KEGG   ENZYME: 1.14.11.67
Entry
EC 1.14.11.67               Enzyme                                 

Name
[histone H3]-trimethyl-L-lysine4 demethylase;
KDM5A (gene name);
KDM5B (gene name);
KDM5C (gene name);
KDM5D (gene name);
JARID1A (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6,N6-trimethyl-L-lysine4,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 = a [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2 (overall reaction) [RN:R12461];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 [RN:R09510];
(1c) a [histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine4 + succinate + formaldehyde + CO2 [RN:R09511]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6,N6-trimethyl-L-lysine4;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4
Product
[histone H3]-L-lysine4;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri-, di-, and mono-methylated forms.
History
EC 1.14.11.67 created 2019
Orthology
K11446  [histone H3]-trimethyl-L-lysine4 demethylase
Genes
HSA: 10765(KDM5B) 5927(KDM5A) 8242(KDM5C) 8284(KDM5D)
PTR: 449032(KDM5D) 451737(KDM5A) 457630(KDM5B) 744380(KDM5C)
PPS: 100969555(KDM5B) 100970129(KDM5C) 100980071(KDM5A)
GGO: 101127412(KDM5C) 101149215(KDM5A) 101153769(KDM5B)
PON: 100172643(KDM5C) 100434572(KDM5A) 100450767(KDM5B)
NLE: 100590577(KDM5C) 100591974(KDM5B) 100593603(KDM5A)
MCC: 100270697(KDM5D) 106992262(KDM5C) 706437(KDM5B) 721599(KDM5A)
MCF: 102118086(KDM5C) 102126562(KDM5B) 102140751(KDM5A)
CSAB: 103218353(KDM5A) 103230303(KDM5B) 103232010(KDM5C) 103246987(KDM5D)
RRO: 104658712(KDM5D) 104663374(KDM5C) 104672250(KDM5A) 104674506(KDM5B)
RBB: 108523797 108523849(KDM5A) 108545038(KDM5B)
CJC: 100399585 100401370(KDM5C) 100405218(KDM5B)
SBQ: 101040986(KDM5C) 101053880(KDM5A) 101054224(KDM5B)
MMU: 20591(Kdm5c) 20592(Kdm5d) 214899(Kdm5a) 75605(Kdm5b)
MCAL: 110286928(Kdm5c) 110295764(Kdm5a) 110304747(Kdm5b)
MPAH: 110313472(Kdm5c) 110316599(Kdm5a) 110322297(Kdm5b)
RNO: 100312983(Kdm5d) 304809(Kdm5b) 312678(Kdm5a) 317432(Kdm5c)
MUN: 110546054(Kdm5a) 110546738(Kdm5b) 110566279(Kdm5c)
CGE: 100757111(Kdm5a) 100758549(Kdm5c) 100761435(Kdm5b)
NGI: 103731840(Kdm5b) 103739366(Kdm5a) 103747323(Kdm5c)
HGL: 101697034(Kdm5a) 101709640(Kdm5c) 101711865(Kdm5b)
CCAN: 109684662 109686312(Kdm5b) 109694623(Kdm5a) 109702638
OCU: 100341721(KDM5C) 100351408(KDM5A) 100356218(KDM5B)
TUP: 102477639(KDM5B) 102483934(KDM5C) 102494185(KDM5A)
CFA: 477727(KDM5A) 479999(KDM5B) 491894(KDM5C)
VVP: 112911956(KDM5C) 112911964 112917407(KDM5A) 112934568(KDM5B)
AML: 100476032(KDM5A) 100483283(KDM5B) 100484551(KDM5C)
UMR: 103657783(KDM5B) 103675225 103675721(KDM5A)
UAH: 113242535(KDM5B) 113247519(KDM5C) 113258031(KDM5A)
ORO: 101370942(KDM5B) 101371710(KDM5C) 101372331(KDM5A) 101375635
FCA: 101087846(KDM5A) 101091600(KDM5C) 101101609(KDM5B)
PTG: 102953605(KDM5B) 102957240(KDM5C) 102962286(KDM5A) 102965571
PPAD: 109256462(KDM5B) 109260277(KDM5C) 109276231(KDM5A)
AJU: 106965399(KDM5A) 106974127(KDM5B) 106985380(KDM5C) 106989091
BTA: 281490(KDM5C) 507962(KDM5A) 540633(KDM5B)
BOM: 102271619(KDM5A) 102276246(KDM5B) 102285874(KDM5C)
BIU: 109555159(KDM5C) 109559764(KDM5A) 109570476(KDM5B)
BBUB: 102393119(KDM5A) 102405105(KDM5C) 102408415(KDM5B)
CHX: 102178381(KDM5B) 102183856(KDM5A) 102185641(KDM5C)
OAS: 101110351(KDM5B) 101115023(KDM5A) 101121317(KDM5C)
SSC: 100037295(KDM5C) 100294704(KDM5A) 102163404(KDM5B) 110257883
CFR: 102504875(KDM5B) 102505415(KDM5C) 102520574(KDM5A) 102523369
CDK: 105096692(KDM5C) 105102938(KDM5A) 105105928(KDM5B)
BACU: 103009652(KDM5D) 103009914(KDM5B) 103010727(KDM5A) 103011953(KDM5C)
LVE: 103072576(KDM5B) 103083652(KDM5A) 103088289(KDM5C)
OOR: 101270071(KDM5A) 101271172(KDM5C) 101288712(KDM5B)
DLE: 111168309(KDM5B) 111170781(KDM5C) 111176614(KDM5A)
PCAD: 102983382(KDM5B) 102988928(KDM5A) 102992593(KDM5C)
ECB: 100034190(KDM5C) 100056935(KDM5A) 100064707(KDM5B)
EPZ: 103543421 103555110(KDM5B)
EAI: 106827754(KDM5C) 106831523(KDM5A) 106836255 106840227(KDM5B)
MYB: 102239080(KDM5B) 102245023(KDM5C) 102255481(KDM5A)
MYD: 102752699(KDM5A) 102762785(KDM5B) 102775396(KDM5C)
MNA: 107536012(KDM5B) 107542357(KDM5C) 107542684 107546447(KDM5A)
HAI: 109380463(KDM5B) 109388945(KDM5A) 109396384(KDM5C)
DRO: 112311208(KDM5A) 112318809(KDM5B) 112322361(KDM5C)
PALE: 102878118(KDM5A) 102882705(KDM5B) 102883012(KDM5C) 102887656
RAY: 107502986(KDM5B) 107503761(KDM5C) 107509747(KDM5A)
MJV: 108384283(KDM5C) 108396319(KDM5B) 108399069(KDM5A)
LAV: 100660048(KDM5C) 100665887(KDM5A) 100675094(KDM5B)
MDO: 100011885(KDM5B) 100020718(KDM5A) 100379644(KDM5C)
SHR: 100921713(KDM5A) 100925521(KDM5B) 116420405
PCW: 110201022 110218651(KDM5A) 110219561(KDM5B)
OAA: 100075501(KDM5C) 100077577(KDM5B) 100080164(KDM5A)
GGA: 418148(KDM5A) 421168(KDM5B)
MGP: 100548982(KDM5B)
CJO: 107315373(KDM5A) 107324646(KDM5B)
NMEL: 110388134(KDM5B) 110398370(KDM5A)
APLA: 101794048(KDM5A) 101802603(KDM5B)
ACYG: 106030948(KDM5A) 106045876(KDM5B)
TGU: 100220128(KDM5B) 100226987(KDM5A)
LSR: 110469157(KDM5B) 110472936(KDM5A)
SCAN: 103820453(KDM5A) 103822358(KDM5B)
GFR: 102036946(KDM5B) 102042789(KDM5A)
FAB: 101810162(KDM5A) 101819778(KDM5B)
PHI: 102102154(KDM5B) 102104485(KDM5A) 102111304(KDM5C)
PMAJ: 107204784(KDM5A) 107214918(KDM5B)
CCAE: 111927901(KDM5A) 111939719(KDM5B)
CCW: 104692233(KDM5A) 104692454(KDM5B)
ETL: 114064760(KDM5B) 114069392(KDM5A)
FPG: 101914016(KDM5B) 101916107(KDM5A) 101921902(KDM5C)
FCH: 102046513(KDM5C) 102048054(KDM5B) 102049474(KDM5A)
CLV: 102091315(KDM5B) 102097139(KDM5A)
EGZ: 104122023(KDM5B) 104129750(KDM5A)
NNI: 104011099(KDM5B) 104020219(KDM5A)
ACUN: 113488968(KDM5B) 113491464(KDM5A)
PADL: 103913826(KDM5B) 103924376(KDM5A)
AAM: 106488690(KDM5A) 106500239(KDM5B)
AMJ: 102562466(KDM5C) 102563181(KDM5B) 106736739(KDM5A)
PSS: 102450369(KDM5A) 102451841
CMY: 102934613(KDM5B) 102937991(KDM5A)
CPIC: 101942004(KDM5B) 101948551(KDM5A) 101952359(KDM5C)
ACS: 100562154(kdm5a) 100562356(kdm5b) 100565551(kdm5c)
PVT: 110073373(KDM5B) 110076663(KDM5A) 110078625(KDM5C)
PBI: 103057421(KDM5C) 103064844(KDM5A) 103067839(KDM5B)
PMUR: 107285905(KDM5A) 107287109(KDM5B) 107289352(KDM5C)
TSR: 106543320(KDM5B) 106544479 106550471(KDM5A)
PMUA: 114587654(KDM5C) 114599455(KDM5B) 114605015(KDM5A)
GJA: 107105528 107107867(KDM5B) 107120238(KDM5A)
XLA: 108699964(kdm5c.S) 108704489(kdm5c.L) 108704575 108708118 108709501(kdm5b.S) 108712258
XTR: 100488170(kdm5b) 100492348(kdm5a) 780176(kdm5c)
NPR: 108787373(KDM5B) 108788900(KDM5C) 108804616(KDM5A)
DRE: 100333310(kdm5a) 327168(kdm5ba) 415256(kdm5bb) 553406(kdm5c)
IPU: 108254769 108265475 108265643(kdm5bb) 108279764(kdm5a)
NCC: 104953602(kdm5b)
PRET: 103459510(kdm5a) 103465305 103467711(kdm5c) 103467750
ALIM: 106513272(kdm5b) 106519344 106521815(kdm5a) 106527724
AOCE: 111572088 111573173(kdm5a) 111579740 111580302(kdm5c)
SLAL: 111651986(kdm5a) 111654193(kdm5c) 111661918 111667789
HCQ: 109512943(kdm5c) 109522375(kdm5b) 109530074(kdm5a)
BPEC: 110164505 110164696(kdm5c) 110164872(kdm5a) 110171262
MALB: 109956240 109960867(kdm5a) 109966708(kdm5c) 109970307
PKI: 111833285(kdm5a) 111839833(kdm5b) 111847775
LCM: 102354446 102357112(KDM5A) 102367371(KDM5B)
CMK: 103181874(kdm5a) 103190333(kdm5b)
CIN: 778759
SPU: 578457
APLC: 110974950
SKO: 100376922
DME: Dmel_CG9088(lid)
DER: 6540673
DSE: 6613558
DSI: Dsimw501_GD22616(Dsim_GD22616)
DAN: 6497117
DSR: 110185577
DPE: 6589743
DMN: 108162737
DWI: 6642661
DAZ: 108610621
DNV: 108649376
DHE: 111602297
DVI: 6628917
MDE: 101900476
LCQ: 111679656
AAG: 5574390
AME: 410874
BIM: 100744731
BTER: 100648929
CCAL: 108623075
OBB: 114883217
SOC: 105204666
MPHA: 105837910
AEC: 105145222
ACEP: 105617083
PBAR: 105423324
VEM: 105565846
HST: 105181157
DQU: 106746492
CFO: 105258084
LHU: 105671686
PGC: 109852955
OBO: 105285592
PCF: 106787082
NVI: 100120294
CSOL: 105359430
MDL: 103569442
TCA: 103314648
DPA: 109540983
ATD: 109598089
NVL: 108567195
HAW: 110371606
API: 100163705
DNX: 107174064
AGS: 114123745
RMD: 113550660
BTAB: 109034748
CLEC: 106666620
ZNE: 110834947
FCD: 110861779
PVM: 113822739
TUT: 107371409
DPTE: 113795667
CSCU: 111633283
PTEP: 107441111
CEL: CELE_ZK593.4(rbr-2)
CBR: CBG05959(Cbr-rbr-2)
BMY: Bm1_31510
PCAN: 112571484
CRG: 105342266
OBI: 106868491
LAK: 106176719
SHX: MS3_04542
EPA: 110247338
ADF: 107340938
AMIL: 114969044
PDAM: 113683111
SPIS: 111339408
DGT: 114521659
HMG: 100214586(kdm5a)
AQU: 100639023
ATH: AT1G63490
ALY: 9324019
CRB: 17894403
BRP: 103838273
BOE: 106318075
RSZ: 108827565
THJ: 104818027
CIT: 102617380
TCC: 18606515
GRA: 105792217
GHI: 107936696
GAB: 108469525
DZI: 111277986
EGR: 104441751
GMX: 100789512
GSJ: 114376769
VRA: 106777566
VAR: 108335641
VUN: 114174716
CCAJ: 109801296
CAM: 101496163
LJA: Lj2g3v2017660.2(Lj2g3v2017660.2)
ADU: 107488264
AIP: 107643076
LANG: 109331235
FVE: 101303512
RCN: 112180802
PPER: 18776513
PMUM: 103337463
PAVI: 110758014
MDM: 103454748
PXB: 103954804
ZJU: 107429894
CSV: 101216734
CMO: 103482743
MCHA: 111026169
CMAX: 111468889
CMOS: 111435652
CPEP: 111808172
JCU: 105645808
HBR: 110672143
MESC: 110627589
POP: 18097038
PEU: 105124388
JRE: 108984403
VVI: 100261599
SLY: 101259658
SPEN: 107028578
SOT: 102601233
CANN: 107865060
NSY: 104218212
NTO: 104110228
NAU: 109242262
INI: 109153058
SIND: 105157801
OEU: 111375128
HAN: 110922607
LSV: 111920830
CCAV: 112528803
DCR: 108208906
BVG: 104907854
SOE: 110778623
NNU: 104596082
OSA: 9271593
DOSA: Os06t0731600-00(Os06g0731600)
OBR: 102708534
BDI: 100829070
ATS: 109777849(LOC109777849)
SBI: 8066399
ZMA: 103626493
SITA: 101767595
PDA: 103705556
EGU: 105054844
MUS: 103998506
DCT: 110102954
PEQ: 110018573
AOF: 109847387
ATR: 18423039
SCE: YJR119C(JHD2)
ERC: Ecym_7196
KMX: KLMA_60433(JHD2)
NCS: NCAS_0H00320(NCAS0H00320)
NDI: NDAI_0D00270(NDAI0D00270)
TPF: TPHA_0E00310(TPHA0E00310)
TBL: TBLA_0J00310(TBLA0J00310)
TDL: TDEL_0H00660(TDEL0H00660)
KAF: KAFR_0A03230(KAFR0A03230)
PIC: PICST_88926(RBP2)
CAL: CAALFM_C400260WA(CaO19.5651)
NCR: NCU01238
NTE: NEUTE1DRAFT127630(NEUTE1DRAFT_127630)
MGR: MGG_04878
SSCK: SPSK_08278
NHE: NECHADRAFT_49243(JMJ2102)
MAW: MAC_04053
MAJ: MAA_01434
CMT: CCM_07966
BFU: BCIN_02g00190(Bcecm5)
MBE: MBM_08533
ANI: AN8211.2
ANG: ANI_1_734084(An09g05800)
ABE: ARB_06850
TVE: TRV_05239
PTE: PTT_07707
CNE: CND05870
CNB: CNBD0520
TASA: A1Q1_03515
LBC: LACBIDRAFT_311495(JMJ16202)
ABP: AGABI1DRAFT119979(AGABI1DRAFT_119979)
ABV: AGABI2DRAFT188580(AGABI2DRAFT_188580)
MGL: MGL_2159
MRT: MRET_0349
SPAR: SPRG_10504
 » show all
Reference
1  [PMID:17310255]
  Authors
Seward DJ, Cubberley G, Kim S, Schonewald M, Zhang L, Tripet B, Bentley DL
  Title
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins.
  Journal
Nat Struct Mol Biol 14:240-2 (2007)
DOI:10.1038/nsmb1200
  Sequence
[sce:YJR119C] [mmu:75605]
Reference
2  [PMID:17320163]
  Authors
Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr
  Title
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
  Journal
Cell 128:889-900 (2007)
DOI:10.1016/j.cell.2007.02.013
  Sequence
[hsa:5927] [mmu:214899]
Reference
3  [PMID:17320160]
  Authors
Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y
  Title
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3  lysine 4 demethylases.
  Journal
Cell 128:1077-88 (2007)
DOI:10.1016/j.cell.2007.02.017
  Sequence
[hsa:8242]
Reference
4  [PMID:17320161]
  Authors
Christensen J, Agger K, Cloos PA, Pasini D, Rose S, Sennels L, Rappsilber J, Hansen KH, Salcini AE, Helin K
  Title
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
  Journal
Cell 128:1063-76 (2007)
DOI:10.1016/j.cell.2007.02.003
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.67
IUBMB Enzyme Nomenclature: 1.14.11.67
ExPASy - ENZYME nomenclature database: 1.14.11.67
BRENDA, the Enzyme Database: 1.14.11.67
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