG2982(NO66)
DSE: 6607159
DSI: Dsimw501_GD18594(Dsim_GD18594)
DAN: 6499376
DVI: 6629815
BMAN: 114246951
CEL: CELE_T26A5.5(jhdm-1) CELE_T28F2.4(jmjc-1)
SHX: MS3_06799
EGL: EGR_06616
ATH: AT3G20810(JMJD5)
ALY: 9321472
CRB: 17891861
BRP: 103869271(JMJ30)
BOE: 106344094
RSZ: 108856700
THJ: 104816908
CPAP: 110811807
CIT: 102619679
TCC: 18589751
GRA: 105772548
GAB: 108486474
VRA: 106755596
VAR: 108338976
VUN: 114169300
CCAJ: 109798941
LJA: Lj3g3v3271520.2(Lj3g3v3271520.2)
ADU: 107476784
AIP: 107629002
FVE: 101301573
RCN: 112165779
PPER: 18774862
PMUM: 103341839
PAVI: 110770961
MDM: 103447103
PXB: 103963740
ZJU: 107412622
CSV: 101210592
CMO: 103492075
MCHA: 111021407
CMAX: 111467010
CMOS: 111434618
CPEP: 111792583
RCU: 8274402
JCU: 105650478
MESC: 110618015
POP: 7496047
PEU: 105134948
JRE: 108998746
VVI: 100267241
SLY: 101251119(JMJ524)
SPEN: 107003102
SOT: 102591001
CANN: 107874851
NSY: 104226658
NTO: 104094942
NAU: 109220083
INI: 109152231
SIND: 105163547
OEU: 111380176
HAN: 110927139
LSV: 111890249
CCAV: 112522168
DCR: 108227309
BVG: 104889940
SOE: 110801981
NNU: 104597503
PSOM: 113320488
DOSA: Os08t0508500-00(Os08g0508500) Os09t0489200-00(Os09g0489200)
OBR: 102705376
ATS: 109731690(LOC109731690) 109755349(LOC109755349)
SBI: 8064848
ZMA: 100272621
SITA: 101763987
PDA: 103711389
EGU: 105050222
DCT: 110098668
PEQ: 110029507
ATR: 18439881
MNG: MNEG_6536
SCE: YER051W(JHD1)
ERC: Ecym_4349
KMX: KLMA_40344(JHD1)
TPF: TPHA_0C01220(TPHA0C01220)
TDL: TDEL_0H02210(TDEL0H02210)
CAL: CAALFM_CR00750CA(CaO19.3281)
SLB: AWJ20_3653(JHD1)
ANI: AN7455.2
ANG: ANI_1_3330024(An02g14310)
ABE: ARB_05068
TVE: TRV_06674
PTE: PTT_16007
SPO: SPCC622.16c(epe1)
CNE: CNG00620
CNB: CNBG4160
TASA: A1Q1_07436
LBC: LACBIDRAFT_316140(JMJ16203)
MGL: MGL_3466
DDI: DDB_G0287513(jcdG)
DFA: DFA_11703(jcdG)
SMIN: v1.2.004901.t1(symbB.v1.2.004901.t1)
SPAR: SPRG_19899
TCR: 508141.30
GOH: B932_3351
MIT: OCO_32100
MIA: OCU_31990
MID: MIP_04812
MYO: OEM_31660
MIR: OCQ_33210
MMC: Mmcs_5250
MKM: Mkms_5339
MJL: Mjls_5630
MMM: W7S_16070
MAUU: NCTC10437_00364(yxbC)
MTER: 4434518_00510(yxbC)
RHB: NY08_907
GBR: Gbro_2909
SALB: XNR_5758
SGB: WQO_03070
SFA: Sfla_5934
SALS: SLNWT_3295
STRP: F750_0636
STRD: NI25_36560
AAU: AAur_0378
SERJ: SGUI_1093
NDK: I601_2829
NML: Namu_3066
GOB: Gobs_3279
AOI: AORI_4660
PSEA: WY02_10010
SAQ: Sare_2302
MIL: ML5_5502
ASE: ACPL_3966
ACTN: L083_5136
AFS: AFR_26720
ACTS: ACWT_3837
GLJ: GKIL_1768
 » show all
Reference
1  [PMID:16362057]
  Authors
Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y.
  Title
Histone demethylation by a family of JmjC domain-containing proteins.
  Journal
Nature 439:811-6 (2006)
DOI:10.1038/nature04433
  Sequence
[hsa:22992 84678] [sce:YER051W]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.27
IUBMB Enzyme Nomenclature: 1.14.11.27
ExPASy - ENZYME nomenclature database: 1.14.11.27
BRENDA, the Enzyme Database: 1.14.11.27
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