| Entry |
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| Name |
3-(3-hydroxyphenyl)propanoate hydroxylase;
mhpA (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating)
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| Reaction(IUBMB) |
(1) 3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+ [RN: R06786];
(2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+ [RN: R06787]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
3-(2,3-dihydroxyphenyl)propanoate [CPD: C04044];
H2O [CPD: C00001];
NAD+ [CPD: C00003];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD: C12623]
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| Comment |
A flavoprotein (FAD). This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.
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| History |
EC 1.14.13.127 created 2011
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K05712 | 3-(3-hydroxy-phenyl)propionate hydroxylase |
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| Genes |
» show all
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| Reference |
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| Authors |
Burlingame R, Chapman PJ. |
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| Title |
Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Burlingame RP, Wyman L, Chapman PJ |
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| Title |
Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. |
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| Journal |
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| Reference |
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| Authors |
Ferrandez A, Garcia JL, Diaz E. |
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| Title |
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Diaz E, Ferrandez A, Garcia JL. |
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| Title |
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. |
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| Journal |
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| Sequence |
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| Other DBs |
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| LinkDB |
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