Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy

taxusin,NADPH:oxygen 7-oxidoreductase

taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O [RN:R09868]

R09868
Reaction

taxusin [CPD:C20152];
O2 [CPD:C00007];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Requires cytochrome P-450. From the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis.

EC 1.14.13.147 created 2012

1  [PMID:15157877]

Chau M, Jennewein S, Walker K, Croteau R

Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 beta-hydroxylase.

Chem Biol 11:663-72 (2004)
DOI:10.1016/j.chembiol.2004.02.025

[ag:AAQ75553]