KEGG   ENZYME: 1.14.11.64Help
Entry
EC 1.14.11.64               Enzyme                                 

Name
glutarate dioxygenase;
csiD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)
Reaction(IUBMB)
glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2 [RN:R12216]
Reaction(KEGG)
Substrate
glutarate [CPD:C00489];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(S)-2-hydroxyglutarate [CPD:C03196];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.
History
EC 1.14.11.64 created 2019
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K15737  glutarate dioxygenase
Genes
ECO: b2659(csiD)
ECJ: JW5427(ygaT)
ECD: ECDH10B_2826(ygaT)
EBW: BWG_2402(csiD)
ECE: Z3956
ECS: ECs3520
ECF: ECH74115_3901
ETW: ECSP_3604(ygaT)
ELX: CDCO157_3281
EOI: ECO111_3383(csiD)
EOJ: ECO26_3728(csiD)
EOH: ECO103_3200(csiD)
ECOO: ECRM13514_3497(csiD)
ECOH: ECRM13516_3363(csiD)
ESL: O3K_06255
ESO: O3O_19390
ESM: O3M_06300
ECK: EC55989_2927(ygaT)
ECG: E2348C_2922(csiD)
EOK: G2583_3305(csiD)
ELH: ETEC_2856
ECP: ECP_2622
ECOS: EC958_2923(ygaT)
ECV: APECO1_3861(ygaT)
ECY: ECSE_2912
ECR: ECIAI1_2755(ygaT)
ECQ: ECED1_3112(ygaT)
EUM: ECUMN_2983(ygaT)
ECT: ECIAI39_2845(ygaT)
EOC: CE10_3077(csiD)
EBR: ECB_02515(csiD)
EBL: ECD_02515(csiD)
EBE: B21_02479(csiD)
EBD: ECBD_1060
ECI: UTI89_C3014(ygaT)
ECZ: ECS88_2923(ygaT)
ECC: c3207(ygaT)
ELO: EC042_2856(csiD)
ESE: ECSF_2456
EKF: KO11_09710(csiD)
EAB: ECABU_c29220(ygaT)
EDJ: ECDH1ME8569_2575(csiD)
ELW: ECW_m2856(csiD)
ELL: WFL_13955(csiD)
ELC: i14_2938(ygaT)
ELD: i02_2938(ygaT)
ELF: LF82_0367(csiD)
ECOI: ECOPMV1_02911(csiD)
ECOJ: P423_14570
EFE: EFER_0413(ygaT)
ESZ: FEM44_03115(csiD)
STY: STY2909
STT: t2684
STM: STM2789
SEY: SL1344_2773(csiD)
SEF: UMN798_3028(csiD)
SENR: STMDT2_26941(csiD)
SEND: DT104_27911(csiD)
SENI: CY43_14580
SPT: SPA2646
SEK: SSPA2467
SEI: SPC_2832
SEC: SCH_2721(ygaT)
SHB: SU5_03274
SENS: Q786_13395
SEG: SG2694
SEL: SPUL_2783
SET: SEN2633
SENA: AU38_13360
SENO: AU37_13370
SENV: AU39_13370
SENQ: AU40_15050
SENL: IY59_13955
SEEP: I137_13260
SENE: IA1_13315
SBG: SBG_2414
SBZ: A464_2810
SALZ: EOS98_05600(csiD)
SFL: SF2686
SFX: S2871
SFV: SFV_2844
SFE: SFxv_2945(csiD)
SFN: SFy_3810
SFS: SFyv_3891
SFT: NCTC1_02953(csiD)
SSN: SSON_2803
SBO: SBO_2860
KPN: KPN_00258(csiD)
KPU: KP1_1104
KPP: A79E_4032
KPE: KPK_4474(csiD)
KPJ: N559_4163
KPNU: LI86_21390
KPNK: BN49_1226(csiD)
KVA: Kvar_4129
EAE: EAE_12085
EAR: CCG31546
CKO: CKO_04006
CPOT: FOB25_16995(csiD)
CAMA: F384_14485
RTG: NCTC13098_05981(csiD_1)
LER: GNG29_02795(csiD)
LEA: GNG26_02395(csiD)
IZH: FEM41_10615(csiD)
EBF: D782_2799
PRE: PCA10_49700(csiD)
PPU: PP_2909(csiD)
PPF: Pput_2782
PPT: PPS_3002
PPI: YSA_10038
PPX: T1E_0473
PPUH: B479_14930
PPUT: L483_12730
PPUN: PP4_29100(csiD)
PPUD: DW66_3269
PMON: X969_14385
PMOT: X970_14030
PKC: PKB_4027(csiD)
CPS: CPS_4661
PIN: Ping_2737
LPH: LPV_0222(csiD)
CSA: Csal_1996
HBE: BEI_0618(csiD)
HVN: EI420_11305(csiD)
OCE: GU3_03510
CNC: CNE_BB1p02240(csiD)
PPNO: DA70_22145
BAV: BAV3238(csiD)
CTES: O987_21475
HYN: F9K07_22130(csiD)
PUB: SAR11_1354(gab)
BTM: MC28_0159
BWW: bwei_4105(csiD)
BMYO: BG05_5008(csiD)
BMYC: DJ92_3470(csiD)
HLI: HLI_15330
ASOC: CB4_03263
SPAE: E2C16_04230(csiD)
PANC: E2636_12560(csiD)
 » show all
Taxonomy
Reference
1  [PMID:30498244]
  Authors
Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS.
  Title
Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
  Journal
Nat Commun 9:5071 (2018)
DOI:10.1038/s41467-018-07563-6
  Sequence
[eco:b2659]
Reference
2  [PMID:29844506]
  Authors
Zhang M, Gao C, Guo X, Guo S, Kang Z, Xiao D, Yan J, Tao F, Zhang W, Dong W, Liu P, Yang C, Ma C, Xu P
  Title
Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
  Journal
Nat Commun 9:2114 (2018)
DOI:10.1038/s41467-018-04513-0
  Sequence
[ppu:PP_2909]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.64
IUBMB Enzyme Nomenclature: 1.14.11.64
ExPASy - ENZYME nomenclature database: 1.14.11.64
BRENDA, the Enzyme Database: 1.14.11.64
LinkDB All DBs

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