Entry |
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Name |
aklavinone 12-hydroxylase;
DnrF;
RdmE;
aklavinone 11-hydroxylase (incorrect)
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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Sysname |
aklavinone,NADPH:oxygen oxidoreductase (12-hydroxylating)
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Reaction(IUBMB) |
aklavinone + NADPH + H+ + O2 = epsilon-rhodomycinone + NADP+ + H2O [RN: R06683]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase.
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History |
EC 1.14.13.180 created 2013
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Pathway |
ec01057 | Biosynthesis of type II polyketide products |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K15950 | aklavinone 12-hydroxylase |
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Reference |
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Authors |
Filippini S, Solinas MM, Breme U, Schluter MB, Gabellini D, Biamonti G, Colombo AL, Garofano L |
Title |
Streptomyces peucetius daunorubicin biosynthesis gene, dnrF: sequence and heterologous expression. |
Journal |
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Sequence |
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Reference |
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Authors |
Niemi J, Wang Y, Airas K, Ylihonko K, Hakala J, Mantsala P |
Title |
Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens. |
Journal |
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Sequence |
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Other DBs |
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LinkDB |
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