Entry |
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Name |
phenylacetyl-CoA 1,2-epoxidase;
ring 1,2-phenylacetyl-CoA epoxidase;
phenylacetyl-CoA monooxygenase;
PaaAC;
PaaABC(D)E
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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Sysname |
phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing)
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Reaction(IUBMB) |
phenylacetyl-CoA + NADPH + H+ + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O [RN: R09838]
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Reaction(KEGG) |
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Substrate |
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Product |
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA [CPD: C20062];
NADP+ [CPD: C00006];
H2O [CPD: C00001]
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Comment |
Part of the aerobic pathway of phenylacetate catabolism in Escherichia coli and Pseudomonas putida.
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History |
EC 1.14.13.149 created 2012
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Pathway |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K02609 | ring-1,2-phenylacetyl-CoA epoxidase subunit PaaA |
K02611 | ring-1,2-phenylacetyl-CoA epoxidase subunit PaaC |
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Genes |
» show all
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Reference |
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Authors |
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G |
Title |
Bacterial phenylalanine and phenylacetate catabolic pathway revealed. |
Journal |
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Sequence |
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Reference |
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Authors |
Grishin AM, Ajamian E, Zhang L, Cygler M |
Title |
Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex. |
Journal |
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Sequence |
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Reference |
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Authors |
Grishin AM, Ajamian E, Tao L, Zhang L, Menard R, Cygler M. |
Title |
Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. |
Journal |
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Sequence |
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Other DBs |
UM-BBD (Biocatalysis/Biodegradation Database): | 1.14.13.149 |
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LinkDB |
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