Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy

6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)

6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 [RN:R08764]

R08764
Reaction

6-hydroxynicotinate [CPD:C01020];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.

EC 1.14.13.114 created 2010

1  [PMID:10091591]

Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T

Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.

Eur J Biochem 260:120-6 (1999)
DOI:10.1046/j.1432-1327.1999.00124.x

2  [PMID:18678916]

Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E

Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.

Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105

[ppu:PP_3944]