| Entry |
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| Name |
pentalenolactone D synthase;
penE (gene name);
pntE (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D forming)
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| Reaction(IUBMB) |
1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = pentalenolactone D + NADP+ + H2O [RN: R10154]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A FAD-dependent oxygenase. Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. The ketone undergoes a biological Baeyer-Villiger reaction. Part of the pathway of pentalenolactone biosynthesis.
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| History |
EC 1.14.13.170 created 2012
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| Pathway |
| ec00999 | Biosynthesis of various secondary metabolites - part 1 |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K18091 | pentalenolactone D synthase |
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| Genes |
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| Reference |
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| Authors |
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE |
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| Title |
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone. |
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| Journal |
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| Sequence |
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| Other DBs |
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| LinkDB |
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