| Entry |
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| Name |
6-hydroxy-3-succinoylpyridine 3-monooxygenase;
6-hydroxy-3-succinoylpyridine hydroxylase;
hspA (gene name);
hspB (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)
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| Reaction(IUBMB) |
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O [RN: R09472]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2].
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| History |
EC 1.14.13.163 created 2012
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| Pathway |
| ec00760 | Nicotinate and nicotinamide metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K15359 | 6-hydroxy-3-succinoylpyridine 3-monooxygenase |
| K18276 | 6-hydroxy-3-succinoylpyridine 3-monooxygenase |
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| Genes |
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| Reference |
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| Authors |
Tang H, Wang S, Ma L, Meng X, Deng Z, Zhang D, Ma C, Xu P |
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| Title |
A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Tang H, Yao Y, Zhang D, Meng X, Wang L, Yu H, Ma L, Xu P |
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| Title |
A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida. |
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| Journal |
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| Sequence |
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| Other DBs |
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| LinkDB |
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